Gold Therapy in Rheumatoid Arthritis

Ellman, Philip; Js, Lawrence; Gp, Thorold

doi:10.1136/bmj.2.4157.314

Cited by 80 publications

(16 citation statements)

References 3 publications

(5 reference statements)

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“…Other workers have suggested an effect on tissue uptake of oxygen or on glutathione metabolism. Clinical experience with gold treatment would suggest that gold may have a general anti-inflammatory effect, STUDIES WITH RADIOACTIVE GOLD since it has a pronounced effect, when given in high dosage, on both the erythrocyte sedimentation rate and the degree of joint swelling (Ellman and Lawrence, 1938). Moreover, it is common experience that ulcers on the gums due to badly fitting dentures do not heal so rapidly in patients receiving gold.…”

Section: Discussionmentioning

confidence: 99%

Studies with Radioactive Gold

Lawrence¹

1961

Annals of the Rheumatic Diseases

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Section: Discussionmentioning

confidence: 99%

Studies with Radioactive Gold

Lawrence¹

1961

Annals of the Rheumatic Diseases

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“…Since knowledge of the potential risk of infection will inform the management of patients with RA-BR, a review of this literature is presented below. Hydroxychloroquine 49,50 , gold, 51 and corticosteroids 52,53 are the oldest non-biological DMARDs used in the treatment of RA. Newer agents include methotrexate (MTX), 54 sulfasalazine, 55 and leflunomide.…”

Section: Dmards and Infection Riskmentioning

confidence: 99%

Coexistence of Bronchiectasis and Rheumatoid Arthritis: Revisited

2013

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The presence of bronchiectasis (BR) in patients with rheumatoid arthritis (RA) has been recognized for many decades; nevertheless, little research has been undertaken in this area. It is important to recognize that BR coexistent with RA differs from the other types of BR. The purpose of this descriptive review was to delineate the epidemiology, etiology, risk factors, pulmonary function testing, imaging, prognosis and management of concomitant BR and RA. To inform our study we searched the PubMed, EMBASE, CINAHL, and MEDLINE databases, using combinations of the following key words: computed tomography, lung function tests, rheumatoid arthritis, bronchiectasis, biological agents, and interstitial lung disease. The number of published papers covering this topic is limited, but several relevant conclusions can be drawn. Patients with concomitant RA and BR have worse obstructive airways disease, increased susceptibility to recurrent pulmonary infections, faster lung function decline, and higher mortality, compared with subjects with either RA or BR alone. The use of disease-modifying anti-rheumatic drugs (both biological and non-biological) for RA in RA-BR patients imparts a further challenge in managing these patients. Although there are not any published guidelines on the management of coexisting RA-BR, we have attempted to provide such recommendations, based on the literature review and our experience.

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“…In the three controlled trials of gold therapy which have been carried out to date (Ellman et al, 1940;Fraser, 1945;Adams and Cecil, 1950) the cases receiving gold showed a greater degree of improvement than the control group, and this has been our own experience. Thus gold salts may well have some influence upon the rheumatoid disease process, but their mode of action remains obscure.…”

Section: Cortisone and Actilmentioning

confidence: 70%

Some Concepts of Rheumatic Disease.--II

Kellgren¹

1952

BMJ

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Gold Therapy in Rheumatoid Arthritis

Cited by 80 publications

References 3 publications

Studies with Radioactive Gold

Studies with Radioactive Gold

Coexistence of Bronchiectasis and Rheumatoid Arthritis: Revisited

Some Concepts of Rheumatic Disease.--II

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