Gold nanorods: Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions

Alkilany, Alaaldin M.; Thompson, L. J.; Boulos, Stefano P.; Sisco, Patrick N.; Murphy, Catherine J.

doi:10.1016/j.addr.2011.03.005

Cited by 737 publications

(595 citation statements)

References 116 publications

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“…One recent Au-NR application being explored is the targeted ablation of cancer cells through photothermal therapy [7]. This process is being enhanced through the addition of targeting agents and chemotherapy treatments to the Au-NR surface [8,9].…”

Section: Introductionmentioning

confidence: 99%

Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics

Comfort¹,

Speltz²,

Stacy³

et al. 2013

ANP

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Investigations into the use of gold nanorods (Au-NRs) for biological applications are growing exponentially due to their distinctive physicochemical properties, which make them advantageous over other nanomaterials. Au-NRs are particularly renowned for their plasmonic characteristics, which generate a robust photothermal response when stimulated with light at a wavelength matching their surface plasmon resonance. Numerous reports have explored this nanophotonic phenomenon for temperature driven therapies; however, to date there is a significant knowledge gap pertaining to the kinetic heating profile of Au-NRs within a controlled physiological setting. In the present study, the impact of environmental composition on Au-NR behavior and degree of laser actuated thermal production was assessed. Through acellular evaluation, we identified a loss of photothermal efficiency in biologically relevant fluids and linked this response to excessive particle aggregation and an altered Au-NR spectral profile. Furthermore, to evaluate the potential impact of solution composition on the efficacy of nano-based biological applications, the degree of targeted cellular destruction was ascertained in vitro and was found to be susceptible to fluid-dependent modifications. In summary, this study identified a diminution of Au-NR nanophotonic response in artificial physiological fluids that translated to a loss of application efficiency, pinpointing a critical concern that must be considered to advance in vivo, nano-based bio-applications.

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Section: Introductionmentioning

confidence: 99%

Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics

Comfort¹,

Speltz²,

Stacy³

et al. 2013

ANP

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“…Isso ocorre devido à redução dos íons Ag + a Ag 0 que ocorre na presença de outros metais (como o ouro) e posterior deposição lenta nas faces em que houve alongamento, limitando o comprimento dos bastões a aproximadamente 100 nm. 14,41 Ao final das etapas da síntese os alunos observaram que a solução resultante apresentou uma coloração arroxeada, e desta solução foi separada uma alíquota para a análise espectroscópica na região UV-Vis-NIR (Figura 1A). Além disso, quando disponível, os alunos podem realizar imagem por microscopia eletrônica de transmissão (TEM) para visualização do material sintetizado (Figura 1B).…”

Section: Resultados E Discussão Síntese De Nanobastões De Ourounclassified

Uso de nanobastões de ouro para o desenvolvimento de aulas práticas de nanotecnologia

Ferreira¹,

Ladeira²,

Leite³

et al. 2017

Quim. Nova

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. A gold nanoparticles functionalization experiment was conducted in a biotechnology summer course at UFOP as a model for the introduction of the laboratory practice in nanotechnology for postgraduate courses in the areas of chemistry and biotechnology. The gold nanorods were synthesized by the seed method and then, functionalized with anti-IL-6 antibodies using the reagents EDAC/NHS and polyethyleneimine (PEI). This nanocompound was tested against the binding with the specific antigen (IL-6) and changes in the longitudinal plasmon absorption spectrum showed the coupling efficiency, which was also verified by the decrease in zeta potential. The experiment was satisfactory, with a positive feedback from participants, and could be implemented in nanotechnology practical classes from postgraduate courses, as a way for improve education in the emergent area of nanobiotechnology.Keywords: gold nanorods; surface plasmon resonance; nanotechnology experiment. INTRODUÇÃOO universo da nanotecnologia se expandiu consideravelmente na esfera da pesquisa científica em todo mundo nos últimos anos e constitui uma área que certamente acarretará em enormes retornos econômicos. Materiais e tecnologias em escala nanométrica têm sido empregados em diversas áreas, tais como no setor alimentício, sistemas de energia renovável, bioinformática e na medicina. 1-4 Além disso, constituem matéria-prima nobre para o desenvolvimento de dispositivos e sistemas multifuncionais que se adequam aos mais variados produtos e processos industriais.Perante a complexidade e relevância da nanotecnologia, emerge a necessidade de abordagens práticas e sistêmicas nos cursos de graduação e também de pós-graduação. Entretanto, apesar de já desenvolvidos e utilizados há algum tempo em pesquisas de diversas áreas, os conceitos da nanotecnologia ainda não são abordados em muitos cursos teóricos e práticos de pós-graduação no Brasil.Neste contexto, uma classe de nanomateriais de grande potencial tecnológico e educacional são as nanopartículas de ouro (AuNPs), que possuem propriedades ópticas, magnéticas e estruturais interessantes para aplicações químicas e biológicas. São ainda as nanopartículas metálicas mais estáveis que se tem conhecimento. 5,6 Elas podem ser sintetizadas em diversos tamanhos e formatos, tais como nanoesferas, nanobastões, nanogaiolas, nanoestrelas e nanoconchas. 5 A síntese das AuNPs geralmente é econômica, pois embora demande reagentes onerosos, estes são empregados em concentrações muito baixas. 7 Entre as várias aplicações das nanopartículas de ouro, o sensoriamento é tido como uma das áreas de maior interesse na atualidade. Nesse contexto, dentre as diferentes formas de nanopartículas, é dada grande atenção às nanoesferas e nanobastões de ouro. Isso se deve ao grande volume de conhecimento obtido sobre a característica mais peculiar das nanopartículas de ouro, a chamada ressonância plasmônica de superfície (SPR). A SPR se caracteriza pela oscilação coletiva dos elétrons de condução das partículas metálicas desencadeada pela exposição à ...

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“…This optical property can be well explained by Gans theory [4]. Due to minimal NIR light absorption by most human tissues and water in the NIR (700-1300 nm), GNRs exhibiting strong NIR absorption and scattering are very attractive for in vivo biomedical imaging and drug delivery and therapy applications [5].…”

Section: Optical Properties Of Gnrsmentioning

confidence: 99%

Applications of gold nanorods in biomedical imaging and related fields

Hong-xing

Liu

et al. 2013

Chin. Sci. Bull.

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Gold nanorods (GNRs) have great potential widespread applications in biomedical imaging, drug delivery and photothermal therapy due to unique surface plasmon resonance (SPR) ranging from visible to near infrared (NIR) region, facile synthesis and easy functionalization. In this review, the recent progress of GNRs in bioimaging, drug delivery, photothermal therapy and theranostics is summarized and the recommendations for the future work on GNRs are also covered.

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Gold nanorods: Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions

Cited by 737 publications

References 116 publications

Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics

Physiological Fluid Specific Agglomeration Patterns Diminish Gold Nanorod Photothermal Characteristics

Uso de nanobastões de ouro para o desenvolvimento de aulas práticas de nanotecnologia

Applications of gold nanorods in biomedical imaging and related fields

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