Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues

Mandal, Sudip Kumar; Maji, Amal K.; Mishra, Siddhartha; Ishfaq, Pir Mohammad; Devkota, Hari Prasad; Sanches-Silva, A.; Das, Niranjan

doi:10.1016/j.phrs.2020.105085

Cited by 29 publications

(13 citation statements)

References 207 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The main active constituent of H. canadensis (Goldenseal) is berberine, which has antidiarrheal activity. It contains cardiac glycosides, sugar, amino acids, balsams, resins, terpenes, saponins, anthroquinone, flavonoids, tannins, steroids, phlobatannins, phenolics, anthocyanosides, and alkaloids (reviewed by Mandal et al, 2020). It is used for the treatment of ringworm, scabies, itches, skin diseases, abscess, throat infection, itch, wounds, pyrexia, bone fracture, rheumatism, hematuria, diabetes mellitus, leprosy, hemoglobin disorders, asthma, tuberculosis, typhoid fever, liver disorders, inflammation, edema, constipation, scorpion bite, snake bite, hepatitis and, asthma.…”

Section: Methodsmentioning

confidence: 99%

“…It is an immunosuppressant, hepatoprotective, antioxidant, antiinflammatory, antimalarial, antifungal, and antibacterial. Few studies have also suggested the possible neurotoxic, hepatotoxic, and phototoxic activities of goldenseal extract and its alkaloids (reviewed by Mandal et al, 2020). It is contraindicated in pregnancy and in lactating mothers due to its uterine‐stimulant effects (Ernst, 2002; O'Hara et al, 1998).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Is it safe to consume traditional medicinal plants during pregnancy?

Bernstein

Akram

Yaniv-Bachrach

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

The popularity of natural medicine is growing worldwide. Unlike conventional licensed medicines, herbal medicine practices are usually not supported by effectiveness, efficacy, or safety studies, which raise concerns about potential risks involved in their usage, particularly in high‐risk patients such as pregnant women where teratogenicity is a concern. Despite a lack of science‐based evidence, the use of herbal products for the management of pregnancy‐associated challenges is common, due to the common notion that they are free of toxic effects and adverse reactions because they are “natural.” The lack of concern about utilizing herbal remedies during pregnancy is strengthened by the lack of regulation in most countries for their marketing. However, plant‐based remedies are not free of adverse reactions. Medicinal plants and herbal remedies contain substances that can be toxic to the human body and the fetus. Potential effects of indiscriminate use of medicinal plants are embryotoxicity, teratogenic, and abortifacient effects. Some plant constituents can cross the placenta and reach the fetus. Phytochemicals and their metabolites are known to induce stimulation of uterine contraction and hormone imbalance that could result in abortion. The alterations to the hormonal profile can affect conception, induce teratogenic activity, and halt the pregnancy or produce a congenital malformation. Due to the wide range of modes of action of phytochemicals, some medicinal plants may be safe to use during certain trimesters of pregnancy and harmful at other stages. This manuscript reviews available scientific information concerning potential health hazards associated with the consumption of herbal medicines during pregnancy, highlighting those herbs that should be avoided due to their potential abortifacient and/or teratogenic activity. We focused on plants that were tested by preclinical studies, and studies of these plants are summarized. Common therapeutic use of these herbs, estimated effects, toxicological effects, and animal studies of these plants is summarized. The literature reviewed suggests that consumption of the following medicinal plants should be avoided during pregnancy: Abrus precatorius, Achyranthes aspera, Ailanthus excelsa, Aloe vera, Aristolochia indica, Areca catechu, Bambusa vulgaris, Cassia occidentalis, Cicer arietinum, Cimicifuga racemose, Dolichandrone falcate, Ginkgo biloba, Hydrastis canadensis, Indigofera trifoliate, Lavandula latifolia, Maytenus ilicifolia, Momordica cymbalaria, Moringa oleifera, Musa rosacea, Oxalis corniculate, Phytolacca dodecandra, Plumeria rubra, Ricinus communis, Ruta graveolens, Stachys lavandulifolia, Senna alata, Trigonella foenum‐graecum, Vitus agnus‐castus, and Valeriana officinalis.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Is it safe to consume traditional medicinal plants during pregnancy?

