Gonadotropins of the Pituitary of Postmenopausal Women

Bahn, Robert C.; Lorenz, Nona; Bennett, Warren A.; Albert, A.

doi:10.1210/endo-53-4-455

Cited by 15 publications

(2 citation statements)

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“…This is consistent with the metabolic clearance rate studies (1, 2) which indicate a more than 10-fold increase in the daily production rate for FSH but only 3-to 4-fold increase for LH between pre-and postmenopausal women. Limited evidence available on pituitary gonadotropin content indicates that an approximate 3-fold increase in FSH with a relatively unchanged LH content is found in post-as compared to premenopausal women (16). By inference, the increased release of FSH and LH after ovariectomy is associated with an increased net synthesis which is more pronounced for FSH than for LH.…”

Section: Resultsmentioning

confidence: 94%

The effect of ovariectomy on gonadotropin release

Yen¹,

Tsai²

1971

J. Clin. Invest.

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ABST R A CT The sequential changes in the concentration and pattern of circulating luteinizing hormone (LH) and follicle-stimulating hormone (FSH)1 following bilateral ovariectomy were determined in 10 premenopausal women. The initial (1st wk) and delayed (3 wk) secretory responses of serum LH and FSH as related to the phases of the menstrual cycle were examined. Ovariectomy during follicular phase was accompanied by a prompt and much greater rise in both LH and FSH during the 1st wk. This rapid rise was followed by a transient decline between the 7th and 10th day which resulted in a biphasic pattern. In contrast, a slower and progressive rise in serum LH and FSH was observed in subjects ovariectomized during luteal phase of the cycle. The quantitative secretion (area under the curve) during the 1st wk after ovariectomy was significantly greater in patients operated on during the follicular phase than during the luteal phase for both LH (P <0.05) and FSH (P <0.01). Thereafter, a similar pattern of gonadotropin rise was observed for patients ovariectomized during either phase of the cycle and reached a plateau by the end of the 3rd wk. At this time, the mean LH concentration increased 6-fold for follicular phase surgery and 8-fold for luteal phase surgery. The mean serum FSH concentration increased 8-fold for follicular phase surgery and 12-fold for luteal phase surgery. The net increase in serum FSH level was higher than that in the serum LH level after surgery in both phases of the cycle and thus a reversal of FSH/LH ratio occurred. These data provide indirect evidence that the phase of ovarian steroid secretion may exert a quantitative influence on the gonadotropin turnover rate within the hypothalamic-pituitary system. The augmented gonadotropin release and the reversal of FSH/ Dr. Tsai is a Research Fellow in Reproductive Endocrinology.

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Section: Resultsmentioning

confidence: 94%

The effect of ovariectomy on gonadotropin release

Yen¹,

Tsai²

1971

J. Clin. Invest.

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“…It has been well established that there is a significant increase in pituitary FSH in the post-menopausal female which occurs simultaneously with an impaired ovarian sex steroid synthesis (Bahn et al 1953). A significant increase in the urinary excretion of bioassayable total gonadotrophin in post-menopausal wo¬ men was demonstrated by Albert (1956).…”

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confidence: 97%

Pituitary Lh and FSH Secretion and Responsiveness in Women of Old Age

Scáglia

Medina

Pinto-Ferreira

et al. 1976

Acta Endocrinologica

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The plasma concentrations and episodic fluctuations of immunoreactive FSH and LH as well as the pituitary sensitivity to LH-RH stimulation were evaluated in post-menopausal women. The subjects were divided into 4 groups according to age. Group 1: 60-70 years old (n= 11), group 2: 70-80 years old (n=22), group 3: 80-90 years old (n=31) and group 4: 90-100 years old (n = 8). Standards used in gonadotrophin radioimmunoassays included the LER-907 preparation and a pooled post-menopausal serum. Since it was found that circulating gonadotrophins have an immunological pattern different from that shown by the pituitary preparation, the results were expressed in mIU/ml calculated accordingly to the immunological behaviour of pooled post-menopausal sera. The mean (\m=+-\se) plasma levels of FSH (mIU/ml) were: group 1: 105.9 \ m=+-\9.5, group 2: 149.3 \ m=+-\10.5, group 3: 124.8 \ m=+-\7.1 and group 4: 149.4 \ m=+-\25.3. The mean (\ m=+-\se) plasma levels of LH (mIU/ml) were: group 1: 81.9 \ m=+-\12.5, group 2: 95.4 \ m=+-\ 9.9, group 3: 84.3 \ m=+-\ 7.7 and group 4: 113.5 \ m=+-\ 19.1. No statistically significant differences were observed among the 4 groups. One patient from each group was randomly selected in order to evaluate their LH and FSH episodic release as well as their pituitary responsiveness to

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Combined bioassay and histological study of 73 human hypophyses

Russfield

1960

Cancer

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Gonadotropins of the Pituitary of Postmenopausal Women

Cited by 15 publications

References 0 publications

The effect of ovariectomy on gonadotropin release

The effect of ovariectomy on gonadotropin release

Pituitary Lh and FSH Secretion and Responsiveness in Women of Old Age

Combined bioassay and histological study of 73 human hypophyses

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