Gonadal hormone modulation of hippocampal neurogenesis in the adult

Galea, Liisa A.M.; Spritzer, Mark D.; Barker, Jennifer M.; Pawluski, Jodi L.

doi:10.1002/hipo.20154

Cited by 214 publications

(152 citation statements)

References 64 publications

Supporting

Mentioning

144

Contrasting

Unclassified

Order By: Relevance

“…Thus, it is of particular interest that deletion of MOR appears to confer a survival advantage to maturing neurons without altering the numbers of proliferating progenitor cells. These data add MOR to the limited list of factors that have a stronger effect on survival versus proliferation of new hippocampal neurons (Ambrogini et al, 2005, Rizk et al, 2005, Galea et al, 2006, Lichtenwalner et al, 2006. The data presented here suggest that MOR is critical to normal maturation of adult-generated granule cells.…”

Section: Discussionsupporting

confidence: 52%

“…This multiple opioid receptor antagonism could mask MOR-specific effects. Contradictory results have also been found with naltrexone's effects on cell proliferation in the SGZ (Persson et al, 2004, Galea et al, 2006, emphasizing the complexity of in vivo use of this compound, and the general challenges associated with attempts to mimic genetic manipulation with pharmacological blockade. Future studies will circumvent the natural confounds associated with constitutive KOs and the non-specificity of available MOR antagonists by studying the link between MOR and cell survival in a conditional MOR KO mouse.…”

Section: Possible Mechanisms For Mor Regulation Of Neurogenesismentioning

confidence: 99%

See 1 more Smart Citation

Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons

Harburg¹,

Hall²,

Harrist³

et al. 2007

Neuroscience

View full text Add to dashboard Cite

Recent evidence suggests that mu opioid receptors (MOR) are key regulators of hippocampal structure and function. For example, exogenous MOR agonists morphine and heroin negatively impact hippocampal function and decrease adult hippocampal neurogenesis. Here we explored the role of MOR in the birth and survival of hippocampal progenitor cells by examining adult neurogenesis in mice that lack MOR. Adult male mice lacking exon 1 of MOR were injected with the S phase marker bromodeoxyuridine (BrdU) and sacrificed either two hours or four weeks later to evaluate proliferating and surviving BrdU-immunoreactive (IR) cells, respectively, in the adult hippocampal granule cell layer. WT, heterozygote, and homozygote mice did not differ in the number of BrdU-IR cells at a proliferation time point. However, four weeks after BrdU injection, heterozygote and homozygote mice had 57% and 54% more surviving BrdU-IR cells in the hippocampal granule cell layer as compared to WT mice. A decrease in apoptosis in the heterozygote and homozygote mice did not account for the difference in number of surviving BrdU-IR cells since there were no alterations in number of pyknotic, TUNEL-positive, or activated caspase 3-IR cells compared to WT. In concordance with the increased numbers of granule cells maturing into neurons, heterozygote and homozygote mice had larger hippocampal granule cell layers and increased numbers of granule cells. These findings indicate that MOR may play a role in regulating progenitor cell survival and more generally encourage further exploration of how MOR activation can influence hippocampal structure and function.

show abstract

Section: Discussionsupporting

confidence: 52%

Section: Possible Mechanisms For Mor Regulation Of Neurogenesismentioning

confidence: 99%

Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons

Harburg¹,

Hall²,

Harrist³

et al. 2007

Neuroscience

View full text Add to dashboard Cite

show abstract

“…Possible mechanisms for these micro-cellular changes include synaptogenesis, angiogenesis and hypertrophy (Hagemann et al, 2011;Zatorre et al, 2012). Estrogen is known to affect cell proliferation as well as cell survival in the hippocampus in adult female animals (Galea et al, 2006;Pawluski et al, 2009). Hippocampal estrogen receptors have been proposed as one pathway of estrogen effects on neural plasticity (Spencer et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Hippocampal volume and functional connectivity changes during the female menstrual cycle

et al. 2015

View full text Add to dashboard Cite

Hippocampal volume has been shown to be sensitive to variations in estrogen and progesterone levels across rodents' estrous cycle. However, little is known about the covariation of hormone levels and brain structure in the course of the human menstrual cycle. Here, we examine this covariation with a multi-method approach that includes several brain imaging methods and hormonal assessments. We acquired structural and functional scans from 21 naturally cycling women on four time points during their cycles (early follicular phase, late follicular phase, ovulation and luteal phase). Hormone blood concentrations and cognitive performance in different domains were assessed on each of the measurement occasions. Structural MRI images were processed by means of whole-brain voxel-based morphometry and FreeSurfer. With either method, bilateral increases in hippocampal volume were found in the late follicular phase relative to the early follicular phase. The gray matter probability in regions of hippocampal volume increase was associated with lower mean diffusivity in the same region. In addition, we observed higher functional connectivity between the hippocampi and the bilateral superior parietal lobe in the late follicular phase. We did not find any reliable cycle-related performance variations on the cognitive tasks. The present results show that hormonal fluctuations covary with hippocampal structure and function in the course of the human menstrual cycle.

