Gold‐Zinc Co‐Catalyzed Alkynoate Hydrocarboxylation with N‐Protected Amino Acids for Preparation of Storable Acylating Reagents and Racemization‐Free Peptide Synthesis
Ayaka Sakurada,
Miyu Sato,
Kosuke Higashida
et al.
Abstract:Hydrocarboxylation of methyl 2‐octynoate, a chemical commercially available at a low cost, with <i>N</i>‐protected amino acids was developed with a gold‐zinc cooperative catalyst constructed with a 5‐[(2,2'‐bipyridin)‐5‐yl]imidazo[1,5‐<i>a</i>]pyridin‐3‐ylidene to prepare α‐methoxycarbonyl enol esters as acylating reagents. The α‐methoxycarbonyl enol esters were isolable through silica‐gel column chromatography and storable without precautions regarding moisture. Acylation of free amin… Show more
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