Gonadotrophic and Thyrotrophic Cells of the Pituitary Gland of the Ferret

Holmes, Robert L.

doi:10.1677/joe.0.0250495

Cited by 18 publications

(8 citation statements)

References 19 publications

(23 reference statements)

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“…The absence of any changes in the acidophils of gonadectomized shrews is in agreement with findings in the ferret (Holmes, 1963), rabbit (Foster & Cameron, 1964), slender loris (Anand Kumar, 1967) and sheep (Mikami & Diamon, 1968). …”

Section: Effect Ofgonadectomysupporting

confidence: 88%

“…The rapid degranulation of the gonadotrophs ofthe shrew hypophysis after gonadectomy is comparable to observations made in the rabbit (Foster & Cameron, 1964) and ferret (Holmes, 1963). In contrast to the rabbit, however, in which well-granulated cells secreting LH do not appear until 4 months after gonadectomy (Foster & Cameron, 1964), in the gonadectomized musk shrew regranulation of the gonadotrophs occurs about 3 weeks after the operation.…”

Section: Effect Ofgonadectomysupporting

confidence: 78%

“…The marked differential response of the two types of gonadotrophin-secreting cells after gonadectomy as reported for the rat (Allanson & Parkes, 1966), mouse (Barnes, 1963) and rabbit (Foster & Cameron, 1964) was not observed in the present study. The development of vacuolated cells after gonadectomy, which has been observed in the rat (Purves, 1966) and the slender loris (Anand Kumar, 1967) does not occur in the musk shrew; these cells are also absent in the rabbit (Foster & Cameron, 1964), ferret (Holmes, 1963), palm squirrel (Dhaliwal & Prasad, 1965a), guinea-pig (D'Angelo, 1963) and sheep (Mikami & Daimon, 1968). The absence of conspicuous hypertrophy of the gonadotrophs in the shrew is in agreement with observations made in the rabbit (Foster & Cameron, 1964).…”

Section: Effect Ofgonadectomymentioning

confidence: 96%

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Functional Significance of the Cells in the Pars Anterior of the Pituitary Gland of the Musk Shrew (Suncus Murinus L.)

Naik¹,

Dominic²

1978

Journal of Endocrinology

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Seven morphologically and tinctorially distinct types of cells (types 1--7) have been distinguished in the pars anterior of the pituitary gland of the musk shrew (Suncus murinus L.). On the basis of their responses to various experimental stimuli, these cell types were correlated with the secretion of various trophic hormones. Type 1 cells exhibited conspicuous changes after thyroidectomy or inactivation of the thyroid gland and hence appeared to be the source of TSH. Types 2 and 3 cells responded to gonadectomy and administration of androgens, which suggests that they were associated with gonadotrophin secretion. The granules of the type 2, but not the type 3 cells could be extracted with 10% trichloroacetic acid, which may indicate that type 2 and 3 cells secrete FSH and LH respectively. After the administration of either reserpine or oestrogen, the type 4 cells underwent hypertrophy and hyperplasia, which suggests that they were the likely source of prolactin. Type 6 cells, which are distinguishable from type 4 cells by their thinly dispersed erythrosinophilic granulation, showed conspicuous changes after unilateral adrenalectomy, administration of metyrapone or exposure to stress and may therefore be responsible for secretion of ACTH. Type 5 cells tinctorially resembled the somatotrophic cells of other mammalian species and did not respond to any of the experimental treatments used in the present study. It is therefore possible that these cells have a somatotrophic function. The possible significance of type 7 cells has been discussed previously.

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Section: Effect Ofgonadectomysupporting

confidence: 88%

Section: Effect Ofgonadectomysupporting

confidence: 78%

Section: Effect Ofgonadectomymentioning

confidence: 96%

See 1 more Smart Citation

Functional Significance of the Cells in the Pars Anterior of the Pituitary Gland of the Musk Shrew (Suncus Murinus L.)

