Gonadotropin-releasing hormone neuropeptides and receptor in human breast cancer: Correlation to poor prognosis parameters

Pazaitou‐Panayiotou, Kalliopi; Chemonidou, Christina; Poupi, Aliki; Koureta, Maria; Kaprara, Athina; Lambropoulou, María; Constantinidis, Theodoros C.; Galaktidou, Grammati; Koffa, Maria; Kiziridou, Anastasia; Kakolyris, Stylianos; Kolios, George; Kortsaris, Alexandros; Chatzaki, Εkaterini

doi:10.1016/j.peptides.2012.12.016

Cited by 11 publications

(10 citation statements)

References 34 publications

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“…[6,7] Surgical anesthesia methods might be closely related to cellular immunity in the body, and all these hormones and receptors mentioned above could inhibit the activities of immune cells, natural killer (NK) cells, and humoral immune cells. [8,9] …”

Section: Introductionmentioning

confidence: 99%

Effects of combined epidural and general anesthesia on intraoperative hemodynamic responses, postoperative cellular immunity, and prognosis in patients with gallbladder cancer

Zhu¹,

Zhang²,

Hu³

2017

Medicine

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Background:This study is supposed to investigate the effects of combined epidural and general anesthesia on intraoperative hemodynamic responses, postoperative cellular immunity, and prognosis in patients with gallbladder cancer (GBC).Methods:One hundred forty-four GBC patients were selected and randomly divided into the general anesthesia (GA) group and the combined epidural-general anesthesia (CEGA) group. Before anesthesia induction (t0), at intubation (t1), at the beginning of surgery (t2), 5 minutes after pneumoperitoneum (t3), at the end of surgery (t4), after recovery of spontaneous breathing (t5), after regaining consciousness (t6), and after extubation (t7), the heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and the depth of anesthesia (bispectral index [BIS]) were detected. Blood samples were separately collected 30 minutes before anesthesia induction (T1), 2 hours after the beginning of surgery (T2), at the end of surgery (T3), 1 day after surgery (T4), 3 days after surgery (T5). The survival rates of T cell subsets (CD3+, CD4+, CD8+, CD4+/CD8+) and natural killer (NK) cells were determined by flow cytometry. Postoperative nausea and vomiting (PONV), visual analog scale (VAS), and sedation-agitation scale (SAS) were performed to assess postoperative adverse reactions. A 3-year follow-up was conducted.Results:Compared with the GA group, the CEGA group had significant lower SBP values at t5 and t6, lower DBP values at t1, t3, t4, and t5, lower HR values at t1 and t5, and higher BIS values at t4, t5, t6, and t7. No PONV was observed in the CEGA group. In comparison to the GA group, the VAS was markedly increased and survival rates of CD3+, CD4+, and CD4+/CD8+ cells were increased at T2, T3, T4, and T5 in the CEGA group. The 1-year, 2-year, and 3-year survival rates were not evidently different between the CEGA group and the GA group.Conclusion:Our study provides evidence that the combined epidural-general anesthesia might attenuate intraoperative hemodynamic responses and improve postoperative cellular immunity, so that it might be a more available anesthesia method for GBC patients.

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Section: Introductionmentioning

confidence: 99%

Effects of combined epidural and general anesthesia on intraoperative hemodynamic responses, postoperative cellular immunity, and prognosis in patients with gallbladder cancer

Zhu¹,

Zhang²,

Hu³

2017

Medicine

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“…Fibrinogen alpha chain may also be a prognostic marker for colorectal cancer [46] and tachykinin, precursor which was found to be 99% sensitive for non‐small cell lung cancer in a recent study [47], may also be associated with the disease. Our results also show that Prorelaxin H1 (REL1_HUMAN), which controls the in‐vitro invasive potential of breast cancer [48], may have temporal association with Gonadotropin‐releasing hormone II (GON2_HUMAN), which is a key biomarker in breast cancer [49] and ovarian cancer prognosis [50, 51].…”

