Gold nanozyme as an excellent co-catalyst for enhancing the performance of a colorimetric and photothermal bioassay

An, Pengli; Xue, Xin; Rao, Honghong; Wang, Jingjing; Gao, Min; Wang, Hongqiang; Luo, Mingyue; Liu, Xiuhui; Zhang, Xue; Lu, Xiaoquan

doi:10.1016/j.aca.2020.05.047

Cited by 20 publications

(10 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2). Additionally, some materials, such as quantum dots (QDs), 68 β-cyclodextrin (β-CD), 69 polyoxometalates (POMs), 70 polyvinyl alcohol, 71 hydrogel, 72 cysteamine 73 and tannic acid 74 combined with Au NPs showed higher cata-Fig. 1 Schematic diagram of the nanozyme aptasensor prepared by adapting Au NPs to norovirus aptamer.…”

Section: Au-based Nanozymesmentioning

confidence: 99%

“…2). Additionally, some materials, such as quantum dots (QDs), 68 β-cyclodextrin (β-CD), 69 polyoxometalates (POMs), 70 polyvinyl alcohol, 71 hydrogel, 72 cysteamine 73 and tannic acid 74 combined with Au NPs showed higher catalytic activity under neutral conditions, and were successfully utilized for colorimetric detection of metal ions and small biological molecules.…”

Section: Metal-based Nanozymesmentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in colorimetric sensors based on nanozymes with peroxidase-like activity

Chi

Wang

2023

Analyst

View full text Add to dashboard Cite

show abstract

Section: Au-based Nanozymesmentioning

confidence: 99%

“…2). Additionally, some materials, such as quantum dots (QDs), 68 β-cyclodextrin (β-CD), 69 polyoxometalates (POMs), 70 polyvinyl alcohol, 71 hydrogel, 72 cysteamine 73 and tannic acid 74 combined with Au NPs showed higher catalytic activity under neutral conditions, and were successfully utilized for colorimetric detection of metal ions and small biological molecules.…”

Section: Metal-based Nanozymesmentioning

confidence: 99%

Recent advances in colorimetric sensors based on nanozymes with peroxidase-like activity

Chi

Wang

2023

Analyst

View full text Add to dashboard Cite

show abstract

“…In 2007, Yan’s group first found that magnetic Fe 3 O 4 nanoparticles exhibit peroxidase-like activity [ 20 ]. Since then, nanomaterials with enzymatic activity have been widely reported and used in biosensing, bioassay and biomedical fields [ 21 , 22 , 23 , 24 ]. Pranab reported a colorimetric method for the detection of free bilirubin based on the peroxidase-like catalytic activity of gold nanoclusters [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Non-Enzymatically Colorimetric Bilirubin Sensing Based on the Catalytic Structure Disruption of Gold Nanocages

Xiao

Xiong

et al. 2023

Sensors

View full text Add to dashboard Cite

As an essential indicator of liver function, bilirubin is of great significance for clinical diagnosis. A non-enzymatic sensor has been established for sensitive bilirubin detection based on the bilirubin oxidation catalyzed by unlabeled gold nanocages (GNCs). GNCs with dual-localized surface plasmon resonance (LSPR) peaks were prepared by a one-pot method. One peak around 500 nm was ascribed to gold nanoparticles (AuNPs), and the other located in the near-infrared region was the typical peak of GNCs. The catalytic oxidation of bilirubin by GNCs was accompanied by the disruption of cage structure, releasing free AuNPs from the nanocage. This transformation changed the dual peak intensities in opposite trend, and made it possible to realize the colorimetric sensing of bilirubin in a ratiometric mode. The absorbance ratios showed good linearity to bilirubin concentrations in the range of 0.20~3.60 μmol/L with a detection limit of 39.35 nM (3σ, n = 3). The sensor exhibited excellent selectivity for bilirubin over other coexisting substances. Bilirubin in real human serum samples was detected with recoveries ranging from 94.5 to 102.6%. The method for bilirubin assay is simple, sensitive and without complex biolabeling.

show abstract

“…Gold nanoclusters (AuNCs) have ultrasmall sizes (≤2 nm), unique electronic structures, and molecule-like properties. , Thus, they have been widely applied in bionics, biosensing, biomedicine, and particularly mimetic catalysis. , Significant progress of nanomimetic enzymes has been developed to conquer the boundedness of natural enzymes such as instability, high cost, complex purification, and transportation. , Compared with other materials simulating enzymatic activity, AuNCs process the merits of ultrasmall size, nontoxicity, good stability, and biocompatibility . In addition, AuNCs have been used to catalyze H 2 O 2 to produce ROS in vitro and in cells. − The primary process involves the adsorption of H 2 O 2 at the gold surface, and the O–O bonds are broken into dihydroxy radicals; meanwhile, the gold core further stabilizes the generated hydroxyl radicals through partial electron exchange. It enables AuNCs with excellent catalytic capacities for ROS generation.…”

Section: Introductionmentioning

confidence: 99%

Tumor Microenvironments-Adaptive Apoptotic Effects of Cytidine 5′-monophosphate-Capped Gold Nanoclusters

Zhang

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

In the present work, cytidine 5′-monophosphate capped gold nanoclusters (AuNCs@CMP) are reported as a catalyst for redox reactions, which show both oxidase- and excellent peroxidase-like activity. When employing 3,3′,5,5′-tetramethylbenzidine (TMB) as a substrate in the presence of hydrogen peroxide (H2O2), the maximum velocity (V max) was 175 × 10–8 M s–1 in vitro. Besides, the AuNCs@CMP exhibited high catalytic activity for reactive oxygen species (ROS) generation with H2O2. Particularly, they also displayed excellent catalytic activity for ROS generation in tumor cells, being activated and promoted by the tumor microenvironment (TME). Consequently, the AuNCs@CMP show an excellent antitumor effect on HeLa and SW480 cells as assayed by flow cytometry. The antitumor mechanism of AuNCs@CMP was attributed to the high ROS generation based on the specific environments of the TME. Therefore, the present study provides TME-adaptive AuNCs@CMP with excellent mimetic peroxidase activity, producing significant ROS to kill the tumor cells in TME.

show abstract

Gold nanozyme as an excellent co-catalyst for enhancing the performance of a colorimetric and photothermal bioassay

Cited by 20 publications

References 54 publications

Recent advances in colorimetric sensors based on nanozymes with peroxidase-like activity

Recent advances in colorimetric sensors based on nanozymes with peroxidase-like activity

Non-Enzymatically Colorimetric Bilirubin Sensing Based on the Catalytic Structure Disruption of Gold Nanocages

Tumor Microenvironments-Adaptive Apoptotic Effects of Cytidine 5′-monophosphate-Capped Gold Nanoclusters

Contact Info

Product

Resources

About