Goldfish (Carassius auratus L.) as a model system to study the growth factors, receptors and transcription factors that govern myelopoiesis in fish

Katzenback, Barbara A.; Katakura, Fumihiko; Belosevic, Miodrag

doi:10.1016/j.dci.2015.10.024

Cited by 20 publications

(16 citation statements)

References 220 publications

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“…However, it cannot be used in non-model organism research. In goldfish, model systems have been established to measure myelopoiesis34, granulopoiesis35, erythropoiesis1516, and thrombopoiesis36. In vivo transplantation to test the repopulation activity of donor cells has been the gold standard for the characterisation of HSPCs.…”

Section: Discussionmentioning

confidence: 99%

Mobilisation and dysfunction of haematopoietic stem/progenitor cells after Listonella anguillarum infection in ayu, Plecoglossus altivelis

Chen

Rong

et al. 2016

Sci Rep

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Haematopoietic stem/progenitor cells (HSPCs) can mobilise into blood and produce immune cell lineages following stress. However, the homeostasis and function of HSPCs after infection in teleosts are less well known. Here, we report that Listonella anguillarum infection enhances HSPC mobilisation and reduces their differentiation into myeloid cells in ayu (Plecoglossus altivelis), an aquacultured teleost in East Asia. We established a colony-forming unit culture (CFU-C) assay to measure HSPCs using conditioned medium from peripheral blood mononuclear cells stimulated with phytohaemagglutinin. The number of CFU-Cs decreased in the head kidney and increased in the blood and spleen of ayu infected with L. anguillarum. HSPC mobilisation after L. anguillarum infection was mediated by norepinephrine. Furthermore, HSPCs from ayu treated with L. anguillarum lipopolysaccharide (LPS) showed defective myeloid differentiation and could no longer rescue L. anguillarum-infected ayu. HSPC expansion was suppressed after L. anguillarum infection or its LPS treatment in vitro. These results reveal a link between HSPC regulation and pathogen infection in teleosts.

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Section: Discussionmentioning

confidence: 99%

Mobilisation and dysfunction of haematopoietic stem/progenitor cells after Listonella anguillarum infection in ayu, Plecoglossus altivelis

Chen

Rong

et al. 2016

Sci Rep

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“…Zebrafish raised at cooler temperatures (17°C versus 26.5°C) for up to 7 months display a selective decrease in erythrocytes, but not myeloid cells, resulting in an anemic state [ 49 ]. Examination of the gene expression of key growth factors involved in hematopoiesis revealed a decrease in the expression of erythropoietin ( epo ) and erythropoietin receptor ( epor) in kidney marrow, important for erythropoiesis [ 50 , 51 , 52 ], but not in colony-stimulating factor-1a ( csf1a) or csf3 expressions that are important for generation of macrophages and granulocytes, respectively [ 49 , 53 , 54 , 55 ]. These studies suggest that while macrophages and granulocytes (neutrophils) are still produced at normal levels, the expressions of key proinflammatory cytokines and proteins involved in viral recognition may be suppressed or delayed, at least at the transcript level, under hypothermic levels during fish ontogeny.…”

Section: Innate Immunity and Temperaturementioning

confidence: 99%

Impacts of Low Temperature on the Teleost Immune System

Abram

Dixon

Katzenback

2017

Biology

132

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As poikilothermic vertebrates, fish can experience changes in water temperature, and hence body temperature, as a result of seasonal changes, migration, or efflux of large quantities of effluent into a body of water. Temperature shifts outside of the optimal temperature range for an individual fish species can have negative impacts on the physiology of the animal, including the immune system. As a result, acute or chronic exposure to suboptimal temperatures can impair an organisms’ ability to defend against pathogens and thus compromise the overall health of the animal. This review focuses on the advances made towards understanding the impacts of suboptimal temperature on the soluble and cellular mediators of the innate and adaptive immune systems of fishes. Although cold stress can result in varying effects in different fish species, acute and chronic suboptimal temperature exposure generally yield suppressive effects, particularly on adaptive immunity. Knowledge of the effects of environmental temperature on fish species is critical for both the optimal management of wild species and the best management practices for aquaculture species.

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“…It should also be added that in invertebrates, the cells that are functionally similar to vertebrate (but not mammalian) thrombocytes and to mammalian platelets are the nucleated haemocytes circulating in haemolymph, also called immunocytes (4). Thrombocytes in Osteichthyes have a nucleus and, functionally, they are cells corresponding to platelets in mammals but, with regard to the origin of these cells, it should be underlined that megakaryocytes from which mammalian platelets develop are absent in Osteichthyes (11, 13, 14). Thrombocytes develop in the head kidney ( pronephros ), an analogue of bone marrow in mammals (14), as myeloid cells in the process of thrombopoiesis and as part of myelopoiesis, just like monocytes/macrophages (monopoiesis), granulocytes (granulopoiesis) or erythrocytes (erythropoiesis) do.…”

Section: Introductionmentioning

confidence: 99%

“…Thrombocytes in Osteichthyes have a nucleus and, functionally, they are cells corresponding to platelets in mammals but, with regard to the origin of these cells, it should be underlined that megakaryocytes from which mammalian platelets develop are absent in Osteichthyes (11, 13, 14). Thrombocytes develop in the head kidney ( pronephros ), an analogue of bone marrow in mammals (14), as myeloid cells in the process of thrombopoiesis and as part of myelopoiesis, just like monocytes/macrophages (monopoiesis), granulocytes (granulopoiesis) or erythrocytes (erythropoiesis) do. The precursor or parent cells for the cells mentioned above and for lymphoid cells are haematopoietic stem cells (HSCs) and haematopoietic progenitor cells (HPCs) (14).…”

Section: Introductionmentioning

confidence: 99%

Characterisation of thrombocytes in Osteichthyes

Stosik

Tokarz–Deptuła²,

Deptuła

2019

Journal of Veterinary Research

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Thrombocytes in vertebrates other than mammals, inter alia in fish, are analogues of platelets in mammals. In Osteichthyes, these cells take part in haemostatic processes, including aggregation and release reactions in cases of blood vessel damage, and in the immune response development as well. This paper discusses the development of thrombocytes in Osteichthyes, taking into account the need to make changes to the concept of grouping progenitor cells as suggested in the literature. The following pages present the morphological and cytochemical properties of thrombocytes as well as their defence functions, and also point out differences between thrombocytes in fish and platelets in mammals. The paper further highlights the level of thrombocytes’ immune activity observed in fish and based on an increased proportion of these cells in response to antigenic stimulation, on morphological shifts towards forms characteristic of dendritic cells after antigenic stimulation and on the presence of surface structures and cytokines released through, inter alia, gene expression of TLR receptors, MHC class II protein-coding genes and pro-inflammatory cytokines. The study also points out the need to recognise thrombocytes in Osteichthyes as specialised immune cells conditioning non-specific immune mechanisms and playing an important role in affecting adaptive immune mechanisms.

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Goldfish (Carassius auratus L.) as a model system to study the growth factors, receptors and transcription factors that govern myelopoiesis in fish

Cited by 20 publications

References 220 publications

Mobilisation and dysfunction of haematopoietic stem/progenitor cells after Listonella anguillarum infection in ayu, Plecoglossus altivelis

Mobilisation and dysfunction of haematopoietic stem/progenitor cells after Listonella anguillarum infection in ayu, Plecoglossus altivelis

Impacts of Low Temperature on the Teleost Immune System

Characterisation of thrombocytes in Osteichthyes

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