Gold Nanoshell-Decorated Silicone Surfaces for the Near-Infrared (NIR) Photothermal Destruction of the Pathogenic Bacterium <i>E. faecalis</i>

Khantamat, Orawan; Li, Chien-Hung; Yu, Zhi Qiang; Jamison, Andrew C.; Shih, Wei-Chuan; Cai, Chengzhi; Lee, T. Randall

doi:10.1021/am506516r

Cited by 80 publications

(62 citation statements)

References 72 publications

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“…The efficacy of nanoparticles, especially metal-based nanoparticles against E . faecalis biofilms has been well documented [55, 56]. Although most nanoparticle systems used for treating biofilms contain metals or drugs, nanoformulations with natural products offer broader potential for therapy.…”

Section: Discussionmentioning

confidence: 99%

Chitosan-propolis nanoparticle formulation demonstrates anti-bacterial activity against Enterococcus faecalis biofilms

et al. 2017

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Propolis obtained from bee hives is a natural substance with antimicrobial properties. It is limited by its insolubility in aqueous solutions; hence ethanol and ethyl acetate extracts of Malaysian propolis were prepared. Both the extracts displayed antimicrobial and anti-biofilm properties against Enterococcus faecalis, a common bacterium associated with hospital-acquired infections. High performance liquid chromatography (HPLC) analysis of propolis revealed the presence of flavonoids like kaempferol and pinocembrin. This study investigated the role of propolis developed into nanoparticles with chitosan for its antimicrobial and anti-biofilm properties against E. faecalis. Bacteria that grow in a slimy layer of biofilm are resistant to penetration by antibacterial agents. The use of nanoparticles in medicine has received attention recently due to better bioavailability, enhanced penetrative capacity and improved efficacy. A chitosan-propolis nanoformulation was chosen based on ideal physicochemical properties such as particle size, zeta potential, polydispersity index, encapsulation efficiency and the rate of release of the active ingredients. This formulation inhibited E. faecalis biofilm formation and reduced the number of bacteria in the biofilm by ~90% at 200 μg/ml concentration. When tested on pre-formed biofilms, the formulation reduced bacterial number in the biofilm by ~40% and ~75% at 200 and 300 μg/ml, respectively. The formulation not only reduced bacterial numbers, but also physically disrupted the biofilm structure as observed by scanning electron microscopy. Treatment of biofilms with chitosan-propolis nanoparticles altered the expression of biofilm-associated genes in E. faecalis. The results of this study revealed that chitosan-propolis nanoformulation can be deemed as a potential anti-biofilm agent in resisting infections involving biofilm formation like chronic wounds and surgical site infections.

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Section: Discussionmentioning

confidence: 99%

Chitosan-propolis nanoparticle formulation demonstrates anti-bacterial activity against Enterococcus faecalis biofilms

et al. 2017

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“…Photothermal therapy consists of the remote activation of the plasmon field of nanoparticles by irradiation with a resonant light wavelength, leading to a local increase in temperature [3]. This localized heating can kill cancer cells and tissue in an effective manner, with no drugs or biochemical treatment required [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Ion-Mediated Aggregation of Gold Nanoparticles for Light-Induced Heating

et al. 2017

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Featured Application: Photothermal therapy is a highly promising strategy for killing cancer cells and tissues that can be applied in vivo.Abstract: Photothermal therapy is proposed as a straightforward manner of killing cancer cells, which a plasmon field of gold nanoparticles is activated by incoming light resonance leading to a local increase of temperature. This photothermal effect is strongly dependent on the plasmonic features of the nanoparticles. Herein, we study the effect of the ion-mediated aggregation of citrate-capped small spherical gold nanoparticles on the plasmonic band and the photothermal performance. An intermediate value of ionic strength has been found to be optimum with respect to the photothermal capabilities of the gold nanoparticles.

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“…Recently, Khantamat et al introduced a photoactive‐based coating of Au NSs‐decorated silicone surfaces for the near‐infrared (NIR) photothermal destruction of the pathogenic bacterium E. faecalis (Fig. ) …”

Section: Antimicrobial Strategies For Urinary Cathetersmentioning

confidence: 99%

“…15). 154 Copper nanoparticle coatings. Copper-based nanoparticles, such as copper oxide (CuO) NPs, have been applied for anti-fouling coating.…”

Section: Bacterial Interferencementioning

confidence: 99%

Antimicrobial strategies for urinary catheters

Zhu

Wang

et al. 2018

J Biomedical Materials Res

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Over 75% of hospital‐acquired or nosocomial urinary tract infections are initiated by urinary catheters, which are used during the treatment of 16% of hospitalized patients. Taking the United States as an example, the costs of catheter‐associated urinary tract infections (CAUTI) are in excess of $451 million dollars/year. The biofilm formation by pathogenic microbes that protects pathogens from host immune defense and antimicrobial agents is the leading cause for CAUTI. Thus, tremendous efforts have been devoted to antimicrobial coating for urinary catheters in the past few decades, and it has been demonstrated to be one of the most direct and efficient strategies to reduce infections. In this article, we briefly summarize the current methods for preparation of antimicrobial coatings based on different stages in the biofilm formation, highlight recent progress in the urinary catheter coating material design and selection, discuss approaches to improving their long‐term antimicrobial efficacy, biocompatibility, multidrug resistance and recurrent infections, and finally outline future requirements and prospects in antimicrobial coating material design. The scope of the works surveyed is confined to antimicrobial urinary catheters. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 445–467, 2019.

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Gold Nanoshell-Decorated Silicone Surfaces for the Near-Infrared (NIR) Photothermal Destruction of the Pathogenic Bacterium E. faecalis

Cited by 80 publications

References 72 publications

Chitosan-propolis nanoparticle formulation demonstrates anti-bacterial activity against Enterococcus faecalis biofilms

Chitosan-propolis nanoparticle formulation demonstrates anti-bacterial activity against Enterococcus faecalis biofilms

Ion-Mediated Aggregation of Gold Nanoparticles for Light-Induced Heating

Antimicrobial strategies for urinary catheters

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