Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kB signaling and Nrf2 pathway in high fat diet fed mice

Xu, Minxuan; Wang, Ming; Yang, Weiwei

doi:10.2147/ijn.s116010

Cited by 61 publications

(29 citation statements)

References 52 publications

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“…NF-κB, a primary regulator of inflammatory responses, plays a critical role in a variety of physiological and pathologic processes, and the NFkappa B signaling pathway is involved in both inflammation and oxidative stress and participates in the development of various metabolic diseases [34]. Recent studies have demonstrated that a highfat diet can affect peripheral tissues, and cause systematic inflammation by directly or indirectly activating the TLR4 and nuclear factor-kappa B NF-κB pathways [35,36]. Our transcription data obtained through KEGG pathway analysis indicated that the NF-kappa B signaling pathway was significantly inhibited by an EHF, and TLR4, the most pronounced hub gene according to both PPI and MDOCE analyses, was significantly downregulated in the EHF group.…”

Section: Discussionmentioning

confidence: 99%

A Calorically Restricted High-fat Diet Reverses High-fat Diet-induced Injurious Effects on Health and Gene Expression in Rats

Guan

et al. 2019

Preprint

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Background: A High-fat diet has been reported to produce excess lipid accumulation and increase inflammatory factors and oxidative stress in various metabolic diseases. Caloric restriction (CR) is one of the most valuable tools in reducing inflammation, enhancing anti-oxidative activity and ameliorating various metabolic diseases. However, excess CR may restrain growth, development and normal physiological processes. Our study was conducted to investigate the effects of a high-fat diet containing the same number of calories as a basic diet on the health and gene expression patterns of rats.Methods: 30 Wistar male rats were randomly devided into a normal control (NC) group, an equicaloric high-fat (EHF) group as the NC group, and a high-fat (HF) ad libitum group. Food consumption and body weight were recorded once a week. Blood biochemistical and genomic assessments of the liver were carried out after intervention for 20 weeks. Results: Compared with the NC group, serum triglycerides (TG), total cholesterol (TCHO), low-density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST) and andalanine aminotransferase (ALT) levels were significantly increased in the HF group, and the serum levels of interleukin- 6 (IL-6), reactive oxygen species (ROS) and glutathione (GSH) were significantly decreased in the HF group. Compared with the HF group, serum TG,TCHO,LDL-C, AST, ALT, IL-6, ROS levels were significantly decreased in the EHF group, and the serum levels of GSH and superoxide dismutase (SOD) were also significantly increased. Histological studies showed decreased macrovesicular steatosis, inflammatory cell infiltration and structural damagein EHF group compared to the HF group. In addition, transcription analysis revealed that an EHF led tochanges in gene expression, including a reduction inToll-like receptor 4 (TRL4),which inhibited NF-kappa B signaling pathway and upregulatedglutathione S-transterases (GSTs) to increase antiocidative activity.Conclusions: an EHF restored deleterious changes in the health and gene expression patterns induced by a high-fat diet ad libitum in rats via reduced inflammation and increased antioxidative activity.

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Section: Discussionmentioning

confidence: 99%

A Calorically Restricted High-fat Diet Reverses High-fat Diet-induced Injurious Effects on Health and Gene Expression in Rats

Guan

et al. 2019

Preprint

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“…based on this study, 2HF may serve as a promising drug for PCa therapy, which may not only inhibit androgen-AR signaling and induce PCa cell death, but also prevent cell migration and invasion during PCa metastasis. In addition, there are several nanodiamonds combined with plant compounds to improve their anticancer activity (28,29). The biotechnological application of nanomaterials associated with 2HF is another potential treatment strategy for PCa.…”

Section: Discussionmentioning

confidence: 99%

2'‑Hydroxyflavanone inhibits epithelial‑mesenchymal transition, and cell migration and invasion via suppression of the Wnt/β‑catenin signaling pathway in prostate cancer

