Gonadotropin and Estradiol Levels after Leuprolide Stimulation Tests in Brazilian Girls with Precocious Puberty

Junqueira, Flávia Raquel Rosa; Lara, Lúcia Alves da Silva; Martins, Wellington P.; Ferriani, Rui Alberto; Rosa-e-Silva, A.C.J.S.; Sá, Marcos Felipe Silva de; Reis, Rosana Maria dos

doi:10.1016/j.jpag.2014.09.006

Cited by 4 publications

(4 citation statements)

References 27 publications

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“…evidencia La determinación del estradiol puede mejorar el rendimiento diagnóstico de la prueba de estímulo con un aGnRH cuando se realiza entre las 18 y 24 horas posteriores. Se ha reportado que los valores de estradiol > 52.9 pg/ml a las 24 horas del estímulo con un aGnRH muestran una Sen del 68-84% y una Esp del 74-100% para identificar PP 3,15 . Sathasivam, et al 15 reportaron que agregar la determinación del estradiol con un punto de corte > 50 pg/ml a la prueba de estimulación con un aGnRH permite alcanzar una Sen y una Esp del 100%.…”

Section: Evidenciaunclassified

“…recomendación 1.1. Se recomienda considerar la realización de estudios complementarios para el diagnóstico de pubertad precoz central en pacientes que inician con desarrollo de caracteres sexuales secundarios antes de los 8 años en niñas (telarca) y antes de los 9 años en niños (volumen testicular ≥ 4 cm 3 ). (Recomendación condicional | Nivel de evidencia: II OCEBM.)…”

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“…Se ha descrito que del 21 al 64% de las niñas que inician con el desarrollo del botón mamario antes de los 8 años de edad presentan una telarca aislada y no evolucionan a PPC 2,3 . Junqueira, et al 3 reportaron una probabilidad del 36% de progresión de telarca aislada hacia PPC, del 50% de pubarca prematura y del 72.2% de la combinación de ambas características. Otros hallazgos clínicos asociados a la PPC pueden ser la aceleración de la velocidad de crecimiento, la progresión de más de un estadio de Tanner en 6 meses o la no regresión de caracteres sexuales secundarios 4 .…”

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Diagnóstico de pubertad precoz: Guía de práctica clínica para el diagnóstico y el tratamiento de la pubertad precoz

Miranda-Lora¹,

Torres-Tamayo²,

Zurita‐Cruz³

et al. 2020

BMHIM

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The Mexican Society of Pediatric Endocrinology developed a clinical practice guide for the diagnosis and treatment of precocious puberty. This document presents recommendations related to the diagnosis of precocious puberty. The detailed description of the methodology for the development of this guide and the grading system, as well as the synthesis of the evidence on which it is based can be accessed in this same supplement.

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Diagnóstico de pubertad precoz: Guía de práctica clínica para el diagnóstico y el tratamiento de la pubertad precoz

Miranda-Lora¹,

Torres-Tamayo²,

Zurita‐Cruz³

et al. 2020

BMHIM

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“…Kisspeptin antagonists have potential clinical applications in patients suffering from diseases associated with enhanced LH pulse frequency, such as polycystic ovary syndrome, menopause, or precocious puberty [1,23]. Central infusion of peptide-234 in pubertal female rats decreased uterine and ovarian weight, and delayed vaginal opening (an indicator of puberty), without affecting body weight [24].…”

Section: Kisspeptin Antagonistsmentioning

confidence: 99%

Kisspeptin and neurokinin B analogs use in gynecological endocrinology: where do we stand?

Szeliga

Podfigurna

Bala

et al. 2019

J Endocrinol Invest

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Background Recent studies have found that kisspeptin/neurokinin B/dynorphin neurons (KNDy neurons) in the infundibular nucleus play a crucial role in the reproductive axis. Analogs, both agonists and antagonists, of kisspeptin and neurokinin B (NKB) are particularly important in explaining the physiological role of KNDy in the reproductive axis in animals. The use of kisspeptin and NKB analogs has helped elucidate the regulators of the hypothalamic reproductive axis. Purpose This review describes therapeutic uses of Kiss-1 and NKB agonists, most obviously the use of kisspeptin agonists in the treatment for infertility and the induction of ovulation. Kisspeptin antagonists may have potential clinical applications in patients suffering from diseases associated with enhanced LH pulse frequency, such as polycystic ovary syndrome or menopause. The inhibition of pubertal development using Kiss antagonists may be used as a therapeutic option in precocious puberty. Kisspeptin antagonists have been found capable of inhibiting ovulation and have been proposed as novel contraceptives. Hypothalamic amenorrhea and delayed puberty are conditions in which normalization of LH secretion may potentially be achieved by treatment with both kisspeptin and NKB agonists. NKB antagonists are used to treat vasomotor symptoms in postmenopausal women, providing rapid relief of symptoms while supplanting the need for exogenous estrogen exposure. Conclusions There is a wide spectrum of therapeutic uses of Kiss-1 and NKB agonists, including the management of infertility, treatment for PCOS, functional hypothalamic amenorrhea or postmenopausal vasomotor symptoms, as well as contraceptive issues. Nevertheless, further research is needed before kisspeptin and NKB analogs are fully incorporated in clinical practice.

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Telomere length is not altered in girls with idiopathic central precocious puberty treated with a GnRH analog – leuprolide acetate

Furtado

Iannetta

Ferriani

et al. 2020

Gynecological Endocrinology

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Gonadotropin and Estradiol Levels after Leuprolide Stimulation Tests in Brazilian Girls with Precocious Puberty

Cited by 4 publications

References 27 publications

Diagnóstico de pubertad precoz: Guía de práctica clínica para el diagnóstico y el tratamiento de la pubertad precoz

Diagnóstico de pubertad precoz: Guía de práctica clínica para el diagnóstico y el tratamiento de la pubertad precoz

Kisspeptin and neurokinin B analogs use in gynecological endocrinology: where do we stand?

Telomere length is not altered in girls with idiopathic central precocious puberty treated with a GnRH analog – leuprolide acetate

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