Gonadotropin-releasing hormone agonist treatment reduced serum interleukin-6 concentrations in patients with ovarian endometriomas

Iwabe, Tomio; Harada, Tasuku; Sakamoto, Yoko; Iba, Yumiko; Horie, Sayako; Mitsunari, Masahiro; Terakawa, Naoki

doi:10.1016/s0015-0282(03)00609-5

Cited by 44 publications

(43 citation statements)

References 16 publications

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“…Elevated serum IL-6 levels observed in cases of MM endometriosis in our study confirm findings of some reports (Bedaiwy et al, 2002) but diverge with those of others who found no value for serum IL-6 in the diagnosis of any stage of endometriosis (D'Hooghe et al, 2001;Somigliana et al, 2004) reports. Our results also challenge reports of higher serum IL-6 in endometriomas than other benign ovarian cysts (Daraï et al, 2003;Iwabe et al, 2003).…”

Section: Discussioncontrasting

confidence: 51%

“…Our group described for the first time an elevation of serum IL-6 levels in infertile women with endometriosis with respect to controls (Pellicer et al, 1998). The findings of this study were endorsed in some subsequent studies (Bedaiwy et al, 2002;Iwabe et al, 2003), whereas others failed to detect such a difference (D'Hooghe et al, 2001;Somigliana et al, 2004). The stage of the disease did not affect serum IL-6 levels, thus discrediting this cytokine as a reliable marker of MM endometriosis (D'Hooghe et al, 2001;Bedaiwy et al, 2002).…”

Section: Introductionsupporting

confidence: 65%

“…As evidence shows that estrogens affect IL-6 secretion in menopausal women and ovariectomy increases systemic levels of IL-6 in animals (Yokose et al, 1996), we considered the stage of the cycle to be relevant. That said, others have evaluated this particular issue and described no difference between cycle phases in the secretion of serum IL-6 (Bedaiwy et al, 2002;Daraï et al, 2003;Iwabe et al, 2003). Thus, this should not be an issue.…”

Section: Discussionmentioning

confidence: 99%

“…In this way, the subject remains, to some extent, up in the air. That said, reports that women with endometriomas have higher serum IL-6 levels than controls (Iwabe et al, 2003), and women with benign ovarian cysts (Daraï et al, 2003), would suggest that women with moderatesevere (MS) rather than MM endometriosis are those that present high levels of serum IL-6.…”

Section: Introductionmentioning

confidence: 99%

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Serum interleukin-6 levels are elevated in women with minimal–mild endometriosis

Martínez¹,

Garrido²,

Coperias³

et al. 2006

Human Reproduction

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BACKGROUND: There is a need for a reliable marker of endometriosis, especially in early stages of peritoneal disease during which imaging is not effective. The use of serum interleukin (IL)-6 as a marker is controversial. To readdress the matter, patients undergoing laparoscopy were prospectively evaluated for serum IL-6 levels. MATERIALS AND METHODS: A total of 119 women 31 years old who underwent laparoscopy were divided into groups: control patients (n = 38) with no pathologic findings; endometriosis sufferers (n = 47) with minimal-mild (MM, n = 11) or moderate-severe (MS, n = 36) endometriosis; uterine myomas (n = 13) and benign ovarian pathologies (n = 21). Blood was drawn on cycles days 5-12 and stored for subsequent analysis of IL-6 and carbohydrate antigen (CA)-125 levels. RESULTS: Serum IL-6 levels were significantly (P = 0.002) higher in women with MM endometriosis (29.4 ± 9.0 pg/ml) than in controls (15.7 ± 9.3 pg/ml). When all the non-endometriosis patients were grouped together (n = 72) and serum IL-6 (17.8 ± 12.1 pg/ml) compared with MS (n = 36; 17.6 ± 10.3 pg/ml) and MM (n = 11; 29.4 ± 9.0 pg/ml) endometriosis significantly (P < 0.01) higher levels in MM endometriosis were observed as compared to the other two groups. Serum Ca-125 levels were significantly (P < 0.01) elevated in MS endometriosis. A serum IL-6 threshold of 25.75 pg/ml afforded a sensitivity of 75% and specificity of 83% in the diagnosis of MM endometriosis. Sensitivity and specificity for CA-125 in the diagnosis of MS endometriosis, using 35 IU/ml as the cut-off value, were 47% and 97%, respectively. CONCLUSIONS: IL-6 is a reliable non-invasive marker of MM endometriosis, whereas Ca-125 is of use as a marker of severe cases.

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Section: Discussioncontrasting

confidence: 51%

Section: Introductionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum interleukin-6 levels are elevated in women with minimal–mild endometriosis

Martínez¹,

Garrido²,

Coperias³

et al. 2006

Human Reproduction

View full text Add to dashboard Cite

show abstract

“…In fact, no statistically significant differences are reported between controls and endometriosis www.intechopen.com patients. In contrast, serum levels of IL-6 were significantly higher in women with endometriosis than in controls and the highest levels were found in women with chocolate cysts (Wieser et al, 2003;Iwabe et al, 2003).…”

Section: Cytokinesmentioning

confidence: 65%