Huang

Hui

et al. 2018

Oncol Rep

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Despite the availability of a number of treatment options, certain cases of primary prostate cancer (PCa) will develop into metastatic PCa, in which epithelial‑mesenchymal transition (EMT) serves an important role. Recently, a natural flavonoid known as 2'‑hydroxyflavanone (2HF) exerts remarkable anticancer activity on various types of cancer. Our previous study demonstrated that 2HF could promote apoptosis and inhibit the proliferation of PCa cells, but whether 2HF is involved in the regulation of EMT, and cell migration and invasion in metastatic PCa remains unknown. The present study used two different metastatic PCa cell lines (PC‑3 and DU145) to investigate the effects of 2HF on EMT, and cell migration and invasion. The results demonstrated that 2HF could inhibit EMT, and cell migration and invasion through the Wnt/β‑catenin signaling pathway by suppressing GSK‑3β phosphorylation, β‑catenin expression and transactivation. In conclusion, the present study revealed a novel function of 2HF, which may be used to prevent or treat PCa metastasis.

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“…GQ poly (d,l-lactide-co-glycolide)-loaded gold nanoparticles precipitated with quercetin (GQ) restore the metabolic disorders caused by high-fat diet, which suppresses insulin resistance, lipid metabolic imbalance, and proinflammatory cytokine production. These prevent kidney injury by inhibition of TLR4/NF-κB and oxidative stress, further increasing superoxide dismutase activity [6].…”

Section: Gold Nanoparticles (Gnps)mentioning

confidence: 99%

“…Nicotine, a major toxic component of cigarette smoke, is responsible for smoking-mediated renal dysfunction [5]. High-fat diet-induced metabolic syndromes followed by chronic kidney disease caused by intestinal endotoxemia have received extensive attention [6] (Table 2 and Figures 4 and 5). …”

Section: Introductionmentioning

confidence: 99%

Chronic Kidney Diseases and Nanoparticle Therapeutics

Upadhyay¹

2017

J Tissue Sci Eng

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Present review article describes main causes of chronic kidney disease a major health problem public health problem round the globe. Disease has multiple etiologies related to sequential pathophysiological stages. It has major concern with chronic changes in renal structure and that severely alter glomerular filtration rate in patients. This article explains CKD biomarkers in brief i.e., serum creatinine, periostin, a matricellular protein discoidin domain receptor 1 (DDR1), a transmembrane collagen receptor of the tyrosine kinase family, Phospholipase D4 (PLD4) renal biomarkers, metabolic biomarkers. The main focus was given on use of nanoparticles for CKD therapeutics. This article describes various metal and metal oxide nanaoparticles, such as cuprous oxide (CONPs), super paramagnetic iron oxide (new SPIO) nanoparticles, silica-coated iron oxide nanoparticle, Vanadium oxide nanoparticles (VONPs, Titanium dioxide and gold, calcifying nanoparticles, colloidal protein-mineral nanoparticles, Liposomal nanoparticles, MITO-Porter, SB-coated NPs, ASc-loaded polymeric nanoparticles, Carbon-coated iron nanocrystal, Nanodiamonds, Sodium-PLGA hybrid nanoparticles, Epidermal growth factor receptor (EGFR)-targeted chitosan (CS) nanoparticles, Photocaged nanoparticles, Mesoporous silica nanoparticles (MSNs Quantum dots (QDs) which are used for drug delivery patients. For successful management of disease progression of diseases, symptoms should analyze by good physician at an eerily stage, by using highly efficacious, sensitive and specific CKD markers. All factors must include knowing the status of disease and chemotherapeutics by using low toxic nanoparticles. Before being used nanoparticles should evaluate in experiment animal models. For future therapeutics metabolomics, kidney transplants and good wound healers are required.

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Gold-quercetin nanoparticles prevent metabolic endotoxemia-induced kidney injury by regulating TLR4/NF-kB signaling and Nrf2 pathway in high fat diet fed mice

Cited by 61 publications

References 52 publications

A Calorically Restricted High-fat Diet Reverses High-fat Diet-induced Injurious Effects on Health and Gene Expression in Rats

A Calorically Restricted High-fat Diet Reverses High-fat Diet-induced Injurious Effects on Health and Gene Expression in Rats

2'‑Hydroxyflavanone inhibits epithelial‑mesenchymal transition, and cell migration and invasion via suppression of the Wnt/β‑catenin signaling pathway in prostate cancer

Chronic Kidney Diseases and Nanoparticle Therapeutics

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