Gold Nanoparticles Sliding on Recyclable Nanohoodoos—Engineered for Surface‐Enhanced Raman Spectroscopy

Wu, Kaiyu; Li, Tao; Schmidt, Michael; Rindzevicius, Tomas; Boisen, Anja; Ndoni, Sokol

doi:10.1002/adfm.201704818

Cited by 63 publications

(54 citation statements)

References 46 publications

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“…One type of newly designed nanostructures is leaning nanopillar arrays that cluster together to form narrow interparticle gaps (1-10 nm) on the top of nanopillars. [65] Although these close-packed nanoparticles or nanopillars (usually at sub 10 nm) dramatically enhance SERS signaling, they are often subjected to poor reproducibility due to uncontrollable aggregation. [64c] A similar nanostructure type has also been synthesized by gold nanoparticles sliding on nanohoodoos and forming clusters via deposition and evaporation of deionized water (Figure 7c-e).…”

Section: Ordered Nanostructuresmentioning

confidence: 99%

Engineering State‐of‐the‐Art Plasmonic Nanomaterials for SERS‐Based Clinical Liquid Biopsy Applications

et al. 2019

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Precision oncology, defined as the use of the molecular understanding of cancer to implement personalized patient treatment, is currently at the heart of revolutionizing oncology practice. Due to the need for repeated molecular tumor analyses in facilitating precision oncology, liquid biopsies, which involve the detection of noninvasive cancer biomarkers in circulation, may be a critical key. Yet, existing liquid biopsy analysis technologies are still undergoing an evolution to address the challenges of analyzing trace quantities of circulating tumor biomarkers reliably and cost effectively. Consequently, the recent emergence of cutting-edge plasmonic nanomaterials represents a paradigm shift in harnessing the unique merits of surface-enhanced Raman scattering (SERS) biosensing platforms for clinical liquid biopsy applications. Herein, an expansive review on the design/synthesis of a new generation of diverse plasmonic nanomaterials, and an updated evaluation of their demonstrated SERS-based uses in liquid biopsies, such as circulating tumor cells, tumor-derived extracellular vesicles, as well as circulating cancer proteins, and tumor nucleic acids is presented. Existing challenges impeding the clinical translation of plasmonic nanomaterials for SERS-based liquid biopsy applications are also identified, and outlooks and insights into advancing this rapidly growing field for practical patient use are provided.

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Section: Ordered Nanostructuresmentioning

confidence: 99%

Engineering State‐of‐the‐Art Plasmonic Nanomaterials for SERS‐Based Clinical Liquid Biopsy Applications

et al. 2019

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“…The LSPR excitations that generate the EM “hot spots” in the AuNP structures depend on the polarization of the incident field. [ 32 ] Since AuNP clusters display random orientations, [ 8 ] which is often the case for SERS substrates, [ 33 ] illuminating a SERS substrate by a depolarized laser beam leads to more efficient excitation of the EM “hot spots,” that is, achieving higher surface‐averaged EM field enhancement factors (EFs), leading to stronger SERS signals since I SERS ∝ | E | 4 . [ 32 ] The influence of a depolarized laser excitation on different nanoparticle clusters was investigated using COMSOL software package (see Figure a,b).…”

Section: Resultsmentioning

confidence: 99%

Wide Line Surface‐Enhanced Raman Scattering Mapping

Ilchenko

Slipets

Rindzevicius

et al. 2020

Adv Materials Technologies

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Surface‐enhanced Raman spectroscopy (SERS)‐based molecular detection at extremely low concentrations often relies on mapping of a SERS substrate. This yields a large number (>1000) of SERS spectra that can improve the limit of detection; however, the signal collection time is a major constraint. In this work, a wide line (WL) laser focusing technique aimed at fast mapping of SERS substrates is presented. The WL technique enables acquisition of thousands of SERS spectra in a few seconds without missing any of the electromagnetic “hot spots” in the illuminated area. In addition, the SERS signal averaging across the line in the WL mode displays extremely high signal‐to‐noise ratios. The advantages of the WL technique for SERS‐based sensing are verified using different analyte molecules, that is, p‐coumaric acid and melamine. Results show that the limit of detection can be improved by one order of magnitude compared to results obtained using a commercial Raman microscope.

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“…Modern SERS substrates i) are compatible with large‐scale manufacturing processes, ii) have acceptable batch‐to‐batch SERS signal intensity variations, and iii) exhibit high and reproducible EFs over large surface areas . In addition, the most competitive SERS substrates offer new, important functionalities, e.g., reusability, transparency and softness, concentration of analytes in electromagnetic (EM) hotspots, or enhancement of the Raman signal using nanogap‐free structures, which further facilitates the development of SERS applications at low‐cost.…”

Section: Introductionmentioning

confidence: 99%

Wafer‐Scale Polymer‐Based Transparent Nanocorals with Excellent Nanoplasmonic Photothermal Stability for High‐Power and Superfast SERS Imaging

Nguyen

Rindzevicius

et al. 2019

Advanced Optical Materials

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Polymer‐based surface‐enhanced Raman spectroscopy (SERS) substrates offer distinctive advantages such as low‐cost and high optical transparency which allows direct detection of trace chemicals on target surfaces and easy microfluidic integration. However, incident‐laser‐induced localized surface plasmon resonances can generate heat that deform the polymer and significantly reduce the intensities of recorded SERS signals. Herein, a novel wafer‐scale polymer‐based transparent nanocoral (WTNC) SERS substrate with 3D electromagnetic “hotspots” is presented. Its fabrication is simple and lithography‐free. The novel SERS substrate demonstrates excellent nanoplasmonic heat resistance, high SERS sensitivity, and unmatched SERS signal uniformity with a relative standard deviation of ≈6% across 80 mm. Excellent photothermal stability is achieved by highly crosslinking SU‐8, a negative epoxy photoresist, raising its initial degradation temperature to ≈230 °C, much higher than the glass transition temperature of state‐of‐the‐art thermalplasts used in SERS substrates, including polyethylene terephthalate and poly(methyl methacrylate). The WTNC substrate can withstand very high laser irradiance of up to 300 kW cm−2, enabling superfast SERS imaging of analytes in extremely small quantities. A high resolution SERS image containing 10 201 spectra of ≈44 amol trans‐1,2‐bis(4‐pyridyl)ethylene is obtainable in <5 min. The WTNC substrate pushes the state‐of‐the‐art in polymer‐based SERS substrates and has great potential for rapid routine analyses.

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Gold Nanoparticles Sliding on Recyclable Nanohoodoos—Engineered for Surface‐Enhanced Raman Spectroscopy

Cited by 63 publications

References 46 publications

Engineering State‐of‐the‐Art Plasmonic Nanomaterials for SERS‐Based Clinical Liquid Biopsy Applications

Engineering State‐of‐the‐Art Plasmonic Nanomaterials for SERS‐Based Clinical Liquid Biopsy Applications

Wide Line Surface‐Enhanced Raman Scattering Mapping

Wafer‐Scale Polymer‐Based Transparent Nanocorals with Excellent Nanoplasmonic Photothermal Stability for High‐Power and Superfast SERS Imaging

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