show abstract

“…Thus, it is possible that differences in E 2 or T levels between WCF and CF affected Hp size. It would not be surprising if any housing-induced changes in hormones altered Hp volume in female cowbirds only, given that effects of E 2 on Hp neurogenesis, spinogenesis, and synaptogenesis are low or lacking in male compared to female rats (Galea et al, 2006;Parducz et al, 2006).Even if E 2 affects Hp morphology similarly in male and female cowbirds, unlike the case in rats (Galea et al, 2006;Parducz et al, 2006), captivity could differentially affect male and female hormone profiles. Although both CM and CF were in apparent breeding condition, it is possible that there were sex-specific effects of housing on hormonal profiles in our cowbirds.…”

mentioning

confidence: 99%

Sex differences in the effects of captivity on hippocampus size in brown-headed cowbirds (Molothrus ater obscurus).

Day

Guerra²,

Schlinger³

et al. 2008

Behavioral Neuroscience

View full text Add to dashboard Cite

In brood parasitic cowbirds, hippocampus (Hp) size is correlated with environmental spatial memory demands. Searching for host nests is the presumed causal factor influencing cowbird Hp size, because Hp volumes vary across species, sexes, and seasons according to nest-searching participation. Brownheaded cowbirds have female-only nest searching and, at least in the eastern subspecies, a larger Hp in females than in males, suggesting that nest searching influences cowbird Hp size. We predicted that female brown-headed cowbirds housed in aviaries lacking host nests would have a smaller Hp than wild-caught females whereas males would be unaffected. We found that the Hp was smaller in captive females, but not males, compared to their wild-caught counterparts. This did not appear to be due to general effects of an impoverished environment on all brain regions. Our results imply that interruption of nest searching in cowbirds prevents seasonal increase in Hp size in females. Future studies should isolate which behavioral differences between wild and captive birds contributed to captivity-induced changes in Hp volume in females while not affecting males. Keywordscowbird; hippocampus; sex differences; brain plasticity; brood parasitism Variation in environmental spatial demands is related to variation in hippocampus (Hp) size among closely related species, between sexes, and across seasons in mammalian, avian, and reptilian species. For example, food-storing behaviors in birds (Clayton, 1995a;Hampton, Sherry, Shettleworth, Kurgel, & Ivy, 1995;Hampton & Shettleworth, 1996;Healy & Krebs, 1992;Krebs, Sherry, Healy, Perry, & Vaccarion, 1989;Sherry, Vaccarino, Buckenham, & Herz, 1989;Volman, Grubb, & Schuett, 1997) and rodents (Jacobs, 1992;Jacobs & Spencer, 1994), foraging-related rate of movement in lacertid lizards (Day, Crews, & Wilczynski, 1999), home-range size in voles (Gaulin, 1992;Jacobs, Gaulin, Sherry, & Hoffman, 1990 Sherry, Jacobs, & Gaulin, 1992), and breeding-habitat complexity in petrels (Abbott, Walsh, Storey, Stenhause, & Harley, 1999) are all associated with enlarged Hp size, presumably due to the demands of spatial memory. In addition, seasonal variation in food-storing demands is associated with seasonal changes in Hp volume (Smulders, Sasson, & DeVoogd, 1995) in black-capped chickadees and rodents (Jacobs, 1996). Males have a larger Hp than females in a vole species in which males have larger home ranges but not in vole species that do not have sex differences in home range (Gaulin, 1992). These results provide evidence that environmental or experiential seasonal changes can alter Hp volume and that natural and sexual selection on a variety of spatial-related skills has produced a larger Hp in some species or sexes than in others.Although correlations of Hp volume with ecological demands for spatial ability are numerous, the specific mechanisms that contribute to such adult variation in the volume of the Hp are not well understood. We do know that species-specific reactions to spatial experience...

show abstract

Gonadal hormone modulation of hippocampal neurogenesis in the adult

Cited by 214 publications

References 64 publications

Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons

Knockout of the mu opioid receptor enhances the survival of adult-generated hippocampal granule cell neurons

Hippocampal volume and functional connectivity changes during the female menstrual cycle

Sex differences in the effects of captivity on hippocampus size in brown-headed cowbirds (Molothrus ater obscurus).

Contact Info

Product

Resources

About