Gold nanostructure materials in diabetes management

Si, Satyabrata; Pal, Arttatrana; Mohanta, Jagdeep; Satapathy, S.

doi:10.1088/1361-6463/aa5e21

Cited by 11 publications

(8 citation statements)

References 92 publications

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“…There is a great possibility for their interaction with macrophages and to influence atherosclerosis. 14,15 The inhibitory effect of AuNPs against oxidative-nitrosative stress and inactivation of NF-κB that deregulates the expression of diverse inflammatory mediators and immune response genes are lacking. The present study aims to understand the basic mechanism and pathways of inhibitory activity of AuNPs on HG-induced ROS/RNS production, antioxidant depletion, biomolecules damage, inflammation and apoptosis, which is explained by phosphorylation of NF-κB via ERK1/2MAPK/Akt/tuberin-mammalian target of rapamycin (mTOR) pathways in macrophages.…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-κB pathways in macrophages

Rizwan

Mohanta

et al. 2017

IJN

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Hyperglycemia is a risk factor for cardiovascular mortality and morbidity, and directly responsible for exacerbating macrophage activation and atherosclerosis. We showed that gold nanoparticles (AuNPs) reduce the high glucose (HG)-induced atherosclerosis-related complications in macrophages via oxidative-nitrosative stress-regulated inflammation and apoptosis. The effects of AuNPs on oxidative-nitrosative stress markers such as cellular antioxidants were attenuated by HG exposure, leading to reduction in the accumulation of reactive oxygen/nitrogen species in cellular compartments. Further, these abnormalities of antioxidants level and reactive oxygen/nitrogen species accumulations initiate cellular stress, resulting in the activation of nuclear factor κB (NF-κB) via ERK1/2mitogen-activated protein kinase (MAPK)/Akt/tuberin-mammalian target of rapamycin (mTOR) pathways. The activated NF-κB stimulates inflammatory mediators, which subsequently subdue biomolecules damage, leading to aggravation of the inflammatory infiltration and immune responses. Treatment of AuNPs inhibits the intracellular redox-sensitive signaling pathways, inflammation, and apoptosis in macrophages. Together, our results indicate that AuNPs may modulate HG-induced oxidative-nitrosative stress. These effects may be sealed tight due to the fact that AuNPs treatment reduces the activation of NF-κB by ERK1/2MAPK/Akt/tuberin-mTOR pathways-mediated inflammatory genes expression and cellular stress responses, which may be beneficial for minimizing the atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-κB pathways in macrophages

Rizwan

Mohanta

et al. 2017

IJN

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“…For medical applications, noble metal nanostructures are of particular interest. Pure and capped silver and gold particles are widely used for cancer treatment, biomedical imaging, drug delivery, diabetes management, and antibacterial material and drug supplements [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Silver Vapor Supersonic Jets: Expansion Dynamics, Cluster Formation, and Film Deposition

et al. 2023

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Supersonic jets of metal vapors with carrier gas are promising for producing nanostructured metal films at relatively low source temperatures and high deposition rates. However, the effects of the carrier gas on the jet composition and expansion dynamics, as well as on film properties, remain virtually unexplored. In this work, the free-jet expansion of a mixture of silver vapor with helium in a rarefied regime at an initial temperature of 1373 K is investigated through mass spectrometry and direct-simulation Monte Carlo methods. Introducing the carrier gas into the source is found to result in a transition from a collisionless to a collision-dominated expansion regime and dramatic changes in the Ag jet, which becomes denser, faster, and more forward-directed. The changes are shown to be favorable for the formation of small Ag clusters and film deposition. At a fairly high helium flow, silver Ag2 dimers are observed in the jet, both in the experiment and the simulations, with a mole fraction reaching 0.1%. The terminal velocities of silver atoms and dimers are nearly identical, indicating that the clusters are likely formed due to the condensation of silver vapor in the expanding jet. A high potential of supersonic Ag-He jets for the deposition of nanostructured silver films is demonstrated. The deposited jet Ag2 dimers appear to serve as nucleation centers and, thus, allow for controlling the size of the produced surface nanostructures.

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“…So far, some nanomaterials with antidiabetic properties have been reported, including silver nanoparticles (Saratale et al, 2018), zinc oxide nanoparticles (Rehana et al, 2017), gold nanoparticles (Si et al, 2017), NE of fenugreek oil (Hassan & Mujtaba, 2017), and NE of carvacrol (Hussein et al, 2017). Today, the use of plants plays a vital role in nanotechnology (Hajiashrafi & Motakef, 2018).…”

Section: Introductionmentioning

confidence: 99%

Preparation of O/W nano-emulsion containing nettle and fenugreek extract and cumin essential oil for evaluating antidiabetic properties

2021

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The oil-in-water (O/W) nano-emulsion (NE) is expanded to enhance the bioavailability of hydrophobic compounds. The NE can be prepared by herbal extract and essential oil as herbal medicines for antidiabetic treatment. In the present study, the O/W NE was prepared by fenugreek extract (FE), nettle extract (NE), and cumin essential oil (CEO) using tween 80 and span 80 surfactants in an ultrasonic bath, at room temperature within 18 min. The antidiabetic property was evaluated by determining glucose absorption using cultured rat L6 myoblast cell line (L6) myotubes and insulin secretion using the cultured mouse pancreatic beta-cell (RIN-5) for NEs. The samples were investigated by dynamic light scattering (DLS) to examine the size distribution and size, zeta potential for the charge determination, scanning electron microscopy (SEM), and transmission electron microscopy (TEM) to investigate morphology and size. The rheological properties were studied by viscosity. The sample stability was evaluated at different temperatures and days by DLS and SEM analyses. The cytotoxicity of samples was explored by MTT assay for HEK293 human cell line as a specific cell line originally derived from human embryonic kidney cells at three different concentrations for three periods of time. The NEs with nanometer-size were observed with antidiabetic properties, low cytotoxicity, and suitable stability. This study provides definitive evidence for the NE as a plant medicine with antidiabetic properties. The NE can be a good candidate for biomedical applications.

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Gold nanostructure materials in diabetes management

Cited by 11 publications

References 92 publications

Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-κB pathways in macrophages

Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-κB pathways in macrophages

Silver Vapor Supersonic Jets: Expansion Dynamics, Cluster Formation, and Film Deposition

Preparation of O/W nano-emulsion containing nettle and fenugreek extract and cumin essential oil for evaluating antidiabetic properties

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Gold nanostructure materials in diabetes management

Cited by 11 publications

References 92 publications

Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-&kappa;B pathways in macrophages

Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-&kappa;B pathways in macrophages

Silver Vapor Supersonic Jets: Expansion Dynamics, Cluster Formation, and Film Deposition

Preparation of O/W nano-emulsion containing nettle and fenugreek extract and cumin essential oil for evaluating antidiabetic properties

Contact Info

Product

Resources

About

Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-κB pathways in macrophages

Gold nanoparticles reduce high glucose-induced oxidative-nitrosative stress regulated inflammation and apoptosis via tuberin-mTOR/NF-κB pathways in macrophages