Gold nanoring core-shell satellites with abundant built-in hotspots and great analyte penetration: An immunoassay platform for the SERS/fluorescence-based detection of carcinoembryonic antigen

Electrochemistry/Photoelectrochemistry-Based Immunosensing and Aptasensing of Carcinoembryonic Antigen

“…Compared with the single signal-based detection mode, the detection limit from ratiometric analysis was much lower than that using ∆I TB or ∆I Cu 2 S−CuS as a respective current response. Furthermore, the application of a dual-responsive assay is another strategy to obtain accurate and persuasive detection results by the simultaneous signal outputs from two types of sensing platforms [54,55]. Using electrochemistry-fluorescence dual-responsive methods, the ingenious integration of sensitive electrochemical and stable fluorescent readouts has attracted tremendous interest in recent years.…”

SERS-Active Composites with Au–Ag Janus Nanoparticles/Perovskite in Immunoassays for Staphylococcus aureus Enterotoxins

“…However, the detection time was long, and the pathogenic bacteria were lethal in the process of processing and could not be detected. Besides, several electrochemical biosensors, chemiluminescence assay, surface-enhanced Raman scattering (SERS) assay, and fluorescence assay were also developed to detect SEs. − Alternatively, SERS biosensors possessed high sensitivity down to single-molecule detection and showed potential for application in biological molecule analysis, − environmental monitoring, , and disease diagnosis, − and would be a promising tool for reliable SE detection. However, there were still some issues to be solved for SERS signal-dependent sensitive and accurate SE detection: (1) the high and non-interference SERS signals for ultrasensitive and precise detection; (2) the uniform position of Raman labels on the surface of SERS for the production of reproducible SERS signals.…”

A label-free fluorescent aptasensor based on the AIE effect and CoOOH for ultrasensitive determination of carcinoembryonic antigen

“…So far, a lot of methods such as colorimetry, 6 surface-enhanced Raman scattering, 7,8 enzyme-linked immunosorbent assay, 9 radioimmunoassay, 10 fluorescence analysis, 11 surface plasmon resonance method, 12 chemiluminescence method, 13 and electrochemical analysis 14,15 have been used to detect CEA. Most of these methods were based on immune response detection based on antigen/antibody interaction.…”