Good adhesion properties of probiotics: a potential risk for bacteremia?

Abstract

The ability to adhere to human intestinal mucus was tested for lactic acid bacteria of clinical blood culture, human fecal and dairy origin. The blood culture isolates were found to adhere better than the dairy strains. Of the Lactobacillus rhamnosus strains (nine clinical, 10 fecal and three dairy), blood culture isolates adhered better than the fecal strains. Although these results indicate a trend for blood culture isolates to bind to intestinal mucus in higher numbers than strains of dairy and human fecal origin, other factors are also likely to be involved in the etiology of lactobacillemia since some of the clinical Lactobacillus isolates exhibited a relatively low level of adhesion.

Comparative genome analysis reveals key genetic factors associated with probiotic property in Enterococcus faecium strains

“…The ability to adhere to the GIT is reflected to be one of the main selection criteria for potential probiotics as it extends their persistence in the intestine [52] and thus allows the bacterium to exert its probiotic effects for an extended time. However, adhesion is also considered a potential virulence factor for pathogenic bacteria [53]. The intestinal mucus is an important site for bacterial adhesion and colonization [54], and thus adherence property is beneficial to humans in case of probiotics, and it possesses adverse effects in pathogenic strains.…”

Pro- and Synbiotics to Control Inflammation and Infection in Patients With Multiple Injuries

“…Primary bacteremia signifies the lack of availability of any documented source of primary infection. 34 Administration was safe as it was not connected with any episode of infection by any of the species contained in the ingested formula. In experimental studies in rats subjected to intraperitoneal challenge by zymozan or by installation of pneumoperitoneum as well as in clinical studies of our group aiming at the occurrence of bacterial translocation after major intrabdominal surgery, these types of bacteria were isolated from cultures of mesenterial lymph nodes.…”

Diet, Microbiome, and the Intestinal Epithelium: An Essential Triumvirate?

“…Although probiotics have a relatively safe track record in humans, some studies have raised concerns about introducing billions of bacteria into a host [88, 89]. In an effort to circumvent this potential health hazard, attention has been directed on identifying probiotic-derived beneficial molecules that can be used in lieu of whole, live microorganisms.…”