Gold thioglucose induction of obesity: significance of focal gold deposits in hypothalamus

Debons, AF; Krimsky, I.; From, Annette; Cloutier, RJ

doi:10.1152/ajplegacy.1970.219.5.1403

Cited by 20 publications

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“…Both GTG and MSG have been shown to produce lesions in the hypothala mus, and it is assumed that these lesions result in the development of obesity (Olney, 1969;Debons et al, 1970). The results of this study therefore suggest that hypothalamic obesity is primarily due to a decreased energy expenditure, i.e.…”

Section: Discussionmentioning

confidence: 63%

“…GTG and MSG have been used to produce obesity in adult and neonatal animals, respectively (Debons et at., 1970;Olney, 1969). In this study, experiments were conducted to determine the most suitable dose of GTG and MSG, which would induce obesity in female weanling mice (Ash-XP strain, Scientific Products Farm, Menton Research Centre, Margate, Kent).…”

Section: Dose Determinationsmentioning

confidence: 99%

“…This dose (which happens to be the LDS0), is therefore the best dose, inducing obesity in 290/1,000 of animals injected (620/1,000 of the injected mice survived). Previous workers have used higher doses of 0.8-1 mg/g in adult mice (Owan et at., 1953\Debons e ta l, 1968, 1970. …”

Section: Dose Determinationsmentioning

confidence: 99%

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Energy Balances in Obese Mice

Djazayery¹,

Miller²,

Stock³

1979

Ann Nutr Metab

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According to most existing theories, the regulation of energy balance is achieved by control of energy intake. This study was undertaken to find out whether there was control of energy output as well. Food intake, energy balance and the feed efficiency of weanling female mice made obese with injections of gold-thioglucose and monosodium glutamate indicate that the obesity is primarily due to an increased energetic efficiency, and suggest that the hypothalamus plays a role in controlling energy output. In the case of treatment with MSG, a relative obesity was observed, i.e. an increase in body fat without any change in body weight. This indicates that the CNS centres for the regulation of body weight and body fat are probably not the same. It is suggested that MSG obesity will be a suitable model for comparative studies of body weight and the regulation of fat content. It is concluded that chemically induced obesity is due more to a lower metabolic rate than to an elevated food intake.

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Section: Discussionmentioning

confidence: 63%

Section: Dose Determinationsmentioning

confidence: 99%

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Energy Balances in Obese Mice

Djazayery¹,

Miller²,

Stock³

1979

Ann Nutr Metab

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Tierexperimentelle Erzeugung von Fettsucht

Voss

Hartmann

Hübner

1972

Nahrung

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Es werden folgende Möglichkeiten zur tierexperimentellen Erzeugung von Fettsucht bei Versuchstieren beschrieben: Fettsucht durch Fettdiät, Hyperphagie durch Insulin, Periactinol, cerebrale ventrikuläre Infusion von Phlorrhizin oder Injektion von 4‐Nitrochinolin‐1‐oxid, Goldthioglucose, Bipiperidyl Senf, mechanische Schädigung des Hypothalamus sowie Verfettung nach ACTH sezernierenden Tumortransplantaten. Von diesen Fettsuchtformen dürfte die Erzeugung durch fetthaltiges Futter mit Rücksicht auf die gegenwärtig übliche Fehlernährung der Industriegesellschaft den meisten Fällen von Fettsucht beim Menschen am nächsten kommen. Daher sollten Vergleichsuntersuchungen zunächst an diesem Modell durchgeführt werden. Mit sehr viel geringerer Wahrscheinlichkeit dürften genetische Schäden, die ggfs. zentral durch Hyperphagie oder peripher durch Stoffwechselanomalie charakterisiert sind oder auch Intoxikationen mit besonderer Auswirkung auf den Hypothalamus zum Auftreten von Fettsuchtformen führen. Für diese Formen wären die genetischen Varianten und Goldthioglucose‐Tiere repräsentativ. Von besonderer Bedeutung ist aber auch die hormonale Regulation des Fettstoffwechsels mit ihren sehr differenzierten Auswirkungen auf verschiedene Körperpartien, z. B. Morbus Cushing. Für solche hormonale Dysregulation haben wir Vertreter in der ACTH‐Fettsucht und in der insulinbedingten Hyperphagie aufgewiesen. Für erste Untersuchungen dürften auch diese Modelle geeignet sein.

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Mechanisms of central control of the blood sugar

Amiragova¹,

Stul'nikov²

1975

Bull Exp Biol Med

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Gold thioglucose induction of obesity: significance of focal gold deposits in hypothalamus

Cited by 20 publications

References 0 publications

Energy Balances in Obese Mice

Energy Balances in Obese Mice

Tierexperimentelle Erzeugung von Fettsucht

Mechanisms of central control of the blood sugar

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