Golgi protein 73, hepatocellular carcinoma and other types of cancers

Wang, Yanan; Wan, Yu

doi:10.1016/j.livres.2020.09.003

Cited by 19 publications

(11 citation statements)

References 82 publications

(94 reference statements)

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“…AFP-L3 is a PHC-specific marker, mainly secreted by hepatoma cells and able to enter the blood circulation [ 12 ]. GP73 is a Golgi type II transmembrane protein, and several researchers have pointed out that its concentration in the serum of PHC patients is increased [ 14 , 23 , 28 ]. When liver cancer occurs, its cells cannot make good use of vitamin K, resulting in a decrease in the activity of vitamin K-dependent γ -glutamyl carboxylase and a decrease in the carboxylation of prothrombin precursor, thereby causing a large amount of DCP to be produced and secreted into the blood circulation [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

The Value of MRI Combined with AFP, AFP-L3, GP73, and DCP in the Diagnosis of Early Primary Liver Cancer

Kang¹,

Jin

Jing

2022

Disease Markers

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Objective. To investigate the diagnostic value of magnetic resonance imaging (MRI) combined with serum alpha-fetoprotein (AFP), alpha-fetoprotein (AFP-L3), Golgi protein 73 (GP73), and des-γ-carboxyprothrombin (DCP) on early-stage primary liver cancer (PHC). Methods. A total of 122 patients who were treated in our hospital from January 2019 to May 2022 were included in this study, including 62 patients with early PHC (referred to as the observation group) and 60 patients with benign liver disease (referred to as the control group). MRI scans were performed on all participants, and MRI image features were compared. Subsequently, the differences in serum AFP, AFP-L3, GP73, and DCP concentrations of the two groups of patients were detected and compared. Receiver operating characteristic (ROC) curve was used to analyze the efficacy of MRI and each of the above tumor markers in diagnosing early PHC. Results. The proportion of low or slightly low signal on T1WI in the observation group was significantly greater than that in the control group, while the proportions of equisignal and high signal were lower than those in the control group. The proportion of high signal on T2WI and high signal on DWI in the observation group was higher than that in the control group, while the proportion of low or slightly low signal and equisignal was lower than that in the control group. Compared with the control group, the serum concentrations of AFP, AFP-L3, GP73, and DCP in the observation group were significantly increased (all P < 0.05 ). For the diagnosis of early-stage PHC patients, MRI combined with these four markers showed favorable diagnostic value compared with parameter alone (area under the ROC curve, sensitivity, and specificity were 0.943, 0.919, and 0.833, respectively). Conclusion. MRI combined with serum AFP, AFP-L3, GP73, and DCP detection has good value in the diagnosis of early PHC patients, and can serve as an effective strategy to improve the early diagnosis rate of PHC.

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Section: Discussionmentioning

confidence: 99%

The Value of MRI Combined with AFP, AFP-L3, GP73, and DCP in the Diagnosis of Early Primary Liver Cancer

Kang¹,

Jin

Jing

2022

Disease Markers

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“…Its function is incompletely understood. Golgi protein 73 expression is linked to patients with liver disease, particularly HCC ( 184 , 185 ). In the serum of HCC patients, Golgi protein 73 concentration is significantly elevated compared to patients with liver cirrhosis ( 186 ).…”

Section: Promising New Biomarkers For Clinical Applicationmentioning

confidence: 99%

HCC biomarkers – state of the old and outlook to future promising biomarkers and their potential in everyday clinical practice

et al. 2022

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Hepatocellular carcinoma (HCC) is one of the most common and deadly tumors worldwide. Management of HCC depends on reliable biomarkers for screening, diagnosis, and monitoring of the disease, as well as predicting response towards therapy and safety. To date, imaging has been the established standard technique in the diagnosis and follow-up of HCC. However, imaging techniques have their limitations, especially in the early detection of HCC. Therefore, there is an urgent need for reliable, non/minimal invasive biomarkers. To date, alpha-fetoprotein (AFP) is the only serum biomarker used in clinical practice for the management of HCC. However, AFP is of relatively rather low quality in terms of specificity and sensitivity. Liquid biopsies as a source for biomarkers have become the focus of clinical research. Our review highlights alternative biomarkers derived from liquid biopsies, including circulating tumor cells, proteins, circulating nucleic acids, and exosomes, and their potential for clinical application. Using defined combinations of different biomarkers will open new perspectives for diagnosing, treating, and monitoring HCC.

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“…In fact, it has been observed that hyperglycemia persists for 3 years after recovery from SARS(Yang et al, 2010). Apart from the role of GP73 in promoting cell proliferation, tumor development, and metastasis(Wang and Wan, 2020), GP73 also represses the host innate immune response to promote RNA virus replication(Zhang et al, 2017). Therefore, long-term follow-up of infected patients is a priority.…”

Section: Discussionmentioning

confidence: 99%

GP73 is a glucogenic hormone regulating SARS-CoV-2-induced hyperglycemia

Wan¹,

Yang²,

Li³

et al. 2021

Preprint

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces new-onset diabetes and severe metabolic complications of pre-existing diabetes. The pathogenic mechanism underlying this is incompletely understood. Here, we provided evidence linking circulating GP73 with the exaggerated gluconeogenesis triggered by SARS-CoV-2 infection. We found that SARS-CoV-2 infection or glucotoxic condition increased the cellular secretion of GP73. Secreted GP73 trafficked to the liver and kidney to stimulate gluconeogenesis through cAMP/PKA pathway. By using global phosphoproteomics, we found a drastic remodeling of PKA kinase hub exerted by GP73. Notably, COVID-19 patients showed pathologically elevated plasma GP73, and neutralization of the secreted GP73 inhibited enhanced PKA signaling and glucose production associated with SARS-CoV-2 infection. GP73 blockade also reduced gluconeogenesis and lowered hyperglycemia in type 2 (T2D) diabetic mice. Therefore, our findings provide novel insight into the roles of GP73 as a key glucogenic hormone and mechanistic clues underlying the development of SARS-CoV-induced glucose abnormalities.

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Golgi protein 73, hepatocellular carcinoma and other types of cancers

Cited by 19 publications

References 82 publications

The Value of MRI Combined with AFP, AFP-L3, GP73, and DCP in the Diagnosis of Early Primary Liver Cancer

The Value of MRI Combined with AFP, AFP-L3, GP73, and DCP in the Diagnosis of Early Primary Liver Cancer

HCC biomarkers – state of the old and outlook to future promising biomarkers and their potential in everyday clinical practice

GP73 is a glucogenic hormone regulating SARS-CoV-2-induced hyperglycemia

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