Gold Nanorods as Plasmonic Sensors for Particle Diffusion

Wulf, Verena; Knoch, Fabian; Speck, Thomas; Sönnichsen, Carsten

doi:10.1021/acs.jpclett.6b02165

Cited by 24 publications

(34 citation statements)

References 31 publications

(39 reference statements)

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“…Another context where GNRs have received interest is sensing of biological agents and toxic compounds for e.g. biomedical diagnostics, forensic analysis and environmental monitoring [ 33 – 37 ]. In particular, various examples of biosensors have been reported, where GNRs served to detect an analyte by changing colour in a suspension upon aggregation or by enhancing Raman signals [ 37 – 41 ].…”

Section: Introductionmentioning

confidence: 99%

Ready-to-use protein G-conjugated gold nanorods for biosensing and biomedical applications

et al. 2018

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BackgroundGold nanorods (GNRs) display unique capacity to absorb and scatter near infrared light, which arises from their peculiar composition of surface plasmon resonances. For this reason, GNRs have become an innovative material of great hope in nanomedicine, in particular for imaging and therapy of cancer, as well as in photonic sensing of biological agents and toxic compounds for e.g. biomedical diagnostics, forensic analysis and environmental monitoring. As the use of GNRs is becoming more and more popular, in all these contexts, there is emerging a latent need for simple and versatile protocols for their modification with targeting units that may convey high specificity for any analyte of interest of an end-user.ResultsWe introduce protein G-coated GNRs as a versatile solution for the oriented immobilization of antibodies in a single step of mixing. We assess this strategy against more standard covalent binding of antibodies, in terms of biocompatibility and efficiency of molecular recognition in buffer, serum and plasma, in the context of the development of a direct immunoenzymatic assay. In both cases, we estimate an average of around 30 events of molecular recognition per particle. In addition, we disclose a convenient protocol to store these particles for months in a freezer, without any detrimental effect.ConclusionsThe biocompatibility and efficiency of molecular recognition is similar in either case of GNRs that are modified with antibodies by covalent binding or oriented immobilization through protein G. However, protein G-coated GNRs are most attractive for an end-user, owing to their unique versatility and ease of bioconjugation with antibodies of her/his choice.Electronic supplementary materialThe online version of this article (10.1186/s12951-017-0329-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Ready-to-use protein G-conjugated gold nanorods for biosensing and biomedical applications

et al. 2018

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“…In turn, surface plasmon resonance causes a strong absorption of the incident light, and a portion of this energy is dissipated as local heat, along with the release of molecules from the AuNP surface. Due to these properties, AuNPs are applied in nanomedicine for detection, using techniques such as surface-enhanced Raman spectroscopy [ 35 ] or surface-enhanced fluorescence [ 36 ]; as plasmonic sensors [ 37 ]; for drug transport and release [ 38 – 40 ]; or in photothermal treatments [ 41 – 43 ].…”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles stabilized with βcyclodextrin-2-amino-4-(4-chlorophenyl)thiazole complex: A novel system for drug transport

et al. 2017

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While 2-amino-4-(4-chlorophenyl)thiazole (AT) drug and thiazole derivatives have several biological applications, these compounds present some drawbacks, such as low aqueous solubility and instability. A new complex of βCD-AT has been synthesized to increase AT solubility and has been used as a substrate for the deposit of solid-state AuNPs via magnetron sputtering, thus forming the βCD-AT-AuNPs ternary system, which is stable in solution. Complex formation has been confirmed through powder X-ray diffraction and 1D and 2D nuclear magnetic resonance. Importantly, the amine and sulfide groups of AT remained exposed and can interact with the surfaces of the AuNPs. The complex association constant (970 M-1) has been determined using phase solubility analysis. AuNPs formation (32 nm average diameter) has been studied by UV-Visible spectroscopy, transmission/scanning electron microscopy and energy-dispersive X-ray analysis. The in vitro permeability assays show that effective permeability of AT increased using βCD. In contrast, the ternary system did not have the capacity to diffuse through the membrane. Nevertheless, the antibacterial assays have demonstrated that AT is transferred from βCD-AT-AuNPs, being available to exert its antibacterial activity. In conclusion, this novel βCD-AT-AuNPs ternary system is a promising alternative to improve the delivery of AT drugs in therapy.

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“…This value is about an order of magnitude larger than a previously reported result of 19.9 kJ/mol for a PMMA/PS binary film, and 14.4 kJ/mol for 16.5 nm Au nanoparticles in water 116. This is expected because the diffusion constant depends greatly on the size of the diffusing material 117,118.…”

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confidence: 56%

Utilizing Hybrid Plasmon Modes to Probe Nanoparticle-Polymer Interfaces

Bushell¹

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Nanoparticle-polymer composite materials have widespread applications in fields such as: sensing, electronics, and biology, due to their desirable physical properties. However, many fabrication techniques render little control over nanoparticle incorporation, and homogeneity of the resulting material. This thesis focuses on the thermally induced embedding of silver nanocubes (AgNCs) into polymer surfaces. The AgNCs were deposited onto polymer films, through a Langmuir approach, which allows fine control over nanoparticle density in the monolayer. The AgNC monolayer was then heated above the glass transition temperature of the polymer, which facilitates the irreversible incorporation of the AgNCs. Embedding of the AgNCs were monitored in real-time, through spatially separated hybrid plasmonic resonances supported by the AgNCs when deposited onto the polymer film, which allowed the determination of a surface layer on top of the bulk polymer with enhanced mobility as well as diffusion constants for the embedding process.ii Preface This preface provides full bibliographical details for each article included whether the article is reproduced in whole or in part.

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Gold Nanorods as Plasmonic Sensors for Particle Diffusion

Cited by 24 publications

References 31 publications

Ready-to-use protein G-conjugated gold nanorods for biosensing and biomedical applications

Ready-to-use protein G-conjugated gold nanorods for biosensing and biomedical applications

Gold nanoparticles stabilized with βcyclodextrin-2-amino-4-(4-chlorophenyl)thiazole complex: A novel system for drug transport

Utilizing Hybrid Plasmon Modes to Probe Nanoparticle-Polymer Interfaces

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