Gold nanorod-based localized surface plasmon resonance biosensor for sensitive detection of hepatitis B virus in buffer, blood serum and plasma

Wang, Xiaohui; Li, Yuan; Wang, Huafen; Fu, Qiuxia; Peng, Jianchun; Wang, Yingli; Du, Juan; Zhou, Yong Jin; Li, Zhan

doi:10.1016/j.bios.2010.07.121

Cited by 200 publications

(116 citation statements)

References 37 publications

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“…Recent advances in virus biosensing have been made, especially in fluorescence, 65 light scattering, 66,67 surface-enhanced Raman scattering (SERS), 68,69 electrochemical, 7,34,70 QCM, 71,72 microcantilevers (MCLs), 73,74 and SPR 17,47 sensors. The breakdown structure of "nanobiosensor for viral detection" segmentation is described in Figure 2.…”

Section: Detection Methods Of Virus Biosensorsmentioning

confidence: 99%

“…157 An electrical field applied to the QCM produces mechanical stress that induces an acoustic wave to travel in a direction perpendicular to the surface of the crystal. 66 QCM is a rapid, easy to use, and relatively simple method that can be applied in real-time detection of mass changes on the crystal surface, such as hybridization and/or antigenantibody reactions. 146,158 Receptors for viral target substances (probes, antibodies) are capable of binding to the terminal active functional groups of SAMs and capturing targets.…”

mentioning

confidence: 99%

“…159,160 The QCM can consequently detect mass changes due to these molecular interactions on the surface of the QCM. 66 During the last decade, a new approach in the form of functionalized nanoparticles has been exploited to increase the specificity and sensitivity of QCM biosensors. 161 QCM biosensing can be applied in various fields of biotechnology, such as clinical diagnosis 159,162 and detection of the occurrence of epidemiologically important diseases.…”

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confidence: 99%

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Nanoscale virus biosensors: state of the art

Krejčová¹,

Michálek²,

Rodrigo³

et al. 2015

NDD

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Abstract:Since the beginning of the new millennium, viruses have shown huge epidemiological and pandemic potential: severe acute respiratory syndrome (SARS) in 2002, pandemic swine flu in 2009, and last but not least the West African Ebola outbreak in 2014. The occurrence and spread of the new virus in pandemic dimension poses a threat to the health and lives of 7 billion people worldwide. There is a growing urgency for highly sensitive and selective detection techniques, usable for a wide number of applications, including disease diagnosis, pharmaceutical research, agriculture, as well as preventive measures. Nanobiosensors represent a new promising tool for virus detection. This review gives a brief survey of the issue of viral detection, comprising diagnostics of target structure of viruses such as nucleic acids or proteins. This review covers different detection principles, methods of fabrication, and applications of virus biosensors.

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Section: Detection Methods Of Virus Biosensorsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Nanoscale virus biosensors: state of the art

Krejčová¹,

Michálek²,

Rodrigo³

et al. 2015

NDD

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“…59 GNRs (with a length of 68±8 nm and a width of 30±5 nm) were modified by monoclonal hepatitis B surface antibody (HbsAb) via physical adsorption. Upon incubation with HbsAg, a red shift of the longitudinal band was observed due to the binding events.…”

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confidence: 99%

Nanoplasmonic biosensors: current perspectives

Shukla¹,

Mukherji

2015

NDD

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Recent advances in nanotechnology and nanofabrication have helped develop a wide variety of nanostructured platforms for use as nanoplasmonic biosensors. These can either be in solution phase or be confined on a substrate in the form of metallic nanofilms or periodic arrays. Plasmonic properties of these nanostructures depend on the size, shape, position, orientation, etc, and can be altered by interaction between probe and target species on the metal surfaces. This property of nanostructures has been exploited in refractometric nanoplasmonic biosensors, surface-enhanced Raman spectroscopy-based biosensors, plasmon-enhanced fluorescence biosensors, etc. These nanoplasmonic biosensors are employed in diverse areas such as clinical diagnosis, biosecurity, food, and environmental monitoring. Among these, clinical diagnosis has attracted the most research and commercial interest. Nanoplasmonic biosensors can detect disease biomarkers using highly specific and selective biological recognition elements on the nanostructured surfaces. Many excellent reviews exist in this area that trace the developments over the past 3 decades. This review focuses on some of the more recent studies on the detection of various disease biomarkers through nanoplasmonic biosensors. In the process, we have described fabrication techniques and biofunctionalization of such biosensors.

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“…LSPR sensors can be explored as fast, reliable, low-cost, and fairly simple tool for medical diagnosis. Various examples of LSPR biosensors were attributed to the diagnosis of relevant medical disease, as Alzheimer [14], preeclampsia [15], influenza [16], HIV-1 [17], hepatitis B infections [18] and Dengue virus [19], as well as for intracellular protein sensing [20].…”

Section: Introductionmentioning

confidence: 99%

Engineering a Localized Surface Plasmon Resonance Platform for Molecular Biosensing

Farooq¹,

Araujo²

2018

OJAppS

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In this work, we introduce a new perspective on the development of Localized Surface Plasmon Resonance (LSPR) optical biosensors. Computational simulations, focused on the assessment of the LSPR spectrum and spatial distribution of the electromagnetic field enhancement near a metallic nanoparticle, elucidated the behavior of crucial parameters, as figure of merit, bulk and molecular sensitivity, which governs a LSPR sensor performance. Gold and silver nanospheres were explored as starting point to assess plasmonic optical characteristics of the nanostructured sensor platform. Here, for the first time in the literature, Campbell's model was evaluated exploiting a NP size-dependence approach. The theoretical analyses indicate a nonlinear behavior of the bulk and molecular sensitivity as function of the NP size. Substantial LSPR peak shifts due to the adsorption of molecules layer on a NP surface were observed for nanoparticles with ~5 nm and ~40 nm radius. Moreover, on molecular sensing, LSPR peak shift is also determined by the thickness of adsorbed molecular shell layers. We observed that for 40 nm radius gold and silver nanospheres, significant LSPR peak shift could be induced by small (few nm) thickness change of the adsorbate shell layer. Moreover, this work provides insights on the LSPR behavior due to adsorption of molecular layer on a NP surface, establishing a new paradigm on engineering LSPR biosensor. Furthermore, the proposed approach can be extended to engineer an efficiently use of different nanostructures on molecular sensing.

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Gold nanorod-based localized surface plasmon resonance biosensor for sensitive detection of hepatitis B virus in buffer, blood serum and plasma

Cited by 200 publications

References 37 publications

Nanoscale virus biosensors: state of the art

Nanoscale virus biosensors: state of the art

Nanoplasmonic biosensors: current perspectives

Engineering a Localized Surface Plasmon Resonance Platform for Molecular Biosensing

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