Bernstein

Akram

Yaniv-Bachrach

et al. 2020

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Several in vivo and in vitro studies confirmed that the extracts of Hydrastis canadensis (Goldenseal) have antibacterial activity towards Gram-positive UPs, including methicillinresistant Staphylococcus aureus, due to alkaloid compounds such as berberine, hydrastine, and canadine, which has antibacterial activity against Gram-positive pathogens (Mandal et al, 2020;Sadeq Abdulridha et al, 2020). Otherwise, other plant extracts like rosemary (Rosmarinus officinalis) have been found to be effective against UPs such as E. coli, P. mirabilis, Prunella vulgaris, K. pneumoniae, P. aeruginosa, and S. aureus (Sadeq Abdulridha et al, 2020).…”

Section: Juss Neemmentioning

confidence: 96%

Urinary tract infections: Virulence factors, resistance to antibiotics, and management of uropathogenic bacteria with medicinal plants—A review

Arsène¹,

Podoprigora²,

Davares³

et al. 2020

J Appl Pharm Sci

View full text Add to dashboard Cite

Urinary tract infections (UTIs) are among the most common infections in most countries and they are usually caused by the so-called uropathogenic (UP) microorganisms, including Escherichia coli (80%-90%), Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Proteus mirabilis, and Klebsiella pneumoniae. Over the years, the growth of resistance to antibiotics has complicated the treatment of UTIs and has direct consequences on the cost of treatment, the severity of infections, and the length of hospitalization. Medicinal plants, used for thousands of years to treat various diseases, constitute a serious alternative to antibiotics in the public health issue of antimicrobial resistance. In this review, the in vitro and in vivo use of medicinal plants and their nanoparticles (silver, gold, zinc, copper oxide, magnesium oxide, iron, etc.) in the management of uropathogens and their virulence factors (VFs) as well as in the management of UTIs themselves have been discussed. Given the advantages offered by the biologically active compounds of medicinal plants as well as their green-synthetized nanoparticles whether used as such or in combination with conventional antibiotics, it can be concluded that herbal medicine can significantly help in the management of UTIs.

show abstract

“…Goldenseal ( Hydrastis canadensis ) is a herbaceous plant, native to North America [ 68 ]. It is traditionally used for the management of a variety of conditions including cancer [ 68 ].…”

Section: Clinically Significant Pharmacokinetic Interactionsmentioning

confidence: 99%

Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance

Chan

Adiwidjaja

McLachlan

et al. 2023

Cancer Chemother Pharmacol

View full text Add to dashboard Cite

Natural products, also referred to as dietary supplements, complementary and alternative medicines, and health or food supplements are widely used by people living with cancer. These products are predominantly self-selected and taken concurrently with cancer treatments with the intention of improving quality of life, immune function and reducing cancer symptoms and treatment side effects. Concerns have been raised that concurrent use may lead to interactions resulting in adverse effects and unintended treatment outcomes. This review provides an overview of the mechanisms by which these interactions can occur and the current evidence about specific clinically important natural product–drug interactions. Clinical studies investigating pharmacokinetic interactions provide evidence that negative treatment outcomes may occur when Hypericum perforatum, Grapefruit, Schisandra sphenanthera, Curcuma longa or Hydrastis canadensis are taken concurrently with common cancer treatments. Conversely, pharmacodynamic interactions between Hangeshashinto (TJ-14) and some cancer treatments have been shown to reduce the side effects of diarrhoea and oral mucositis. In summary, research in this area is limited and requires further investigation.

show abstract

Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues

Cited by 29 publications

References 207 publications

Is it safe to consume traditional medicinal plants during pregnancy?

Is it safe to consume traditional medicinal plants during pregnancy?

Urinary tract infections: Virulence factors, resistance to antibiotics, and management of uropathogenic bacteria with medicinal plants—A review

Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance

Contact Info

Product

Resources

About