Good and poor mobilizing patients differ in mobilized CD34+ cell adhesion molecule profiles

Ford, Clyde D.; Greenwood, Jay H.; Anderson, Jeffrey J.; Handrahan, Diana; Petersen, Finn

doi:10.1111/j.0041-1132.2004.04035.x

Cited by 10 publications

(11 citation statements)

References 13 publications

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“…Previous studies have shown that KG1a, PB and MB express CD11a, CD18, CD29, CD49d and CD49e [32,36], in agreement with our data and lower levels of CD11a are associated with mobilization from bone marrow without modulating subsequent engraftment [39]. In our study, CD11a expression on MB was between the levels expressed on KG1a and PB populations (37%, 25% and 50% respectively) but lower than mentioned in previous studies [39].…”

Section: Discussionsupporting

confidence: 92%

“…In our study, CD11a expression on MB was between the levels expressed on KG1a and PB populations (37%, 25% and 50% respectively) but lower than mentioned in previous studies [39]. The reason for this difference is not clear but increasing the concentration of stem cell factor (SCF) in culture increases expression of CD11a, VLA-4 and CD44 on cord blood CD34 + cells [40] and the absence of SCF from our media may explain the lower levels we found [1,19,21,41].…”

Section: Discussioncontrasting

confidence: 76%

See 1 more Smart Citation

Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4

Crosby¹,

Ross²,

Newsome³

et al. 2009

Journal of Hepatology

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 76%

Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4

Crosby¹,

Ross²,

Newsome³

et al. 2009

Journal of Hepatology

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“…[14,[27][28][29][30][31][32][33][34][35][36][37][38] Such contributions, as well as differential contributions to the homing of grafted MPB or ssBM CFU-C could be definitively tested by studying genetic mouse models. Marrow homing of genetically deficient cells (MMP9-/-, β2-/-, L-selectin) or in genetically deficient hosts (E-selectin-/-), whether from MPB or from ssBM, was equally efficient as that of WT cells (Fig.…”

Section: Favorable Homing Of Mpb Persists In the Absence Of Mmp9 β2-mentioning

confidence: 99%

Hematopoietic Progenitor Cells (HPC) from Mobilized Peripheral Blood Display Enhanced Migration and Marrow Homing Compared to Steady-State Bone Marrow HPC

Bönig

Priestley

Oehler

et al. 2007

Experimental Hematology

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Objective-Faster engraftment of G-CSF mobilized peripheral blood (MPB) transplants compared to steady-state bone marrow (ssBM) is well documented and clinically relevant. A number of different factors likely contribute to this outcome. In the present study we explored whether independent of cell number there are intrinsic differences in the efficiency of progenitor cell homing to marrow between MPB and ssBM. Methods-Mobilization was achieved by continuous infusion of G-CSF alone or in combination with other mobilizing agents.In vivo homing assays, in vitro migration assays, gene expression analysis and flow cytometry were utilized to compare homing-related in vivo and in vitro properties of MPB and ssBM HPC.Results-Marrow homing of murine MPB HPC, generated by different mobilizing schemes, was reproducibly significantly superior to that of ssBM, in lethally irradiated as well as in non-irradiated hosts. This phenotype was independent of MMP9, selectins, β2-and α4-integrins. Superior homing was also observed for human MPB HPC transplanted into NOD/SCIDβ2microglobulin-/-recipients. Inhibition of HPC migration abrogated the homing advantage of MPB but did not affect homing of ssBM HPC, whereas enhancement of motility by CD26 inhibition improved marrow homing only of ssBM HPC. Enhanced SDF-1 dependent chemotaxis and low CD26 expression on MPB HPC were identified as potential contributing factors. Significant contributions of the putative alternative SDF-1 receptor, RDC1, were unlikely based on gene expression data. Conclusion-The data suggest increased motility as a converging end point of complex changes seen in MPB HPC which is likely responsible for their favorable homing.

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“…The patients were treated with chemotherapy with (14 patients) or without (43 patients) radiotherapy. The median number of the chemotherapy cycles is 9 (range [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and the median of the number of the chemotherapy regimens is 2 (range 1-5). The number of the patients who were treated with rituximab was 27.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, identification of risk factors for poor mobilization is important for optimal resource utilization. (8)(9)(10)(11)(12)(13). Ozkurt et al showed that poor mobilization frequency was higher in lymphoma patients (14).…”

Section: Introductionmentioning

confidence: 99%

Lenfoma hastalarında yetersiz hematopoiteik kök hücre mobilizasyonu için risk faktörleri

Tombuloğlu¹,

Dönmez²

2017

Ege Tıp Dergisi

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Aim: Poor mobilization is an important problem in autologous stem cell transplantation. The ratio of poor mobilization is higher in lymphoma patients. There is limited data about poor mobilization in lymphoma patients. We aimed to identify the possible risk factors for poor mobilization using data from 57 lymphoma patients. Materials and Methods:We retrospectively reviewed the data of 57 lymphoma patients (40 with non-Hodgkin lymphoma and 17 with Hodgkin lymphoma) who have been mobilized during 1998 -2011. Patient data were recruited from the archives of the hematology clinic. Results:We documented poor mobilization in 13 (22.8%) patients. Bone marrow involvement (odds ratio [OR] =15.52, p=0.002) and being treated with more than ten cycles of chemotherapies (OR=6.25, p=0.04) were found to be possible risk factors. Conclusion:Leukapheresis staff should be aware of the increased risk of poor mobilization in these cases and remobilization strategies should be considered from the beginning in these patients with risk factors for more effective resource utilization.Keywords: Hematopoietic stem cell mobilization, lymphoma, poor mobilization, risk factors. Öz

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Good and poor mobilizing patients differ in mobilized CD34+ cell adhesion molecule profiles

Abstract: CD11a (LFA-1) expression inversely correlates with mobilization efficiency. Elucidation of the mechanism(s) underlying these observations will require further study.

Cited by 10 publications

References 13 publications

Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4

Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4

Hematopoietic Progenitor Cells (HPC) from Mobilized Peripheral Blood Display Enhanced Migration and Marrow Homing Compared to Steady-State Bone Marrow HPC

Lenfoma hastalarında yetersiz hematopoiteik kök hücre mobilizasyonu için risk faktörleri

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