Gonad development and plasma steroid profiles by HRGC/HRMS during one reproductive cycle in reference and leachate-exposed female perch (Perca fluviatilis)

Noaksson, Erik; Gustavsson, Bodil; Linderoth, Maria; Zebühr, Yngve; Broman, Dag; Balk, Lennart

doi:10.1016/j.taap.2003.11.017

Cited by 44 publications

(17 citation statements)

References 37 publications

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“…There have been many traditional biochemical studies that have characterised the changes in one or a few endogenous metabolites in environmentally sampled organisms through time. One noteworthy investigation used GC-MS to measure nine steroids in the plasma of female perch (Perca fluviatilis) throughout an annual reproductive cycle (Noaksson et al 2004). Although the authors did not conduct multivariate statistical analysis, the monthly changes in the steroid profiles provided new baseline information about the physiology of female perch.…”

Section: Seasonality and Baseline Metabolismmentioning

confidence: 99%

Environmental metabolomics: a critical review and future perspectives

2008

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Environmental metabolomics is the application of metabolomics to characterise the interactions of organisms with their environment. This approach has many advantages for studying organism-environment interactions and for assessing organism function and health at the molecular level. As such, metabolomics is finding an increasing number of applications in the environmental sciences, ranging from understanding organismal responses to abiotic pressures, to investigating the responses of organisms to other biota. These interactions can be studied from individuals to populations, which can be related to the traditional fields of ecophysiology and ecology, and from instantaneous effects to those over evolutionary time scales, the latter enabling studies of genetic adaptation. This review provides a comprehensive and current overview of environmental metabolomics research. We begin with an overview of metabolomic studies into the effects of abiotic pressures on organisms. In the field of ecophysiology, studies on the metabolic responses to temperature, water, food availability, light and circadian rhythms, atmospheric gases and season are reviewed. A section on ecotoxicogenomics discusses research in aquatic and terrestrial ecotoxicology, assessing organismal responses to anthropogenic pollutants in both the laboratory and field. We then discuss environmental metabolomic studies of diseases and biotic-biotic interactions, in particular herbivory. Finally, we critically evaluate the contribution that metabolomics has made to the environmental sciences, and highlight and discuss recommendations to advance our understanding of the environment, ecology and evolution using a metabolomics approach.

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Section: Seasonality and Baseline Metabolismmentioning

confidence: 99%

Environmental metabolomics: a critical review and future perspectives

2008

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“…Overall, elevated concentrations of 11-deoxycortisol are reported in reproductively cycling fish with concentrations spanning 8-31 ng/ml quantified in female rainbow trout (Salmo gairdneri) and 9-18 ng/g (plasma) in female perch (Perca fluviatilis) during the spawning and post-ovulatory period (i.e. after spawning) [60][61][62]. The lack of significant differences between male and female fathead minnows quantified in our study may be attributed to the fact that fish were maintained as non-spawners in separate tanks.…”

Section: Steroidsmentioning

confidence: 99%

Quantification of 2-hydrazinopyridine derivatized steroid hormones in fathead minnow (Pimephales promelas) blood plasma using LC-ESI+/MS/MS

Hala

Overturf

Petersen

et al. 2011

Journal of Chromatography B

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“…Metabolomic methods can also detect molecules like glutathione and ascorbate, which can change as a function of cellular redox status (Kristal et al 1998). Steroids are another class of molecules that are of considerable interest, and so measurement of oestradiol and ketotestosterone could be used to help inform on the reproductive status of an organism (Noaksson et al 2004). Taken together, as metabolomic technologies are developed to the point where many hundreds of metabolites are measured simultaneously, the exciting potential to rapidly assess many aspects of an organism's current energetic, oxidative and perhaps even reproductive status may be realised.…”

Section: The Dynamic Metabolomementioning

confidence: 99%

Metabolomics of aquatic organisms: the new omics on the block

Viant¹

2007

Mar. Ecol. Prog. Ser.

162

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Environmental metabolomics can be defined as the application of metabolomics to characterise the metabolism of free-living organisms obtained from the natural environment and of organisms reared under laboratory conditions, where those conditions serve to mimic scenarios encountered in the natural environment. This approach has considerable potential for characterising the responses of organisms to natural and anthropogenic stressors. The current essay introduces environmental metabolomics, discusses the challenges of measuring metabolites, and then highlights the dynamic nature of the metabolome that can be exploited to provide a holistic view of an organism's health. Dealing with metabolic variability is a considerable challenge in environmental metabolomics. Here, I propose the concept of a normal metabolic operating range (NMOR), defined as the region in metabolic space in which 95% of individuals from a population reside, with stress identified as a deviation from the NMOR. Furthermore, I emphasise the importance of genotypic and phenotypic anchoring (e.g. knowing species, gender, age) to facilitate interpretation of multivariate metabolomics data.

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Gonad development and plasma steroid profiles by HRGC/HRMS during one reproductive cycle in reference and leachate-exposed female perch (Perca fluviatilis)

Cited by 44 publications

References 37 publications

Environmental metabolomics: a critical review and future perspectives

Environmental metabolomics: a critical review and future perspectives

Quantification of 2-hydrazinopyridine derivatized steroid hormones in fathead minnow (Pimephales promelas) blood plasma using LC-ESI+/MS/MS

Metabolomics of aquatic organisms: the new omics on the block

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Gonad development and plasma steroid profiles by HRGC/HRMS during one reproductive cycle in reference and leachate-exposed female perch (Perca fluviatilis)

Cited by 44 publications

References 37 publications

Environmental metabolomics: a critical review and future perspectives

Environmental metabolomics: a critical review and future perspectives

Quantification of 2-hydrazinopyridine derivatized steroid hormones in fathead minnow (Pimephales promelas) blood plasma using LC-ESI+/MS/MS

Metabolomics of aquatic organisms: the new omics on the block

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Metabolomics of aquatic organisms: the new omics on the block