Gold nanowires to mend a heart

Jaconi, Marisa

doi:10.1038/nnano.2011.195

Cited by 14 publications

(3 citation statements)

References 6 publications

(2 reference statements)

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“…With increasing AuNPs concentration, the proliferation of osteoblasts was enhanced [159]. AuNWs may also direct stem cell differentiation without distortion of growth factors [160]. This finding is revolutionary in the view of functional organ transplantation due to minimizing the side effects of used growth factors in the body.…”

Section: Biologic Propertiesmentioning

confidence: 90%

Nanostructured Materials for Artificial Tissue Replacements

Pryjmaková

Kaimlová

Hubáček

et al. 2020

IJMS

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This paper review current trends in applications of nanomaterials in tissue engineering. Nanomaterials applicable in this area can be divided into two groups: organic and inorganic. Organic nanomaterials are especially used for the preparation of highly porous scaffolds for cell cultivation and are represented by polymeric nanofibers. Inorganic nanomaterials are implemented as they stand or dispersed in matrices promoting their functional properties while preserving high level of biocompatibility. They are used in various forms (e.g., nano- particles, -tubes and -fibers)—and when forming the composites with organic matrices—are able to enhance many resulting properties (biologic, mechanical, electrical and/or antibacterial). For this reason, this contribution points especially to such type of composite nanomaterials. Basic information on classification, properties and application potential of single nanostructures, as well as complex scaffolds suitable for 3D tissues reconstruction is provided. Examples of practical usage of these structures are demonstrated on cartilage, bone, neural, cardiac and skin tissue regeneration and replacements. Nanomaterials open up new ways of treatments in almost all areas of current tissue regeneration, especially in tissue support or cell proliferation and growth. They significantly promote tissue rebuilding by direct replacement of damaged tissues.

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Section: Biologic Propertiesmentioning

confidence: 90%

Nanostructured Materials for Artificial Tissue Replacements

Pryjmaková

Kaimlová

Hubáček

et al. 2020

IJMS

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“…The electrical connectivity provided by these nanoparticles enhanced the maturation of cardiac cells, even in the absence of electrical stimulation . The cardiac cells also showed improved expression of the gap‐junction protein, connexin‐43, which serves to promote electrical signaling between adjacent cardiac cells . Akin to the nanowire‐based hydrogels, nanoparticle hybrid gels also contracted synchronously during electrical stimulation – a graft property that can be exploited to significantly aid in the repair and replacement of injured infarcted myocardium upon transplantation …”

Section: Nanoreinforced Hydrogels For the Regeneration Of Electroactimentioning

confidence: 99%

Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load‐Bearing and Electroactive Tissues

et al. 2016

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Graphene The addition of a protective diluent (e.g., pyrene) to graphite during ball-milling results in a game-changer yield (>90%) of defect-free graphene, as described in article number 1603528 by Matat Buzaglo, Oren Regev, and co-workers. In the non-protected milling, there is a continuous fragmentation leading to amorphous carbon formation, whereas in a diluent-protected milling, the diluent adsorbs part of the impact forces, enabling exfo-liation into graphene, whose size is controlled by the milling energy and the diluent type. A Supercritical Lens Optical Label-Free Microscopy: Sub-Diffraction Resolution and Ultra-Long Working Distance Optical Imaging A planar metalens for achieving super-resolution imaging in far-field is proposed. This metalens, which has a non-sub-wavelength feature size, can be fabricated by conventional laser pattern generator. The imaging process is purely physical and captured in real time, without any pre-and post-processing. A new member of the layered pseudo-1D material family-monoclinic gal-lium telluride (GaTe)-is synthesized by physical vapor transport on a variety of substrates. The [010] atomic chains and the resulting anisotropic behavior are clearly revealed. The GaTe flakes display multiple sharp photoluminescence emissions in the forbidden gap, which are related to defects localized around selected edges and grain boundaries.

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“…These implants, while effective, had a strong mismatch between the device, the pacemaker which was hard and inflexible, and the target tissue, cardiac muscle which is soft and extremely flexible. In contrast, current nanotechnology based cardiac devices can create systems which have properties which more closely resemble the target tissue, such as gold or silicon nanowire scaffolds which are soft and flexible (Bolonduro et al, 2020; Jaconi, 2011; Parameswaran et al, 2019). Alongside suitable mechanical properties these materials also exhibit promising biocompatibility; for instance evidence has shown that gold nanoparticles, once endocytosed, cause a minimal cytokine response and do not exhibit significant cytotoxicity (Fadeel & Garcia‐Bennett, 2010; Shukla et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology

Gibney

Hicks

Robinson

et al. 2021

WIREs Nanomed Nanobiotechnol

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Bioelectronic medicine aims to interface electronic technology with biological components and design more effective therapeutic and diagnostic tools. Advances in nanotechnology have moved the field forward improving the seamless interaction between biological and electronic components. In the lab many of these nanobioelectronic devices have the potential to improve current treatment approaches, including those for cancer, cardiovascular disorders, and disease underpinned by malfunctions in neuronal electrical communication. While promising, many of these devices and technologies require further development before they can be successfully applied in a clinical setting. Here, we highlight recent work which is close to achieving this goal, including discussion of nanoparticles, carbon nanotubes, and nanowires for medical applications. We also look forward toward the next decade to determine how current developments in nanotechnology could shape the growing field of bioelectronic medicine. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > Biosensing

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Gold nanowires to mend a heart

Cited by 14 publications

References 6 publications

Nanostructured Materials for Artificial Tissue Replacements

Nanostructured Materials for Artificial Tissue Replacements

Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load‐Bearing and Electroactive Tissues

Toward nanobioelectronic medicine: Unlocking new applications using nanotechnology

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