Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy

Heo, Dong Nyoung; Yang, Dae Hyeok; Moon, Hojin; Lee, Jung Bok; Bae, Min Soo; Lee, Sang Cheon; Lee, Wonjun; Sun, In Cheol; Kwon, Il Keun

doi:10.1016/j.biomaterials.2011.09.064

Cited by 322 publications

(185 citation statements)

References 29 publications

Supporting

Mentioning

177

Contrasting

Unclassified

Order By: Relevance

“…[24] Some nanoparticle drug carriers functionalised with Taxol have been investigated for biomedical applications. [25,26] However, Taxol has a low therapeutic index, and non-specific release to targeted cancerous cells that causes severe side effects has been observed. These hurdles have limited its potential use in clinical applications.…”

Section: Introductionmentioning

confidence: 99%

“…These hurdles have limited its potential use in clinical applications. [25,26] Some drug carriers, though not suited as TDDs, have been approved. For example, nanoparticles-albumin conjugated to Taxol exhibited enhancement in treating metastatic breast cancer in a clinical trial.…”

Section: Introductionmentioning

confidence: 99%

“…PEGylation involves the use of PEG molecules alone or conjugated to other biomolecules, such as biotin, peptides, oligonucleotides, or drugs to coat the gold nanoparticles or other nanoparticles and facilitate their internalisation into targeted cells. [28,29] Despite the advantages of using PEG in pharmaceutical and biological applications (for more details see references [18,25,[30][31][32][33] ), its potential drawbacks are the occurrence of adverse side effects caused by the polymer itself or by its derivatives. PEG has already shown a tendency to induce clotting and clumping of cells, which may lead to embolism.…”

Section: Introductionmentioning

confidence: 99%

“…[18,25,33,35,36] There are other approaches available for chemical modification of the drug molecule, and indeed other approaches, which explore ways to facilitate association between Taxol and AuNPs, would be very valuable. The work reported here uses a two-step functionalisation of carboxylic acid-terminated thiols of AuNPs as delivery vehicles; this functionalisation strategy to connect Taxol to the nanoparticles has not been reported previously.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Modification Protocols on the Effectiveness of Gold Nanoparticles as Drug Delivery Vehicles for Killing of Breast Cancer Cells

et al. 2016

View full text Add to dashboard Cite

The current study evaluated the potential of gold nanoparticles (AuNPs) for the delivery of Taxol to breast cancer cells (T47D) using an in vitro cell culture model. For this study, new loading approaches and novel chemical attachments were investigated. Five different gold nanoparticle-based complexes were used to determine their cytotoxicity towards T47D cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) viability assay. There was no significant decrease (P . 0.05) in cell viability when T47D cells were treated with AuNPs that did not contain Taxol. However, cells were significantly killed by gold nanoparticles chemically conjugated to Taxol using three different approaches and one novel hybrid AuNP-Taxol nanoparticle, wherein no chemical bonds were involved. These Taxolloaded AuNPs were more effective at inducing cell death in vitro than a solution of free Taxol used to treat cells. This result demonstrated that Taxol could be released from the particles in the cell culture media for subsequent therapeutic action. Additionally, the experiments proved that the Taxol-loaded AuNPs were more toxic in a dose dependent manner than Taxol as a formulation for the treatment of breast cancer cells. The results of this study suggest that gold nanoparticles have potential for the efficient delivery of Taxol to breast cancer cells. This could provide a future solution as an alternative application method to overcome adverse side effects resulting from current high-dose treatment regimes.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Modification Protocols on the Effectiveness of Gold Nanoparticles as Drug Delivery Vehicles for Killing of Breast Cancer Cells

et al. 2016

View full text Add to dashboard Cite

show abstract

“…FT-IR microspectroscopy has allowed us to investigate the biochemical changes occurring in GNPs after interaction processes while TEM microscopy has enabled to observe the relative morphological modifications. The complete characterization of these processes is of fundamental importance for further manipulations required for GNPs theranostic applications [5].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Au Nanoparticles for Teranostic Applications

Delfino¹,

Lepore

Tatè

et al. 2014

Proceedings of International Electronic Conference on Sensors and Applications

View full text Add to dashboard Cite

Gold nanoparticles (GNPs) are very attractive materials due to their unique properties of small size, large surface area to volume ratio, high reactivity to the living cells, stability over high temperatures. These properties along with the evidence that GNPs are amenable to the attachment of biomolecules or ligands have led to the realization of several nanoparticle-based bio-devices for many theranostic applications and still boost a huge research effort in the field. In the present work absorption spectroscopy, static and dynamic light scattering, Fourier-Transform infrared (FT-IR) microspectroscopy and TEM microscopy were used to characterize different sized bare and biotinylated GNPs (20-70 nm diameter range). The aggregation process of the biotinylated particles induced by addition of neutravidin in the nanomolar range was investigated as a proof of concept of the approach. In particular, optical visible techniques were used for estimating the size of particles before and after the biotin capping procedure, FT-IR microspectroscopy and TEM microscopy to investigate the biochemical morphological changes occurring in GNPs after interaction processes.

show abstract

Gold Nanomaterials Bioconjugates

Yang

2014

Chemistry of Bioconjugates

View full text Add to dashboard Cite

Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy

Cited by 322 publications

References 29 publications

Effect of Modification Protocols on the Effectiveness of Gold Nanoparticles as Drug Delivery Vehicles for Killing of Breast Cancer Cells

Effect of Modification Protocols on the Effectiveness of Gold Nanoparticles as Drug Delivery Vehicles for Killing of Breast Cancer Cells

Preparation and Characterization of Au Nanoparticles for Teranostic Applications

Gold Nanomaterials Bioconjugates

Contact Info

Product

Resources

About