Section: Experimental Study and Resultsmentioning

confidence: 82%

In silico discovery of significant pathways in colorectal cancer metastasis using a two‐stage optimisation approach

2015

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Accurate and reliable modelling of protein-protein interaction networks for complex diseases such as colorectal cancer can help better understand mechanism of diseases and potentially discover new drugs. Different machine learning methods such as empirical mode decomposition combined with least square support vector machine, and discrete Fourier transform have been widely utilised as a classifier and for automatic discovery of biomarkers for the diagnosis of the disease. The existing methods are, however, less efficient as they tend to ignore interaction with the classifier. In this study, the authors propose a two-stage optimisation approach to effectively select biomarkers and discover interactions among them. At the first stage, particle swarm optimisation (PSO) and differential evolution (DE) are used to optimise parameters of support vector machine recursive feature elimination algorithm, and dynamic Bayesian network is then used to predict temporal relationship between biomarkers across two time points. Results show that 18 and 25 biomarkers selected by PSO and DE-based approach, respectively, yields the same accuracy of 97.3% and F1-score of 97.7 and 97.6%, respectively. The stratified analysis reveals that Alpha-2-HS-glycoprotein was a dominant hub gene with multiple interactions to other genes including Fibrinogen alpha chain, which is also a potential biomarker for colorectal cancer.

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“…The presence of hGnRH-I, hGnRH-II, and hGnRHR-I has been demonstrated in tumors of the reproductive tract, such as ovarian cancer (96–98), prostate cancer (99–101), and BC (102–104).…”

Section: Physiology Of Gnrh-i Gnrh-ii and Hgnrhr-i In Bcmentioning

confidence: 99%

Treatment of Breast Cancer With Gonadotropin-Releasing Hormone Analogs

et al. 2019

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Although significant progress has been made in the implementation of new breast cancer treatments over the last three decades, this neoplasm annually continues to show high worldwide rates of morbidity and mortality. In consequence, the search for novel therapies with greater effectiveness and specificity has not come to a stop. Among the alternative therapeutic targets, the human gonadotropin-releasing hormone type I and type II (hGnRH-I and hGnRH–II, respectively) and its receptor, the human gonadotropin-releasing hormone receptor type I (hGnRHR-I), have shown to be powerful therapeutic targets to decrease the adverse effects of this disease. In the present review, we describe how the administration of GnRH analogs is able to reduce circulating concentrations of estrogen in premenopausal women through their action on the hypothalamus–pituitary–ovarian axis, consequently reducing the growth of breast tumors and disease recurrence. Also, it has been mentioned that, regardless of the suppression of synthesis and secretion of ovarian steroids, GnRH agonists exert direct anticancer action, such as the reduction of tumor growth and cell invasion. In addition, we discuss the effects on breast cancer of the hGnRH-I and hGnRH-II agonist and antagonist, non-peptide GnRH antagonists, and cytotoxic analogs of GnRH and their implication as novel adjuvant therapies as antitumor agents for reducing the adverse effects of breast cancer. In conclusion, we suggest that the hGnRH/hGnRHR system is a promising target for pharmaceutical development in the treatment of breast cancer, especially for the treatment of advanced states of this disease.

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Gonadotropin-releasing hormone neuropeptides and receptor in human breast cancer: Correlation to poor prognosis parameters

Cited by 11 publications

References 34 publications

Effects of combined epidural and general anesthesia on intraoperative hemodynamic responses, postoperative cellular immunity, and prognosis in patients with gallbladder cancer

Effects of combined epidural and general anesthesia on intraoperative hemodynamic responses, postoperative cellular immunity, and prognosis in patients with gallbladder cancer

In silico discovery of significant pathways in colorectal cancer metastasis using a two‐stage optimisation approach

Treatment of Breast Cancer With Gonadotropin-Releasing Hormone Analogs

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