Golden Ager Chyawanprash with Meager Evidential Base from Human Clinical Trials

Sharma, Rohit; Kakodkar, Pradnya; Kabra, Atul; Prajapati, Pradeep Kumar

doi:10.1155/2022/9106415

Cited by 9 publications

(5 citation statements)

References 27 publications

(27 reference statements)

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“…But in the aftermath, a neurotrauma astroglial scar border develops, identifying and segregating all sites of the focused lesion from the brain, which is sound. Prevention during astrogliosis, resulting in a distorted astroglial defect, worsens cellular injury and the neurologic deficiency [156][157][158][159][160][161].…”

Section: Glial Cells' Importance In Neurological Disordersmentioning

confidence: 99%

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Rahman

Islam

Yamin

et al. 2022

Oxidative Medicine and Cellular Longevity

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Based on the diverse physiological influence, the impact of glial cells has become much more evident on neurological illnesses, resulting in the origins of many diseases appearing to be more convoluted than previously happened. Since neurological disorders are often random and unknown, hence the construction of animal models is difficult to build, representing a small fraction of people with a gene mutation. As a result, an immediate necessity is grown to work within in vitro techniques for examining these illnesses. As the scientific community recognizes cell-autonomous contributions to a variety of central nervous system illnesses, therapeutic techniques involving stem cells for treating neurological diseases are gaining traction. The use of stem cells derived from a variety of sources is increasingly being used to replace both neuronal and glial tissue. The brain’s energy demands necessitate the reliance of neurons on glial cells in order for it to function properly. Furthermore, glial cells have diverse functions in terms of regulating their own metabolic activities, as well as collaborating with neurons via secreted signaling or guidance molecules, forming a complex network of neuron-glial connections in health and sickness. Emerging data reveals that metabolic changes in glial cells can cause morphological and functional changes in conjunction with neuronal dysfunction under disease situations, highlighting the importance of neuron-glia interactions in the pathophysiology of neurological illnesses. In this context, it is required to improve our understanding of disease mechanisms and create potential novel therapeutics. According to research, synaptic malfunction is one of the features of various mental diseases, and glial cells are acting as key ingredients not only in synapse formation, growth, and plasticity but also in neuroinflammation and synaptic homeostasis which creates critical physiological capacity in the focused sensory system. The goal of this review article is to elaborate state-of-the-art information on a few glial cell types situated in the central nervous system (CNS) and highlight their role in the onset and progression of neurological disorders.

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Section: Glial Cells' Importance In Neurological Disordersmentioning

confidence: 99%

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Rahman

Islam

Yamin

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Neuroprotection is a treatment method that modifies the consequences of the ischemia cascade or facilitates reperfusion in order to protect neurons from suffering irreparable damage. This is done in the hopes of preventing neuronal death [165]. Despite the fact that various medicines have shown neuroprotective effects in preclinical studies, the translation of those findings to clinical trials has failed to show any significant impact.…”

Section: Neuroprotection: Challenges and Opportunitiesmentioning

confidence: 99%

Perspectives on the Molecular Mediators of Oxidative Stress and Antioxidant Strategies in the Context of Neuroprotection and Neurolongevity: An Extensive Review

Shohag

Akhter

Islam

et al. 2022

Oxidative Medicine and Cellular Longevity

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Molecules with at least one unpaired electron in their outermost shell are known as free radicals. Free radical molecules are produced either within our bodies or by external sources such as ozone, cigarette smoking, X-rays, industrial chemicals, and air pollution. Disruption of normal cellular homeostasis by redox signaling may result in cardiovascular, neurodegenerative diseases and cancer. Although ROS (reactive oxygen species) are formed in the GI tract, little is known about how they contribute to pathophysiology and disease etiology. When reactive oxygen species and antioxidants are in imbalance in our bodies, they can cause cell structure damage, neurodegenerative diseases, diabetes, hypercholesterolemia, atherosclerosis, cancer, cardiovascular diseases, metabolic disorders, and other obesity-related disorders, as well as protein misfolding, mitochondrial dysfunction, glial cell activation, and subsequent cellular apoptosis. Neuron cells are gradually destroyed in neurodegenerative diseases. The production of inappropriately aggregated proteins is strongly linked to oxidative stress. This review’s goal is to provide as much information as possible about the numerous neurodegenerative illnesses linked to oxidative stress. The possibilities of multimodal and neuroprotective therapy in human illness, using already accessible medications and demonstrating neuroprotective promise in animal models, are highlighted. Neuroprotection and neurolongevity may improve from the use of bioactive substances from medicinal herbs like Allium stadium, Celastrus paniculatus, and Centella asiatica. Many neuroprotective drugs’ possible role has been addressed. Preventing neuroinflammation has been demonstrated in several animal models.

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“…So overall it can be said that though PD have many treatments but they have also some drawbacks that’s why these treatments are not so ideal. Further research is warranted to explore several folklore or traditional medicinal herbs and their myriad of bioactive phytochemicals to develop new safe and effective anti PD drug agents ( Sharma et al, 2022a ; Sharma et al, 2022b ; Sharma et al, 2022c ).…”

Section: Challenges With Current Synthesismentioning

confidence: 99%

Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance

Rahman

Wang²,

Islam³

et al. 2022

Front. Pharmacol.

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Natural substances originating from plants have long been used to treat neurodegenerative disorders (NDs). Parkinson’s disease (PD) is a ND. The deterioration and subsequent cognitive impairments of the midbrain nigral dopaminergic neurons distinguish by this characteristic. Various pathogenic mechanisms and critical components have been reported, despite the fact that the origin is unknown, such as protein aggregation, iron buildup, mitochondrial dysfunction, neuroinflammation and oxidative stress. Anti-Parkinson drugs like dopamine (DA) agonists, levodopa, carbidopa, monoamine oxidase type B inhibitors and anticholinergics are used to replace DA in the current treatment model. Surgery is advised in cases where drug therapy is ineffective. Unfortunately, the current conventional treatments for PD have a number of harmful side effects and are expensive. As a result, new therapeutic strategies that control the mechanisms that contribute to neuronal death and dysfunction must be addressed. Natural resources have long been a useful source of possible treatments. PD can be treated with a variety of natural therapies made from medicinal herbs, fruits, and vegetables. In addition to their well-known anti-oxidative and anti-inflammatory capabilities, these natural products also play inhibitory roles in iron buildup, protein misfolding, the maintenance of proteasomal breakdown, mitochondrial homeostasis, and other neuroprotective processes. The goal of this research is to systematically characterize the currently available medications for Parkinson’s and their therapeutic effects, which target diverse pathways. Overall, this analysis looks at the kinds of natural things that could be used in the future to treat PD in new ways or as supplements to existing treatments. We looked at the medicinal plants that can be used to treat PD. The use of natural remedies, especially those derived from plants, to treat PD has been on the rise. This article examines the fundamental characteristics of medicinal plants and the bioactive substances found in them that may be utilized to treat PD.

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Golden Ager Chyawanprash with Meager Evidential Base from Human Clinical Trials

Cited by 9 publications

References 27 publications

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Emerging Role of Neuron-Glia in Neurological Disorders: At a Glance

Perspectives on the Molecular Mediators of Oxidative Stress and Antioxidant Strategies in the Context of Neuroprotection and Neurolongevity: An Extensive Review

Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance

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