Gold over Branched Palladium Nanostructures for Photothermal Cancer Therapy

Abstract

Bimetallic nanostructures show exciting potential as materials for effective photothermal hyperthermia therapy. We report the seed-mediated synthesis of palladium-gold (Pd-Au) nanostructures containing multiple gold nanocrystals on highly branched palladium seeds. The nanostructures were synthesized via the addition of a gold precursor to a palladium seed solution in the presence of oleylamine, which acts as both a reducing and a stabilizing agent. The interaction and the electronic coupling between gold nanocrystals and between palladium and gold broadened and red-shifted the localized surface plasmon resonance absorption maximum of the gold nanocrystals into the near-infrared region, to give enhanced suitability for photothermal hyperthermia therapy. Pd-Au heterostructures irradiated with an 808 nm laser light caused destruction of HeLa cancer cells in vitro, as well as complete destruction of tumor xenographs in mouse models in vivo for effective photothermal hyperthermia.

General and programmable synthesis of hybrid liposome/metal nanoparticles

“…S15D). The resonance in the near-infrared region may be due to strong coupling of the collective oscillation of conduction electrons to the interband transitions between Au and Pd atoms ( 10 ). …”

Melatonin Enhances Palladium-Nanoparticle-Induced Cytotoxicity and Apoptosis in Human Lung Epithelial Adenocarcinoma Cells A549 and H1229

“…Pd-Au heterostructures irradiated with an 808 nm laser light destroyed HeLa cancer cells [47]. Biologically synthesized PdNPs potentially induced cytotoxicity in human ovarian cancer cells by reducing cell viability and cell proliferation and increasing ROS [19].…”

Advances in the Application of Magnetic Nanoparticles for Sensing

“…[85,142] Typically, MNPs are coated with PEG or other polymers by first exchanging organic surfactants with small ligands with a strongly binding functional group to the MNP and a second functional group to conjugate the PEG, eg 3-mercaptopropionic acid is anchored with a thiol group to the MNP, and a carboxylic acid group that enables conjugation to amine-terminated PEG. [143] PEG is attached to the conjugated MNPs by sonication in phosphate-buffered saline solution, followed by purification and dispersion in water. Further functionalization with antibodies or analyte-capturing molecules can then be performed, unique to each functional group.…”