Gold nanoshell bioconjugates for molecular imaging in living cells

Loo, Christopher; Hirsch, Leon; Lee, Minho; Chang, Emmanuel; West, Jennifer L.; Halas, Naomi J.; Drezek, Rebekah A.

doi:10.1364/ol.30.001012

Cited by 291 publications

(204 citation statements)

References 15 publications

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“…Their NIR resonances could enable investigation deeper into tissue and even the possibility of diagnostic imaging with exogenous illumination and detection. Bioconjugated gold nanoshells [39][40][41], gold nanocages [19,21] and gold nanorods [42] are being developed for this purpose. These nanoparticles have been conjugated to specifically target cancer cells in vitro, where their specificity has been confirmed by dark-field optical microscopy ( Figure 3).…”

Section: Biomedical Imaging Contrastmentioning

confidence: 99%

Biomedical Applications of Plasmon Resonant Metal Nanoparticles

2006

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The strong optical absorption and scattering of noble metal nanoparticles is due to an effect called localized surface plasmon resonance, which enables the development of novel biomedical applications. The resonant extinction, which can be tuned to the near-infrared, allows the nanoparticles to act as molecular contrast agents in a spectral region where tissue is relatively transparent. The localized heating due to resonant absorption, also tunable into the near-infared, enables new thermal ablation therapies and drug delivery mechanisms. The sensitivity of these resonances to their environment leads to simple affinity sensors for the detection of low-level molecular analytes. Coupled with their general lack of toxicity, these applications suggest that noble metal nanoparticles are a highly promising class of nanomaterials for new biomedical applications.

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Section: Biomedical Imaging Contrastmentioning

confidence: 99%

Biomedical Applications of Plasmon Resonant Metal Nanoparticles

2006

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“…The resonant excitation of plasmons can lead to large local enhancements of the incident electromagnetic field at the nanoparticle surface, resulting in dramatically large enhancements of the cross section for nonlinear optical spectroscopies such as surface-enhanced Raman scattering (12)(13)(14)(15)(16). The structural dependence of both the local-field and far-field optical properties of nanoparticles across the visible and near-infrared (NIR) spectral regions has enabled their use in a wide range of biomedical applications, an area of increasing importance and societal impact (17)(18)(19)(20)(21).…”

mentioning

confidence: 99%

Symmetry breaking in individual plasmonic nanoparticles

Wang

Lassiter

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

283

289

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The plasmon resonances of a concentric metallic nanoshell arise from the hybridization of primitive plasmon modes of the same angular momentum on its inner and outer surfaces. For a nanoshell with an offset core, the reduction in symmetry relaxes these selection rules, allowing for an admixture of dipolar components in all plasmon modes of the particle. This metallodielectric nanostructure with reduced symmetry exhibits a core offset-dependent multipeaked spectrum, seen in single-particle spectroscopic measurements, and exhibits significantly larger local-field enhancements on its external surface than the equivalent concentric spherical nanostructure.nanostructures ͉ plasmon hybridization ͉ spectroscopy T he optical properties of metallic nanostructures are a topic of considerable scientific and technological importance. The optical properties of a metallic nanoparticle are determined by its plasmon resonances, which are strongly dependent on particle geometry. The structural tunability of plasmon resonances has been one of the reasons for the growing interest in a rapidly expanding array of nanoparticle geometries, such as nanorods (1, 2), nanorings (3), nanocubes (4, 5), triangular nanoprisms (6-8), nanoshells (9), and branched nanocrystals (10, 11). The resonant excitation of plasmons can lead to large local enhancements of the incident electromagnetic field at the nanoparticle surface, resulting in dramatically large enhancements of the cross section for nonlinear optical spectroscopies such as surface-enhanced Raman scattering (12-16). The structural dependence of both the local-field and far-field optical properties of nanoparticles across the visible and near-infrared (NIR) spectral regions has enabled their use in a wide range of biomedical applications, an area of increasing importance and societal impact (17-21).Metallic nanoshells, composed of a spherical dielectric core surrounded by a concentric metal shell, support plasmon resonances whose energies are determined sensitively by inner core and outer shell dimensions (9). This geometric dependence arises from the hybridization between cavity plasmons supported by the inner surface of the shell and the sphere plasmons of the outer surface (22,23). This interaction results in the formation of two hybridized plasmons, a low-energy symmetric or ''bonding'' plasmon and a high-energy antisymmetric or ''antibonding'' plasmon mode. The bonding plasmon interacts strongly with an incident optical field, whereas the antibonding plasmon mode interacts only weakly with the incident light and can be further damped by the interband transitions in the metal (24). For a spherically symmetric nanoshell, where the center of the inner shell surface is coincident with the center of the outer shell surface, plasmon hybridization only occurs between cavity and sphere plasmon states of the same angular momentum, denoted by multipolar index l (⌬l ϭ 0). In the dipole, or electrostatic limit, only the l ϭ 1 dipolar bonding plasmon is excited by an incident optical plane wave ...

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“…According to a study by plasmonic nanoparticles to image EGFR in live cells, dark-field microspectroscopy and labeled plasmonic nanoparticles have the potential utility for LCI [79]. Nanoshell bioconjugates can effectively target and image human epidermal growth factor receptor 2 (HER2), a clinically relevant biomarker, in live human breast carcinoma cells [80].…”

Section: Epithelium Specific Probesmentioning

confidence: 99%

Application of Probes in Live Cell Imaging~!2010-01-03~!2010-05-09~!2010-08-16~!

Chen¹,

Bai²,

Wang³

2010

JEBP

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Live cell imaging (LCI) is the approach of non-invasively analyzing dynamic processes in living cells using state-of-the-art microscopy and computer vision techniques. LCI provides exciting and novel insights into cell biology. The present review summarized LCI research in recent years and detailed the role of probes in LCI. We discussed the basic principle and development in LCI technology, including fluorecence resonance energy transfer, fluorescence lifetime imaging microscopy, atomic force microscopy, scanning ion conductance microscopy, confocal microscopy, two-photon excitation fluorescence microscopy and Cell-IQ® System . Then we listed several probes such as green fluorescent protein and quantum dots which are the most widely used probes. Proteins, organelles, nucleotides and other chemicals related to cell biology may all be potential targets. We also discussed the advantages and disadvantages of different probes. Although specific probes in LCI still need to be explored, the application of LCI may be attractive for better understanding of cellular functions.

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Gold nanoshell bioconjugates for molecular imaging in living cells

Cited by 291 publications

References 15 publications

Biomedical Applications of Plasmon Resonant Metal Nanoparticles

Biomedical Applications of Plasmon Resonant Metal Nanoparticles

Symmetry breaking in individual plasmonic nanoparticles

Application of Probes in Live Cell Imaging~!2010-01-03~!2010-05-09~!2010-08-16~!

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