Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery

Prabaharan, M.; Grailer, Jamison; Pilla, Srikanth; Steeber, Douglas A.; Gong, Shaoqin

doi:10.1016/j.biomaterials.2009.07.048

Cited by 337 publications

(237 citation statements)

References 30 publications

Supporting

Mentioning

227

Contrasting

Unclassified

Order By: Relevance

“…It was indicated that more DOX was uptaken by cells with the help of SWNTs modified with hydrazone bond. This result implied that a delivery system comprising hydrazone linkage between DOX molecules and SWNTs results in more efficient DOX release from lysosomes 28,36 which then moves to the nucleus.…”

Section: Intracellular Dox From Swnt-dox and Swnt-hba-dox Conjugatesmentioning

confidence: 99%

“…Hydrazones, formed by condensation of the C-13 ketone of DOX with a hydrazine, have been used for attaching drugs to polymers [24][25][26] and nanoparticles. 27,28 However, there is no report on the covalent immobilization of anticancer drug onto the surfaces of functionalized SWNTs through hydrazone linkage. Presented herein is the preparation of the SWNT-hydrazone-DOX delivery system, in which the antitumor agent DOX was covalently linked to SWNTs through biocleavable hydrazone linkage.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development and evaluation of pH-responsive single-walled carbon nanotube-doxorubicin complexes in cancer cells

Gu¹,

Cheng²,

Jin³

et al. 2011

IJN

View full text Add to dashboard Cite

Single-walled carbon nanotubes (SWNTs) have been identified as an efficient drug carrier. Here a controlled drug-delivery system based on SWNTs coated with doxorubicin (DOX) through hydrazone bonds was developed, because the hydrazone bond is more sensitive to tumor microenvironments than other covalent linkers. The SWNTs were firstly stabilized with polyethylene glycol (H 2 N-PEG-NH 2 ). Hydrazinobenzoic acid (HBA) was then covalently attached on SWNTs via carbodiimide-activated coupling reaction to form hydrazine-modified SWNTs. The anticancer drug DOX was conjugated to the HBA segments of SWNT using hydrazine as the linker. The resulting hydrazone bonds formed between the DOX molecules and the HBA segments of SWNTs are acid cleavable, thereby providing a strong pH-responsive drug release, which may facilitate effective DOX release near the acidic tumor microenvironment and thus reduce its overall systemic toxicity. The DOX-loaded SWNTs were efficiently taken up by HepG2 tumor cells, and DOX was released intracellularly, as revealed by MTT assay and confocal microscope observations. Compared with SWNT-DOX conjugate formed by supramolecular interaction, the SWNT-HBA-DOX featured high weight loading and prolonged release of DOX, and thus improved its cytotoxicity against cancer cells. This study suggests that while SWNTs have great potential as a drug carrier, the efficient formulation strategy requires further study.

show abstract

Section: Intracellular Dox From Swnt-dox and Swnt-hba-dox Conjugatesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and evaluation of pH-responsive single-walled carbon nanotube-doxorubicin complexes in cancer cells

Gu¹,

Cheng²,

Jin³

et al. 2011

IJN

View full text Add to dashboard Cite

show abstract

“…[7] It was because the anticancer drug would attack the healthy cells as well as the cancer cells. Hence, improving the drug targeting property would decrease the side effect.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of FA conjuagted MPEG-PLA polymer nanoparticles loaded with 10-hydroxycamptothecin for sustained drug release

Liu¹,

Yang²,

Yang³

et al. 2016

Proceedings of the 2016 6th International Conference on Machinery, Materials, Environment, Biotechnology and Computer

View full text Add to dashboard Cite

“…[1][2][3][4] Some synthetic routes have been exploited to synthesize amphiphilic block copolymers, including living anionic polymerization, 5-7 cationic polymerization, [8][9][10] and the controlled/ ''living'' radical polymerization and so forth. [11][12][13] Among these methods reported, living radical polymerization (LRP), which exemplifies stable free radical polymerization (SFRP), 14,15 atom transfer radical polymerization (ATRP), [16][17][18] and reversible addition-fragmentation transfer polymerization (RAFT), [19][20][21] has become preferred to others lying in its accurate control of molecular weight, polydispersity, and chain-end functionality.…”

Section: Introductionmentioning

confidence: 99%

“…In fact, the linear pentablock copolymers comprised of PSt, PEO, and PCL have been reported. 41 Nevertheless, no reports have been published on their analogous synthesis of H-shaped block copolymers (PSt) 2 …”

Section: Introductionmentioning

confidence: 99%

Chemoenzymatic Synthesis of H-shaped Amphiphilic Pentablock Copolymer and Its Self-assembly Behavior

Chen¹,

Li²,

Li³

et al. 2013

Polymer Korea

View full text Add to dashboard Cite

H-shaped amphiphilic pentablock copolymers (PSt) 2 -b-PCL-b-PEO-b-PCL-b-(PSt) 2 was synthesized via chemoenzymatic method by combining enzyme-catalyzed ring-opening polymerization (eROP) of ε-caprolactone (ε-CL) and atom transfer radical polymerization (ATRP) of styrene. By this process, we obtained copolymers with controlled molecular weight and low polydispersity. The structure and composition of the obtained copolymers were characterized by nuclear magnetic resonance (NMR), gel permeation chromatography (GPC) and infrared spectroscopy analysis (IR). The crystallization behavior of the copolymers was analyzed by differential scanning calorimetry (DSC) and X-ray diffraction (XRD). The crystallization behavior of the H-shaped block copolymers demonstrated a PCL dominate crystallization. The self-assembly behavior of the copolymers was investigated in aqueous media. The hydrodynamic diameters of the copolymer micelles in aqueous solution were measured by dynamic light scattering (DLS). The morphology of the copolymer micelles was observed by atomic force microscopy (AFM) and transmission electron microscopy (TEM). The hydrodynamic diameters of spherical micelles declined gradually with the increase of the hydrophobic chain lengths of the copolymers. The critical micelle concentration (CMC) values were determined from fluorescence emission, and it was found that the CMCs decreased with an increase of PSt hydrophobic block lengths.

show abstract

Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery

Cited by 337 publications

References 30 publications

Development and evaluation of pH-responsive single-walled carbon nanotube-doxorubicin complexes in cancer cells

Development and evaluation of pH-responsive single-walled carbon nanotube-doxorubicin complexes in cancer cells

Preparation and characterization of FA conjuagted MPEG-PLA polymer nanoparticles loaded with 10-hydroxycamptothecin for sustained drug release

Chemoenzymatic Synthesis of H-shaped Amphiphilic Pentablock Copolymer and Its Self-assembly Behavior

Contact Info

Product

Resources

About