Gold-nanourchin seeded single-walled carbon nanotube on voltammetry sensor for diagnosing neurogenerative Parkinson’s disease

Zhang, Rui; Wang, Shan; Huang, Xiaoming; Yang, Yihang; Fan, Haitao; Yang, Fan; Li, Jie; Dong, Xushuai; Feng, Shaobin; Anbu, Periasamy; Gopinath, Subash C.B.; Xin, Tao

doi:10.1016/j.aca.2019.10.012

Cited by 52 publications

(45 citation statements)

References 44 publications

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“…The special nanostructure enables carbon nanotubes (CNTs) to deliver high concentration of anticancer drugs, which has a promising application prospect in targeted therapy. [ 5 ] Unlike other drug carriers, CNTs are tubular materials. During the synthesis process, anticancer drugs can be adsorbed into the tube of CNTs, further reducing the sudden release.…”

Section: Figurementioning

confidence: 99%

Construction of Aptamer‐siRNA Chimera/PEI/5‐FU/Carbon Nanotube/Collagen Membranes for the Treatment of Peritoneal Dissemination of Drug‐Resistant Gastric Cancer

Chen

Yang

et al. 2020

Adv Healthcare Materials

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Due to extensive metastasis, poor blood supply, and drug-resistant, there is still no effective clinical means to treat peritoneal dissemination of gastric cancer. Here, an aptamer-siRNA chimera (Chim)/polyethyleneimine (PEI)/5-fluorouracil (5-FU)/carbon nanotube (CNT)/collagen membrane is constructed, which could be divided into 15 layers with a thickness of 70-100 µm. Sustained release experiments show that the collagen membranes can control 5-FU release for more than 2 weeks. Aptamer-siRNA chimera can specifically bind to gastric cancer cells, enabling targeted delivery of 5-FU and silencing drug-resistant gene. In vitro experiments demonstrated that Chim/PEI/5-FU/CNT nanoparticles promoted the apoptosis of 5-FU-resistant gastric cancer cells, inhibited their invasion and proliferation. Animal experiments show that Chim/PEI/5-FU/CNT/collagen membrane significantly inhibits the expression of mitogen-activated protein kinase (MAPK), and effectively treats peritoneal dissemination of 5-FU-resistant gastric cancer. Compared with siRNA/PEI/5-FU/CNT group, ki-67 proliferation index, and matrix metallopeptidase 9 (MMP9) expression are significantly decreased in the Chim/PEI/5-FU/CNT group, while the proportion of apoptotic cells is markly increased. In conclusion, a chimera/PEI/5-FU/CNT/collagen membrane is constructed, which can effectively treat peritoneal dissemination of drug-resistant gastric cancer. The study provides a new therapeutic approach for relevant clinical treatment.

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Section: Figurementioning

confidence: 99%

Construction of Aptamer‐siRNA Chimera/PEI/5‐FU/Carbon Nanotube/Collagen Membranes for the Treatment of Peritoneal Dissemination of Drug‐Resistant Gastric Cancer

Chen

Yang

et al. 2020

Adv Healthcare Materials

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“…IDE is an established transducing system, widely used in various applications, especially in the field of biosensor to diagnose the range of diseases by its easier fabrication process, inexpensiveness, and higher sensitivity [22,23]. These bring out the inherent advantages with the additional advantages such as portability, real-time output, and high performance [24][25][26][27]. In general, IDE sensor has involved a selective recognition of biological elements; it converted into an electric signal with the help of transducer.…”

Section: Highlightsmentioning

confidence: 99%

DNA–RNA complementation on silicon wafer for thyroid cancer determination

Gopinath

Xuan

2020

Biotech and App Biochem

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One of the current issues with thyroid tumor is early diagnosis as it makes the higher possibility of curing. This research was focused to detect and quantify the level of specific target sequence complementation of miR-222 with capture DNA sequence on interdigitated electrode (IDE) sensor. The aluminum electrode with the gap and finger sizes of 10 μm was fabricated on silicon wafer, further the surface was amine-functionalized for accommodating carboxylated-DNA probe. With DNA-target RNA complementation, the detection limit was attained to be 1 fM as estimated by a linear regression analysis [y = 1.5325x -2.1171 R 2 = 0.9065] and the sensitivity was at the similar level. Current responses were higher by increasing the target RNA sequence concentrations. Control experiments with mismatched/noncomplementary sequences were failed to complement the capture DNA sequence immobilized on IDE, indicating the specific target validation. This research helps diagnosing and identifying the progression with thyroid tumor and miRNA being a potential "marker" in atypia diagnosis.

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“…Identifying and diagnosing PD with an ideal biomarker is mandatory to give the proper follow-up treatment. 3 Neurofilament light chain (NfL) is a neuronal cytoplasmic protein, expressed highly in the area of myelinated axons. Researchers found that the level of NfL is increasing in blood and cerebrospinal fluids proportionally and cause neurological disorders, such as traumatic, neurogenerative, and PD.…”

Section: Introductionmentioning

confidence: 99%

Gold-nanourchin complexed silicon dioxide-probe on gap-fingered interdigitated electrode surface for Parkinson’s Disease determination by current–volt measurement

Shi²,

Zhang

et al. 2021

Nanomaterials and Nanotechnology

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Parkinson’s disease (PD) is a nervous disorder, affects physical movement, and leads to difficulty in balancing, walking, and coordination. A novel sensor is mandatory to determine PD and monitor the progress of the treatment. Neurofilament light chain (NfL) has been recognized as a good biomarker for PD and also helps to distinguish between PD and atypical PD syndromes. Immunosensor was generated by current–volt measurement on gap-fingered interdigitated electrode with silicon dioxide surface to determine NfL level. To enhance the detection, anti-NfL antibody was complexed with gold-nanourchin and immobilized on the sensing electrode. The current–volt response was gradually increased at the linear detection range from 100 fM to 1 nM. Limit of detection and sensitivity were 100 fM with the signal-to-noise ratio at n = 3 on a linear curve ( y = 0.081 x + 1.593; R 2 = 0.9983). Limit of quantification falls at 1 pM and high performance of the sensor was demonstrated by discriminating against other neurogenerative disease markers, in addition, it was reproducible even in serum-spiked samples. This method of detection system aids to measure the level of NfL and leads to determine the condition with PD.

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Gold-nanourchin seeded single-walled carbon nanotube on voltammetry sensor for diagnosing neurogenerative Parkinson’s disease

Cited by 52 publications

References 44 publications

Construction of Aptamer‐siRNA Chimera/PEI/5‐FU/Carbon Nanotube/Collagen Membranes for the Treatment of Peritoneal Dissemination of Drug‐Resistant Gastric Cancer

Construction of Aptamer‐siRNA Chimera/PEI/5‐FU/Carbon Nanotube/Collagen Membranes for the Treatment of Peritoneal Dissemination of Drug‐Resistant Gastric Cancer

DNA–RNA complementation on silicon wafer for thyroid cancer determination

Gold-nanourchin complexed silicon dioxide-probe on gap-fingered interdigitated electrode surface for Parkinson’s Disease determination by current–volt measurement

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