Gold-nanorod enhances dielectric voltammetry detection of c-reactive protein: A predictive strategy for cardiac failure

Letchumanan, Iswary; Arshad, M. K. Md; Balakrishnan, Sharma Rao; Gopinath, Subash C. B.

doi:10.1016/j.bios.2019.01.042

Cited by 85 publications

(59 citation statements)

References 27 publications

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“…These antibody or GNS antibody-modified surfaces were used to detect the SCC-Ag and compared. The GNS antibody-immobilized TiO 2 surface was analysed by atomic force microscopy (AFM), field-emission transmission electron microscopy (FETEM) and energy dispersive X-ray (EDX) analyser as described earlier [15]. AFM observations were at 5 μm scale, whereas SEM was at 100 nM scale operated with 15 kV.…”

Section: Immobilization On Gns Antibody On Tio 2 -Ide Surfacementioning

confidence: 99%

“…Nanomaterials are smaller in size, have larger surface area, have good thermal and electrical conductivity, are compatible with biomolecules, and show a tremendous capability to be applied in the field of biosensor [13,14]. Nanomaterial has been applied in two different ways for purposes: one is surface functionalization and another is conjugating the analyte or target in order to improve the detection [15]. Gold is one of the well-established nanomaterials and applied in various sensors, which include surface plasmon resonance, waveguide-mode sensor, electrochemical sensor and colorimetry [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Nanodetection of Head and Neck Cancer on Titanium Oxide Sensing Surface

Wang

Guo

et al. 2020

Nanoscale Res Lett

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Head and neck cancer is a heterogeneous disease, originating in the squamous cells lining the larynx (voice box), mouth, pharynx (throat), nasal cavity and salivary glands. Head and neck cancer diagnosis at the later stage is greatly influencing the survival rate of the patient. It makes a mandatory situation to identify this cancer at the earlier stages of development with a suitable biomarker. Squamous cell carcinoma antigen (SCC-Ag) is a circulating serum tumour biomarker, and the elevated level has been found in the head and neck cancer patients and highly correlated with the tumour volume. The present research was carried out to detect and quantify the level of SCC-Ag on titanium oxide (TiO 2 )-modified interdigitated electrode sensor (IDE) by SCC-Ag antibody. The detection of SCC-Ag was found at the level of 100 fM, while it was improved to 10 fM when the antibody was conjugated with gold nanostar, representing a 10-fold improvement. Interestingly, this enhancement in sensitivity is 1000-folds higher than other substrates. Moreover, the specificity analysis was carried out using two different control proteins and noticed that the antibody only recognised SCC-Ag, indicating the specific detection on IDE-TiO 2 sensing surface.

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Section: Immobilization On Gns Antibody On Tio 2 -Ide Surfacementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanodetection of Head and Neck Cancer on Titanium Oxide Sensing Surface

Wang

Guo

et al. 2020

Nanoscale Res Lett

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“…e application of nanomaterials in the field of biosensors has improved the detection of biomolecules and reduced the detection limit [14,15]. Different nanoparticles such as gold, silver, graphene, silica, and copper nanoparticles have been synthesized and used for various kinds of medical applications [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Coordination of Nanoconjugation with an Antigen/Antibody for Efficient Detection of Gynecological Tumors

Liu

Yang

Shao

et al. 2020

Journal of Analytical Methods in Chemistry

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Cervical, ovarian, and endometrial cancers are common in the female reproductive system. Cervical cancer starts from the cervix, while ovarian cancer develops when abnormal cells grow in the ovary. Endometrial or uterine cancer starts from the lining of the womb in the endometrium. Approximately 12,000 women are affected every year by cervical cancer in the United States. Squamous cell carcinoma antigen (SCC-Ag) is a well-established biomarker in serum for diagnosing gynecological cancers, and its levels were observed to be elevated in cervical, ovarian, and endometrial cancer patients. Moreover, SCC-Ag was used to identify the tumor size and progression stages. Various biosensing systems have been proposed to identify SCC-Ag; herein, enhanced interdigitated electrode sensing is presented with the use of gold nanoparticles (GNPs) to conjugate an antigen/antibody. It was proved that the limit of detection is 62.5 fM in the case of antibody-GNP, which is 2-fold higher than that by SCC-Ag-GNP. Furthermore, the antibody-GNP-modified surface displays greater current increases with concomitant dose-dependent SCC-Ag levels. High analytical performance was shown by the discrimination against α-fetoprotein and CYFRA 21-1 at 1 pM. An enhanced sensing system is established for gynecological tumors, representing an advance from the earlier detection methods.

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“…Various metallic nanoparticles such as, platinum, silver, and gold were focused recently because of their requisite importance [23,24]. Among the previously mentioned metal nanoparticles, gold nanoparticle (GNP) is more vital because of its history in medicinal application, e.g., treatment of cancer and arthritis with conjugated GNP and also due to their biocompatibility [25][26][27][28][29]. In this research, GNP was purchased, and compounds of A. paniculata herbal plant leaf were captured on the GNP.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Potential of Andrographis paniculata Conjugated Gold Nanoparticle

Razalli¹,

Gopinath²,

Kasim³

et al. 2019

INNOCS Theranos Pharmco Sci

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Background: Herbal extracts have been traditionally used as antibacterial agents, and different strategies have been proposed to enhance their antimicrobial activities. This research aimed to assess the antimicrobial potential of Andrographis paniculata conjugated gold nanoparticle (GNP) compounds against Escherichia coli and Bacillus subtilis.Methods: Herbal extract was conjugated with GNP through electrostatic interaction, and characterization was carried out by Fourier-transmission infrared spectroscopy, screening electron microscopy, and transmission electron microscopy and supported by energy-dispersive X-ray spectroscopy. Antibacterial activity of the herbal extract and GNP conjugation was evaluated by disc diffusion assay.Results: Chemical and morphological characterizations of the GNP and herbal extract conjugate revealed intactness of the GNP. In disc diffusion assay, the inhibition zone formed by these compounds was measured for both microorganisms, and they were in the range of 0.6-0.9 cm for the herbal extract. When the herbal extract conjugated with GNP, the zone was between 0.8 and 1.1 cm.Conclusion: This study demonstrated the potentiality of GNP to carry the antibacterial compounds from the herbal extract.

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Gold-nanorod enhances dielectric voltammetry detection of c-reactive protein: A predictive strategy for cardiac failure

Cited by 85 publications

References 27 publications

Nanodetection of Head and Neck Cancer on Titanium Oxide Sensing Surface

Nanodetection of Head and Neck Cancer on Titanium Oxide Sensing Surface

Coordination of Nanoconjugation with an Antigen/Antibody for Efficient Detection of Gynecological Tumors

Antimicrobial Potential of Andrographis paniculata Conjugated Gold Nanoparticle

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