Naik¹,

Dominic²

1978

Journal of Endocrinology

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“…Sexually quiescent animals had fewer gonadotropes than fertile ones; gonadotropes that were recognizable contained less stainable hormone, a finding widely reported in other species (Hoffman and Zarrow, 1958;Holmes, 1959Holmes, , 1963Clarke and Forsyth, 1964;Charlton and Worth, 1975). During the breeding season, or in photoperiods that simulate breeding, there have also been reports of elevations in plasma gonadotropin concentration (Ellis and Follett, 1983;Urbanski et al, 1983;McNatty et al, 1984).…”

Section: Gland Weightsupporting

confidence: 55%

Adenohypophysis of the elephant seal (Mirounga leonina): Morphology and seasonal histological changes

Griffiths

Bryden

1986

Am. J. Anat.

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Changes in adenohypophyseal cell populations over a 12-month period were studied in the seasonally breeding elephant seal (24 adult males, 3 adult females, and 5 neonates) at Macquarie Island. The glands were weighed and fixed in formol sublimate. Selected sections were stained with the oxidation-alcian blue-periodic acid Schiff-orange G technique. Gonadotropic, thyrotropic, lactotropic, and somatotropic cells were readily identifiable; whilst corticotropes, inactive secretory cells of all types, and stellate cells were not stained and were counted collectively as chromophobic cells. Hypophyseal weight was low throughout autumn and winter, but increased significantly during the spring breeding season and the summer. Thyrotropes were distributed evenly throughout the pars distalis, but the other secretory cells showed areas of concentration. Acidophils were common peripherally, particularly lactotropes, while gonadotropes were largely confined to the 'basophilic wedge,' a narrow, central superior zone. In males, lactotropic and gonadotropic cells showed significant seasonal changes in number. Gonadotropes were more common in sexually active males than sexually quiescent ones, while lactotrope numbers were much greater at midsummer than midwinter. This lactotrope cycle appeared to be related to photoperiod but unrelated to breeding.

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“…They are synonymous with the 'beta' cells of Halmi (Halmi, 1952) and are called thyrotrophs by Purves & Griesbach (1954, 1957. They are similar to the Type II, Alcian bluepositive cells of the ferret (Holmes, 1963). The term ' thyrotroph ' is considered to be a more descriptive name and was therefore adopted.…”

Section: Resultsmentioning

confidence: 99%

Weight and Histology of the Pituitary Gland in Castrated Male Rats With Hypothalamic Lesions

Montemurro¹

1964

Journal of Endocrinology

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The effect of bilateral electrolytic lesions in the ventral hypothalamus at the coronal level of the posterior ventromedial nucleus and anterior premammillary nucleus on the weight and cytology of the pituitary gland of castrated male Lewis rats was investigated. All castrated rats were carrying successful intrasplenic isologous grafts of neonatal testes. The hypothalamic lesions resulted in a significant inhibition of pituitary hypertrophy in the castrated animals, but did not alter appreciably the cytology of the gland as compared with that of castrated rats without hypothalamic damage. The development of castration cells was not impaired by these lesions.It is concluded that hypertrophy of the pituitary gland after castration and the development of castration cells are two manifestations ofthe pituitary response to a low concentration of circulating testicular hormone. The former requires the integrity of the posteroventral hypothalamus while the latter is independent of this hypothalamic region.

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Gonadotrophic and Thyrotrophic Cells of the Pituitary Gland of the Ferret

Cited by 18 publications

References 19 publications

Functional Significance of the Cells in the Pars Anterior of the Pituitary Gland of the Musk Shrew (Suncus Murinus L.)

Functional Significance of the Cells in the Pars Anterior of the Pituitary Gland of the Musk Shrew (Suncus Murinus L.)

Adenohypophysis of the elephant seal (Mirounga leonina): Morphology and seasonal histological changes

Weight and Histology of the Pituitary Gland in Castrated Male Rats With Hypothalamic Lesions

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