Gonadotropins up-regulate the expression of enolase 2, but not enolase 1, in the rat ovary

Yoshioka, Nozomu; Takahashi, Noriyuki; Tarumi, Wataru; Itoh, Masanori; Ishizuka, Bunpei

doi:10.1507/endocrj.ej11-0098

Cited by 6 publications

(5 citation statements)

References 28 publications

(35 reference statements)

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“…Enolase activity is modulated by oxygen availability and by plasminogen, it is a debated candidate for ischemia outcome prediction and it is known for its role in supporting anaerobic metabolism in tumor cells (Brea et al 2009;Kaca-Orynska et al 2010;Capello et al 2011). Decreased enolase expression was observed only in the ischemic brain of male mice, while no change in enolase levels were observed in any of the female groups, suggesting a possible modulation of enolase expression by hormone-related signaling as already observed in rat ovary (Yoshioka et al 2011). In the direct comparison between STAT3 KO and WT mice, enolase was increased in both sides of male STAT3 KO ischemic brain, reminiscent of the behavior observed in the progression of Alzheimer's disease and mild cognitive impairment in which alpha enolase was found to be consistently up-regulated and oxidatively modified (Butterfield and Lange 2009).…”

Section: Mitochondrial Energy-related Proteins (Table 2)mentioning

confidence: 49%

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Sex differences in brain proteomes of neuron‐specific STAT3‐null mice after cerebral ischemia/reperfusion

Domenico

Casalena

Jia

et al. 2012

Journal of Neurochemistry

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Signal transduction and activator of transcription-3 (STAT3) plays an important role in neuronal survival, regeneration and repair after brain injury. We previously demonstrated that STAT3 is activated in brain after cerebral ischemia specifically in neurons. The effect was sex-specific and modulated by sex steroids, with higher activation in females than males. In the current study, we used a proteomics approach to identify downstream proteins affected by ischemia in male and female wild-type (WT) and neuron-specific STAT3 knockout (KO) mice. We established 4 comparison groups based on the transgenic condition and the hemisphere analyzed, respectively. Moreover, the sexual variable was taken into account and male and female animals were analyzed independently. Results support a role for STAT3 in metabolic, synaptic, structural and transcriptional responses to cerebral ischemia, indeed the adaptive response to ischemia/reperfusion injury is delayed in neuronal-specific STAT3 KO mice. The differences observed between males and females emphasize the importance of sex-specific neuronal survival and repair mechanisms, especially those involving antioxidant and energy-related activities, often caused by sex hormones.

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Section: Mitochondrial Energy-related Proteins (Table 2)mentioning

confidence: 49%

“…2011). Decreased enolase expression was observed only in the ischemic brain of male mice, while no change in enolase levels were observed in any of the female groups, suggesting a possible modulation of enolase expression by hormone‐related signaling as already observed in rat ovary (Yoshioka et al. 2011).…”

Section: Discussionmentioning

confidence: 60%

Sex differences in brain proteomes of neuron‐specific STAT3‐null mice after cerebral ischemia/reperfusion

Domenico

Casalena

Jia

et al. 2012

Journal of Neurochemistry

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“…In vertebrates, ENO has three subunits, α, β and γ, and the homodimer ENO2, which is composed of γ subunits, exists in neurons and neuroendocrine tissues. LH and FSH upregulated ENO2 expression in oocytes and theca cells, activating glycolysis in these cells [ 21 ], suggesting that LH and FSH may be involved in changes of ENO2 mRNA expression during the estrous cycle, and activate the ovarian function by stimulating the glycolysis in oocytes and theca cells. Meanwhile, an increased E 2 level has a negative feedback effect on the FSH level [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Candidate Genes for Twinning Births in Dezhou Donkeys by Detecting Signatures of Selection in Genomic Data

Xie

Zhang

Shen

et al. 2022

Genes

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Twinning trait in donkeys is an important manifestation of high fecundity, but few reports are available elucidating its genetic mechanism. To explore the genetic mechanism underlying the twin colt trait in Dezhou donkeys, DNA from 21 female Dezhou donkeys that had birthed single or twin colts were collected for whole-genome resequencing. FST, θπ and Tajima’s D were used to detect the selective sweeps between single and twin colt fecundity in the Dezhou donkey groups. Another set of 20 female Dezhou donkeys with single or multiple follicles during estrus were selected to compare concentrations of reproductive hormone including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and progesterone (P4). Four candidate genes including ENO2, PTPN11, SOD2 and CD44 were identified in the present study. The CD44 gene had the highest FST value, and ENO2, PTPN11 and SOD2 were screened by two joint analyses (FST and θπ, θπ and Tajima’s D). There was no significant difference in the LH, FSH and P4 levels between the two groups (p > 0.05); however, the serum E2 content in the multi-follicle group was significantly higher than that in the single-follicle group (p < 0.05). The identified candidate genes may provide new insights into the genetic mechanism of donkey prolificacy and may be useful targets for further research on high reproductive efficiency.

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“…These genes are involved in cell metabolism, especially glucose. In the ovary, studies have shown that ENO2 expression is higher during preantral and antral follicle development and lower after ovulation, being controlled by gonadotropins (Yoshioka, Takahashi, Tarumi, Itoh, & Ishizuka, 2011).…”

Section: Discussionmentioning

confidence: 99%

Follicle populations and gene expression profiles of Nelore and Angus heifers with low and high ovarian follicle counts

Favoreto

Loureiro

Ereno

et al. 2018

Molecular Reproduction Devel

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The number of antral follicles counted (AFC) by ultrasound is associated with fertility in cattle. Cows with higher follicle count (HFC) have higher performance in reproductive‐assisted technologies than cows with lower follicle count (LFC). In this study, we aimed to define the preantral follicle count by histology and to identify differentially expressed genes (DEGs) using a microarray in Nelore and Angus heifers with HFC and LFC. The ovaries of each animal were scanned with an ultrasound device 12 to 24 hr after estrus. The groups were formed based on the average number of total follicles (≥3 mm) counted in each breed consistently ± the standard deviation. For the histological analysis, preantral follicles were counted and classified under a stereo microscope, and follicle density was determined. Microarray analysis was performed on pools of three follicles dissected from the ovaries of 15 Nelore (6 HFC and 9 LFC) and 17 Angus heifers (9 HFC and 8 LFC). Angus heifers have increased total and primordial follicle density. Nelore heifers have increased antral follicle count. Different patterns of gene expression regulate follicle recruitment and development in Angus and Nelore heifers and may be associated with the different follicle densities observed in Angus versus Nelore heifers. Furthermore, HFC heifers presented increased expression of genes associated with cellular development and metabolism.

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Gonadotropins up-regulate the expression of enolase 2, but not enolase 1, in the rat ovary

Cited by 6 publications

References 28 publications

Sex differences in brain proteomes of neuron‐specific STAT3‐null mice after cerebral ischemia/reperfusion

Sex differences in brain proteomes of neuron‐specific STAT3‐null mice after cerebral ischemia/reperfusion

Identification of Candidate Genes for Twinning Births in Dezhou Donkeys by Detecting Signatures of Selection in Genomic Data

Follicle populations and gene expression profiles of Nelore and Angus heifers with low and high ovarian follicle counts

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