Gold nanostars for efficient in vitro and in vivo real-time SERS detection and drug delivery via plasmonic-tunable Raman/FTIR imaging

Tian, Furong; Conde, João; Bao, Chunyan; Chen, Yunsheng; Curtin, James F.; Cui, Daxiang

doi:10.1016/j.biomaterials.2016.08.014

Cited by 123 publications

(93 citation statements)

References 43 publications

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“…The radiative properties of gold nanoparticles including absorption, scattering and localized surface plasmon resonance (LSPR) make them very suitable for photothermal therapy and molecular cancer imaging. While the easiness for surface modification enables them very suitable for drug delivery (Tian et al, 2016) and cancer therapies.…”

Section: Gold Nanoparticles For Targeting Cscsmentioning

confidence: 99%

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

et al. 2017

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Cancer stem cells (CSCs) have been identified in almost all cancers and give rise to metastases and can also act as a reservoir of cancer cells that may cause a relapse after surgery, radiation, or chemotherapy. Thus they are obvious targets in therapeutic approaches and also a great challenge in cancer treatment. The threat presented by CSCs lies in their unlimited proliferative ability and multidrug resistance. These findings have necessitated an effective novel strategy to target CSCs for cancer treatment. Nanomaterials are on the route to providing novel methods in cancer therapies. Although, there have been a large number of excellent work in the field of targeted cancer therapy, it remains an open question how nanomaterials can meet future demands for targeting and eradicating of CSCs. In this review, we summarized recent and highlighted future prospects for targeting CSCs for cancer therapies by using a variety of nanomaterials.

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Section: Gold Nanoparticles For Targeting Cscsmentioning

confidence: 99%

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

et al. 2017

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“…More recently developed probes include Au nanostars (AuNSs), which can be functionalized with the anticancer drug mitoxantrone (MTX). The distinct Raman spectrum of MTX, combined with the significant SERS enhancement from the nanostars, allows one to track delivery and release of MTX in vivo and in real-time using SERS 99 . Related work has illustrated the value of AuNSs in SERS imaging as well as PTT in vivo (FIG.…”

Section: [H1] Key Advances In In Vivo Sensingmentioning

confidence: 99%

“…Au NPs have unique optical properties, biocompatibility and ease of functionalization that makes them particularly suitable in drug delivery, 95,99,148 controlled DNA release, [149][150][151] active tumour targeting, 52,118,144 photodynamic therapy (PDT) 94,152 and PTT. 92,98,100,153 Additionally, the use of NPs in these applications provides enhanced signals in Raman imaging and allows the processes to be monitored using SERS.…”

Section: [H1] Key Advances In In Vivo Sensingmentioning

confidence: 99%

“…In addition to diagnostics, SERS has been used for intraoperative guidance for tumour removal, 54 and, when in combination with drug delivery and PTT, enables targeted tumour detection and treatment. 55 We will highlight prominent examples in these areas, describing the challenges that have already been overcome, as well as those that still need to be addressed before these analytical tools find clinical use.…”

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Surface-enhanced Raman spectroscopy for in vivo biosensing

et al. 2017

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| Surface enhanced Raman scattering (SERS) is of interest for biomedical analysis and imaging due to its sensitivity, specificity and multiplexing capabilities. The successful application of SERS for in vivo biosensing necessitates probes to be biocompatible and procedures to be minimally invasive, challenges that have respectively been met by the design of nanoprobes and instrumentation. This Review presents recent developments in these areas, describing case studies in which sensors have been implemented, as well as outlining shortcomings that have to be addressed before SERS sees clinical use.In 1928, C. V. Raman first reported the scattering phenomenon that now bears his name.1,2 Raman scattering has since become a powerful analytical technique, including for biomedical applications, 3 where label-free and objective tissue diagnostics 4-6 ex vivo and in vivo, as well as drug-cell interaction studies in vitro have been conducted. [7][8][9] The majority of incident photons experience elastic (Rayleigh) scattering, with only about 1 in 10 7 photons undergoing inelastic (Raman) scattering. 10 In 1974, Fleischmann and co-workers described a phenomenon that would later become known as surface enhanced Raman scattering (SERS) 11 . They observed a large enhancement in inelastic scattering from pyridine when the analyte was adsorbed onto a Ag electrode, an effect that had previously been mentioned by the team of A. J. McQuillan in 1973, 12 with Van Duyne later attributing the signal enhancement to the roughened metal surface via the physical phenomenon he coined SERS.13 Unlike conventional Raman spectroscopy, SERS analyses require samples to be labelled, a disadvantage offset by the large intensity enhancement that makes SERS an important analytical tool with high sensitivity and low detection limits.14,15 The exact mechanism of SERS is not fully understood but an electromagnetic enhancement factor plays the major role 16 , whereby free electrons in a metal nanoparticle (NP) encounter applied radiation whose electromagnetic field varies at a frequency matching the oscillation frequency of electrons in the NPs. Such plasmon resonance at the NP surface arises from an intense electric field, which intensifies Raman modes arising from molecules near or attached to the NP surface. The Raman signals can also be enhanced due to the formation of chargetransfer complexes between the roughened metal surface and molecules bound to it. We now leave our discussion of the SERS mechanism, but refer readers interested in these fundamental principles to some comprehensive articles on the subject. [17][18][19] Well-known selection rules allow for one to predict if a given vibrational mode is infrared-and/or Raman-active. Indeed, by considering the magnitude of the change in dipole moment or polarizability associated with a vibration, one can rationalize infrared or Raman data, respectively. Compared to Raman spectroscopy, SERS involves analyte molecules interacting with a roughened metal substrate, such that the symmetry ...

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“…Gold or silver nanoparticles can serve in cells also as labels that highlight cellular structures based on the surface enhanced Raman signature of a reporter molecule linked to them [49]. Tian et al [50] proposed a new theranostic strategy based on an efficient plasmonictunable Raman/Fourier transform infrared (FTIR) spectroscopy imaging, to simultaneously evaluate the anticancer drug scattering cellular imaging and the Raman scattering molecular vibration signals in living cells (Fig. 5).…”

Section: Chemical Probes In Live Cellsmentioning

confidence: 99%

Surface Enhanced Raman Scattering (SERS): From Fundamental Mechanism to Bio-Analytics Tools

Zhi¹,

Liu²,

Chen³

2016

Nano BioMed ENG

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This review discusses the surface-enhanced Raman scattering (SERS) with efficiencies enhanced by as much as 10 14 -10 15 fold as well as a SERS cross section on the order of 10 -17 -10 -16 cm 2 / molecule. Despite the existing controversy on the origin of the enhancement, SERS effect offers new opportunities for spectroscopic detection of single molecules near or on the surface of metallic nanoparticles. There has been a considerable amount of research on explanation of the enhancement mechanism and on developing SERS labels as bio-analytics tools for either molecular multiplexed detection or bio-imaging at different levels.

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Gold nanostars for efficient in vitro and in vivo real-time SERS detection and drug delivery via plasmonic-tunable Raman/FTIR imaging

Abstract: 2016). Gold nanostars for efficient in vitro and in vivo real-time SERS detection and drug delivery via plasmonic-tunable Raman/FTIR imaging. Biomaterials, vo.106,

Cited by 123 publications

References 43 publications

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy

Surface-enhanced Raman spectroscopy for in vivo biosensing

Surface Enhanced Raman Scattering (SERS): From Fundamental Mechanism to Bio-Analytics Tools

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