Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway

Feng, Dingqing; Zhao, Tingting; Yan, Keqin; Liang, Huaping; Liang, Jing; Ying, Zhe; Zhang, Weidong; Ling, Bin

doi:10.3892/or.2017.5784

Cited by 16 publications

(17 citation statements)

References 37 publications

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“…To address this issue, we focused our research on the effect of PtGs and studied, in addition to FSH, the effects of luteinizing hormone (LH) and prolactin (PRL) on colorectal cancer (CRC) cell lines. All of these PtGs are potent mitogens, and their role has already been associated with other human malignancies, including prostate [ 14 ], breast [ 15 ], lung [ 16 ], and ovarian cancer [ 17 ] as well as certain sarcomas [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer

et al. 2018

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BackgroundColorectal cancer (CRC) is a leading cause of death in the western world, and its incidence increases with patient age. It is also known that with age there occur changes in the levels of certain hormones, including an increase in the secretion of pituitary gonadotropins (PtGs) as a result of the loss of gonadal hormone feedback. We recently reported that functional PtG receptors are expressed in human lung cancer cells, rhabdomyosarcoma cells, and malignant hematopoietic stem cells.FindingsHere we report for the first time that the receptors for follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are expressed in primary tumor samples isolated from CRC patients as well as in the established human CRC cell lines HTC116 and HTB37. Moreover, we also report that PtGs stimulate chemotaxis, adhesion, and proliferation of these cell lines.ConclusionsOur results suggest that PtGs play an important and underappreciated role in CRC pathogenesis, and we call for further studies to better define their role in gastrointestinal malignancies and their direct effect on putative CRC cancer stem cells.

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Section: Introductionmentioning

confidence: 99%

A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer

et al. 2018

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“…COX-2 can also promote the metastasis and invasion of ovarian cancer through induction of matrix metalloproteinases (MMPs) in extracellular matrix and the decomposition of collagen matrix which may be involved in activation of the PI3K/AKT signaling pathway (83). Inhibition of COX-2 with its specific inhibitor NS-398 can increase the expression of E-cadherin and inhibit the expression of slug, vimentin, MMP2, and MMP9, thereby to suppress invasion and metastasis of ovarian cancer cells under estrogen treatment (84). Moreover, overexpression of COX-2 in ovarian cancer cells can directly up-regulate Bcl-2 expression through the increased synthesis of PGs.…”

Section: Cyclooxygenase-2 (Cox-2)mentioning

confidence: 99%

Deregulation of Lipid Metabolism: The Critical Factors in Ovarian Cancer

Shen²,

et al. 2020

Front. Oncol.

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Ovarian cancer is one of the most malignant gynecological cancers around the world. In spite of multiple treatment options, the five-year survival rate is still very low. Several metabolism alterations are described as a hallmark in cancers, but alterations of lipid metabolism in ovarian cancer have been paid less attention. To explore new markers/targets for accurate diagnosis, prognosis, and therapeutic treatments based on metabolic enzyme inhibitors, here, we reviewed available literature and summarized several key metabolic enzymes in lipid metabolism of ovarian cancer. In this review, the rate limiting enzymes associated with fatty acid synthesis (FASN, ACC, ACLY, SCD), the lipid degradation related enzymes (MAGL, CPT, 5-LO, COX2), and the receptors related to lipid uptake (FABP4, CD36, LDLR), which promote the development of ovarian cancer, were analyzed and evaluated. We also focused on the review of application of current metabolic enzyme inhibitors for the treatment of ovarian cancer through which the potential therapeutic agents may be developed for ovarian cancer therapy.

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“…In addition, induction of PIWIL2 was also reported to endow cancer stem cell-like properties to human fibroblasts with ectopic expression of these stemness markers [90]. While there are many papers on FSH causing OC proliferation and migration [4,[92][93][94][95], there is a study claiming FSH as having protective properties against cancer [96]. Therefore, further investigation is needed to identify the relationship between FSH and PIWIL2 and whether they contribute to or against the development of HGSOC.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Molecular and Clinical Analysis of the piRNA Pathway Genes in Ovarian Cancer

Lee

Lokman

Oehler

et al. 2020

Cancers

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Ovarian cancer (OC) is one of the most lethal gynecological malignancies, yet molecular mechanisms underlying its origin and progression remain poorly understood. With increasing reports of piRNA pathway deregulation in various cancers, we aimed to better understand its role in OC through a comprehensive analysis of key genes: PIWIL1-4, DDX4, HENMT1, MAEL, PLD6, TDRD1,9 and mutants of PIWIL1 (P1∆17) and PIWIL2 (PL2L60). High-throughput qRT-PCR (n = 45) and CSIOVDB (n = 3431) showed differential gene expression when comparing benign ovarian tumors, low grade OC and high grade serous OC (HGSOC). Significant correlation of disparate piRNA pathway gene expression levels with better progression free, post-progression free and overall survival suggests a complex role of this pathway in OC. We discovered PIWIL3 expression in chemosensitive but not chemoresistant primary HGSOC cells, providing a potential target against chemoresistant disease. As a first, we revealed that follicle stimulating hormone increased PIWIL2 expression in OV-90 cells. PIWIL1, P1∆17, PIWIL2, PL2L60 and MAEL overexpression in vitro and in vivo decreased motility and invasion of OVCAR-3 and OV-90 cells. Interestingly, P1∆17 and PL2L60, induced increased motility and invasion compared to PIWIL1 and PIWIL2. Our results in HGSOC highlight the intricate role piRNA pathway genes play in the development of malignant neoplasms.

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Gonadotropins promote human ovarian cancer cell migration and invasion via a cyclooxygenase 2-dependent pathway

Cited by 16 publications

References 37 publications

A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer

A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer

Deregulation of Lipid Metabolism: The Critical Factors in Ovarian Cancer

A Comprehensive Molecular and Clinical Analysis of the piRNA Pathway Genes in Ovarian Cancer

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