Gonadotropin Releasing Hormone Agonist Final Oocyte Maturation and Human Chorionic Gonadotropin as Exclusive Luteal Support in Normal Responders

Beck-Fruchter, Ronit; Baram, Shira; Geslevich, Yoel; Weiss, Amir

doi:10.1159/000490946

Cited by 2 publications

(3 citation statements)

References 35 publications

(56 reference statements)

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“…However, insufficient evidence is available regarding the impact of a GnRHa or a dual trigger on normal responders. A recent observational study reported cycle outcomes following a Gn-RHa trigger with exclusive hCG support in a progesterone-free luteal phase, and the results were comparable to those of cycles triggered by hCG [8]. This study was rare in that it supported a GnRHa trigger as a valid alternative in normal responders.…”

Section: Introductionmentioning

confidence: 71%

“…They also reported nonsignificant trends towards higher implantation, clinical pregnancy, and live delivery rates in the dual-trigger group compared to the hCG-trigger group [24]. In another recent study, Beck-Fruchter et al [8] compared the results following a Gn-RHa trigger and an hCG trigger in normal responders. The authors reported similar outcomes regarding the number of oocytes, oocyte maturation rate, implantation rate, and live birth rate [8].…”

Section: Discussionmentioning

confidence: 98%

“…In another recent study, Beck-Fruchter et al [8] compared the results following a Gn-RHa trigger and an hCG trigger in normal responders. The authors reported similar outcomes regarding the number of oocytes, oocyte maturation rate, implantation rate, and live birth rate [8]. Our results aligned with the results of these two recent studies in that a dual trigger was superior to an hCG trigger alone.…”

Section: Discussionmentioning

confidence: 99%

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Dual trigger in normally-responding assisted reproductive technology patients increases the number of top-quality embryos

Şükür

Ulubaşoğlu

İlhan³

et al. 2020

Clin Exp Reprod Med

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Objective: The feasibility of a gonadotropin-releasing hormone agonist (GnRHa) trigger in normal responders is still a matter of debate. The aim of this study was to compare the number of mature oocytes, the number of good-quality embryos, and the live birth rate in normal responders triggered by GnRHa alone, GnRHa and human chorionic gonadotropin (hCG; a dual trigger), and hCG alone.Methods: A retrospective cohort study was conducted at the infertility clinic of a university hospital. Data from 200 normal responders who underwent controlled ovarian hyperstimulation and intracytoplasmic sperm injection with a GnRH antagonist protocol between January 2016 and January 2017 were reviewed. The first study group consisted of patients with cycles triggered by GnRHa alone. The second study group consisted of patients with cycles triggered by both GnRHa and low-dose hCG (a dual trigger). The control group consisted of patients with cycles triggered by hCG alone.Results: The groups were comparable in terms of demographics and cycle characteristics. The numbers of total oocytes retrieved and metaphase II oocytes were similar between the groups. The total numbers of grade A embryos were 3.2±2.9 in the GnRHa group, 4.4±3.2 in the dual-trigger group, and 2.9±2.1 in the hCG group (p=0.014). The live birth rates were 21.4%, 30.5%, and 28.2% in those groups, respectively (p=0.126).Conclusion: In normal responders, a dual-trigger approach appears superior to an hCG trigger alone with regard to the number of top-quality embryos produced. However, no clinical benefit was apparent in terms of live birth rates.

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Section: Introductionmentioning

confidence: 71%