Gold Nanospheres-Stabilized Indocyanine Green as a Synchronous Photodynamic–Photothermal Therapy Platform That Inhibits Tumor Growth and Metastasis

Li, Wei; Zhang, Hanbo; Guo, Xiaomeng; Wang, Zuhua; Kong, Fenfen; Luo, Lihua; Li, Qingpo; Zhu, Chunqi; Yang, Jie; Lou, Yan; Du, Yong‐Zhong; You, Jian

doi:10.1021/acsami.6b13351

Cited by 80 publications

(69 citation statements)

References 54 publications

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“…[324][325][326][327][328][329] Synergistic surgery with multimodal ablations have been expected to achieve high antitumor efficacy and good surgical outcomes. [324][325][326][327][328][329] Synergistic surgery with multimodal ablations have been expected to achieve high antitumor efficacy and good surgical outcomes.…”

Section: Other Synergistic Surgerymentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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Section: Other Synergistic Surgerymentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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“…However, these organic molecules possess poor physiological stability, which impeded their clinical application. With the assistance of nanotechnology, nanocomposites were introduced to overcome the shortcoming . Guo et al.…”

Section: Deep Pdtmentioning

confidence: 99%

“…With the assistance of nanotechnology, nanocomposites were introduced to overcome the shortcoming. [43][44][45] Guo et al reported a cypate and Chlorin e6 (Ce6) co-loaded micelle system for imaging-guided photodynamic /photothermal therapy (PTT) ( Figure 1). [46] The system exhibited enhanced photostability, cellular uptake and tumor accumulation.…”

Section: Nir Light Excited Deep Pdtmentioning

confidence: 99%

Integration of Self‐Luminescence and Oxygen Self‐Supply: A Potential Photodynamic Therapy Strategy for Deep Tumor Treatment

Jiang

Liu

et al. 2020

ChemPlusChem

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Photodynamic therapy (PDT), as an emerging clinical approach, has been exploited for the treatment of various diseases including cancer for several years. Excitation light and molecular oxygen are the key parameters that restrict the efficacy of PDT due to the restricted penetration depth of light and the hypoxic microenvironment of tumors, which will lead to ineffective therapeutic response. In recent years, a number of studies were focused on tackling these challenges and showed great potential in improving the efficacy of PDT to some degree. Herein, we summarize the advancements in newly developed PDT strategies based on diverse nanocomposites, especially in the aspects of the types of light source and the ways to supply oxygen. Finally, new challenges and possible opportunities for further research are also discussed.

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“…However, the poor stability restricted the usage of ICG in clinic. Several nanostructures were introduced to overcome the limitation (Gao et al, ; Khatri et al, ; Li et al, ; Shemesh, Moshkelani, & Zhang, ; Sun et al, ). Recently, Hu et al combined hydroxyethyl starch‐oleic acid conjugate based nanoparticles with β‐Phenylethyl isothiocyanate to encapsulate ICG.…”

Section: Nanocarriers Used In Deep Pdtmentioning

confidence: 99%

Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers

Zhao

Wang

et al. 2019

WIREs Nanomed Nanobiotechnol

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Photodynamic therapy (PDT) has been used in the treatment of cancers and other benign diseases for several years in clinic. However, the hypoxia of tumors and the penetration limitation of excitation light to tissues can dramatically reduce the efficacy of PDT to cancers. To overcome these drawbacks, various assembled nanocarriers such as nanoparticles, nanocapsules, nanocrystals, and so on were introduced. The assembled nanocarriers have the ability of loading photosensitizers, delivering O2 into tumors, generating O2 in situ in tumors, as well as turning near‐infrared (NIR) light, X‐rays, and chemical energy into ultraviolet or visible light. Therefore, it is easy for the nanocarriers to improve the hypoxia microenvironment or increase the treatment depth of cancers, which will improve the efficiency of PDT to some degree. In recent years, a number of investigations were focused on these subjects. We will summarize the advances of nanocarriers in PDT, especially in O2 introduction PDT and deep PDT. The perspectives, challenges, and potential in translation of PDT will also be discussed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology‐Inspired Nanomaterials > Lipid‐Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Gold Nanospheres-Stabilized Indocyanine Green as a Synchronous Photodynamic–Photothermal Therapy Platform That Inhibits Tumor Growth and Metastasis

Cited by 80 publications

References 54 publications

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Integration of Self‐Luminescence and Oxygen Self‐Supply: A Potential Photodynamic Therapy Strategy for Deep Tumor Treatment

Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers

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