Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion

Jin, Dayong; Tao, Jun; Li, Dan; Wang, Yanan; Li, Li; Hu, Zhongdong; Zhou, Zhen; Chang, Xiuli; Qu, Chunfeng; Zhang, Hongbing

doi:10.18632/oncotarget.5590

Cited by 45 publications

(39 citation statements)

References 31 publications

(31 reference statements)

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“…However, the mechanism by which GP73 promotes tumor progression remains unclear. Recently, a study demonstrated that GP73 potentiated HCC cell invasion by upregulating matrix metalloproteinase-13 (29), supporting the role of GP73 in HCC as suggested by the present study. In summary, the present study demonstrated that sGP73 was not a diagnostic marker but rather a prognostic factor for HCC.…”

Section: Discussionsupporting

confidence: 90%

Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma

Dong

Chen

et al. 2017

Oncol Lett

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Abstract. Serum Golgi protein 73 (sGP73) is a candidate diagnostic biomarker for hepatocellular carcinoma (HCC). However, current evidence of its diagnostic value is conflicting, primarily due to the small sample sizes of previous studies, and its prognostic role in HCC also remains unclear. In the present study, sGP73 levels in 462 patients with HCC, 186 patients with liver cirrhosis, and 83 healthy controls were evaluated using ELISA, and it was identified that the median sGP73 levels were significantly higher in the HCC (18.7 ng/ml) and liver cirrhosis (18.5 ng/ml) patients than in the healthy controls (0 ng/ml; both P<0.001); however, the levels did not significantly differ between the HCC and liver cirrhosis groups (P=0.632). sGP73 had an inferior sensitivity and specificity for HCC diagnosis (27.79 and 77.96%, respectively) compared with α-fetoprotein (57.36 and 90.96%, respectively; P<0.001). In the HCC group, a high level of sGP73 was associated with aggressive clinicopathological features and independently predicted poor overall survival (OS) time (P<0.001). Additionally, in patients with resectable HCC, a high level of sGP73 was associated with significantly decreased disease-free survival (P<0.001) and OS (P=0.039) times compared with a low level of sGP73. This study demonstrated that sGP73 is unsuitable as a diagnostic marker for the early detection of HCC; however, it is an independent negative prognostic marker, providing a novel risk stratification factor and a potential therapeutic molecular target for HCC.

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Section: Discussionsupporting

confidence: 90%

Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma

Dong

Chen

et al. 2017

Oncol Lett

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“…Currently, the knowledge on the function of GOLM1 is limited. It was reported that GOLM1 acts as a key oncogene by promoting tumor cell invasion, migration, growth, and metastasis in hepatocellular carcinoma and oesophageal cancer . GOLM1 augments hepatocellular carcinoma invasion through activation of the CREB‐MMP‐13 signaling pathway .…”

Section: Introductionmentioning

confidence: 99%

GOLM1 promotes prostate cancer progression through activating PI3K‐AKT‐mTOR signaling

Yan

et al. 2017

The Prostate

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“…Jin et al reported that GOLPH2 promotes HCC invasion by activation of matrix metalloproteinase-13 (MMP-13) [32]. MMP-13 has a documented role in melanoma.…”

Section: Discussionmentioning

confidence: 99%

Golgi-Related Proteins GOLPH2 (GP73/GOLM1) and GOLPH3 (GOPP1/MIDAS) in Cutaneous Melanoma: Patterns of Expression and Prognostic Significance

Donizy

Kaczorowski

Biecek

et al. 2016

IJMS

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GOLPH2 and GOLPH3 are Golgi-related proteins associated with aggressiveness and progression of a number of cancers. Their prognostic significance in melanoma has not yet been analyzed. We performed immunohistochemical analysis for GOLPH2 and GOLPH3 in 20 normal skin, 30 benign nevi and 100 primary melanoma tissue samples and evaluated their expression in three compartments: cancer cells, tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs). High levels of both proteins in melanoma cells were associated with characteristics of aggressive disease, and shorter disease-free survival (DFS) and cancer-specific overall survival (CSOS). On the contrary, increased numbers of GOLPH2-positive and GOLPH3-positive TAMs were observed in thinner, non-ulcerated tumors, with brisk lymphocytic reaction and absent lymphangioinvasion. Distant metastases were not observed among patients with high numbers of GOLPH2-positive TAMs. Increased expression of either protein in TAMs was related to prolonged CSOS and DFS. Similarly, GOLPH3-expressing CAFs were more frequent in thin melanomas with low mitotic rate, without ulceration and lymphangioinvasion. Moreover, increased GOLPH3-positive CAFs correlated with the absence of regional or distant metastases, and with longer CSOS and DFS. GOLPH2 expression was not observed in CAFs. Our results suggest that GOLPH2 and GOLPH3 play a role in melanoma progression and are potential targets for molecular-based therapies.

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Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion

Cited by 45 publications

References 31 publications

Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma

Serum Golgi protein 73 is a prognostic rather than diagnostic marker in hepatocellular carcinoma

GOLM1 promotes prostate cancer progression through activating PI3K‐AKT‐mTOR signaling

Golgi-Related Proteins GOLPH2 (GP73/GOLM1) and GOLPH3 (GOPP1/MIDAS) in Cutaneous Melanoma: Patterns of Expression and Prognostic Significance

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