Gold nanorods@mSiO2 with a smart polymer shell responsive to heat/near-infrared light for chemo-photothermal therapy

Abstract

Novel composite nanoparticles based on poly(N-isopropylacrylamide-co-N-hydroxymethyl acrylamide) (P(NIPAM-co-NHMA)) layer coated gold nanorod@mesoporous silica (GNR@mSiO 2 ) has been successfully synthesized by precipitation polymerization. The composite nanoparticles exhibited a thermo/near-infrared (NIR) light sensitivity. The volume phase transition temperature (VPTT) could be precisely regulated by the content of NHMA in monomers and an excellent photothermal conversion effect was expressed due to the surface plasmon resonance of gold nanorods in the composite nanoparticles. Doxorubicin hydrochloride (DOX) was applied as a model drug and the drug storage/release behavior was investigated. The results demonstrated that DOX could be effectively loaded into the composite nanoparticles with 21% loading capacity. The cumulative release of DOX-loaded composite nanoparticles was temperature dependent and the release rate was significantly enhanced above the VPTT. Therefore, the composite nanoparticles applied as a drug delivery system could reduce the side effect of DOX to normal tissues as only a small fraction of DOX was released from the composite nanoparticles at 37 C. In addition, the DOX-loaded composite nanoparticles demonstrated a synergistic effect, the therapeutic efficacy was improved significantly by the combination of photothermal therapy and traditional chemotherapy with low composite nanoparticle concentration and short laser irradiation time in an in vitro study.

Facile synthesis of gold/polymer nanocomposite particles using polymeric amine-based particles as dual reductants and templates

“…The combined chemical and physical properties of the gold/polymer composite particles have opened up many potential applications in various emerging fields including sensing [1,2], biomedicine [3,4], and catalysis [5]. The gold/polymer composite particles can be synthesized using different types of polymers such as homopolymer [6], block copolymers [7e9], and colloidal particles [10e14].…”

Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and magnetic resonance cell imaging

“…[25][26][27] Diagnostic and therapeutic agents are physically entrapped or conjugated to the nanocarriers, or they are conjugated to carefully designed polymers, which subsequently form nanocarriers. 28,29 In the present study, PEI-modified core/shell nanoparticles of Fe 3 O 4 @SiO 2 were fabricated, which could electrostatically absorb VEGF small hairpin (sh)RNA. The Fe 3 O 4 @SiO 2 /VEGF shRNA nanocomposites showed low cytotoxicity and good hemocompatibility, and they could be easily internalized by MCF-7 cells; they also exhibited significant inhibition of VEGF gene expression.…”

Synthesis of Mesoporous Silica/Reduced Graphene Oxide Sandwich-Like Sheets with Enlarged and “Funneling” Mesochannels

“…15,[64][65][66] In the bottom aqueous solution, silicate oligomers and CTAC molecules could co-assemble into micelles, then nucleating on the surface of GO nanosheets (Scheme 1b, c). 17,[55][56][57][58][59] Remaining silicate oligomers in aqueous solution would be further bound to the micelles and polymerized in the gap between neighboring micelles and GO sheets to form pore walls (Scheme 1c, d). 17,[55][56][57][58][59]61 As the reaction continues, the GO/surfactant/inorganic species could get in touch with the hemiemulsion micelles repeatedly, resulting in the formation of "funneling" mesochannels owing to the pore-expanding effect of organic solvent (Scheme 1d, e).…”