Gold nanoparticles modified hollow carbon system for dual-responsive release and chemo-photothermal synergistic therapy of tumor

Zhao, Qinfu; Yang, Yang; Wang, Huili; Lei, Wei; Liu, Yixuan; Wang, Siling

doi:10.1016/j.jcis.2019.07.005

Cited by 49 publications

(19 citation statements)

References 33 publications

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“…The lethality rate of d -Au NPs and l -Au NPs toward E. coli were increased to 96.8% and 65.4%, respectively, while the lethality rate of d -cys, l -cys or Au NPs was only 46%, 27% and 20%, respectively. The significant antibacterial activity of d -/ l -Au NPs was attributed to two aspects: first, the stability of cysteine is greatly increased after immobilization via Au-S bonding on the surface of Au NPs, which has a significant association with antimicrobial properties [ 49 ]. Besides, Au NPs may concentrate antibacterial cysteine on their surfaces to result in polyvalent effects; thus, d -/ l -Au NPs can specifically attack biological targets in bacteria [ 50 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

Plasmon-Enhanced Antibacterial Activity of Chiral Gold Nanoparticles and In Vivo Therapeutic Effect

Wang

Zhang

et al. 2021

Nanomaterials

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d-cysteine (d-cys) has been demonstrated to possess an extraordinary antibacterial activity because of its unique steric configuration. However, inefficient antibacterial properties seriously hinder its wide applications. Here, cysteine-functionalized gold nanoparticles (d-/l-Au NPs) were prepared by loading d-/l-cysteine on the surface of gold nanoparticles for the effective inhibition of Escherichia coli (E. coli) in vitro and in vivo, and the effects on the intestinal microflora in mice were explored during the treatment of E. coli infection in the gut. We found that the antibacterial activity of d-/l-Au NPs was more than 2–3 times higher than pure d-cysteine, l-cysteine and Au NPs. Compared with l-Au NPs, d-Au NPs showed the stronger antibacterial activity, which was related to its unique steric configuration. Chiral Au NPs showed stronger destructive effects on cell membrane compared to other groups, which further leads to the leakage of the cytoplasm and bacterial cell death. The in vivo antibacterial experiment illustrated that d-Au NPs displayed impressive antibacterial activity in the treatment of E. coli-infected mice comparable to kanamycin, whereas they could not affect the balance of intestinal microflora. This work is of great significance in the development of an effective chiral antibacterial agent.

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Section: Resultsmentioning

confidence: 99%

Plasmon-Enhanced Antibacterial Activity of Chiral Gold Nanoparticles and In Vivo Therapeutic Effect

Wang

Zhang

et al. 2021

Nanomaterials

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“…Moreover, intracellularly, PAAs segments could be degraded easily by GSH, which was overexpressed in HNE-1 cells (Huang et al., 2019). GSH mediated detoxification has been reported as one of the most important mechanisms responsible for the cancer drug resistance (Zhao et al., 2019). As an antioxidant in vivo , GSH prevents the damage of cellular components caused by chemical substances including heavy metals and drug metabolites, etc (Li et al., 2019).…”

Section: Resultsmentioning

confidence: 99%

A cationic polymeric prodrug with chemotherapeutic self-sensibilization co-delivering MMP-9 shRNA plasmid for a combined therapy to nasopharyngeal carcinoma

Liu

Wu²,

Chen

et al. 2019

Drug Delivery

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To obtain a high-efficiency drug and gene co-delivery system to HNE-1 tumor therapy, a polymeric prodrug (PAAs-MTX) with chemotherapeutic sensibilization was synthesized consisting of a GSHresponse hyperbranched poly(amido amine) (PAAs) and an antitumor drug of methotrexate (MTX). Then, the targeting molecule to HNE-1 cells, transferrin (Tf), was conjugated to form the Tf-PAAs-MTX. This polymeric prodrug could deliver MMP-9 shRNA plasmid (pMMP-9) again to form the drug and gene co-delivery system of Tf-PAAs-MTX/pMMP-9. The co-delivery system showed the effective drug and gene delivery ability with high cytotoxicity and gene transfection efficiency to HNE-1 cells. Besides that, Tf-PAAs-MTX also showed the chemotherapeutic sensibilization effect, the formulation containing PAAs segments showed much higher cytotoxicity than that of free MTX. Benefiting from the sensibilization effect and MTX/pMMP-9 co-delivery strategy, this Tf-PAAs-MTX/pMMP-9 co-delivery system exhibited the significantly improved therapeutic efficacy to HNE-1 tumor in a combined manner which was confirmed by in vitro and in vivo assays. Moreover, its biocompatibility, especially the blood compatibility was analyzed. This polymeric prodrug provided an easily delivery system combining the drug/gene co-delivery, chemotherapeutic sensibilization and targeting into one single platform, which showed a promising application in nasopharyngeal carcinoma therapy.

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“…The multifunctional therapeutic system with targeted drug delivery, imaging, and a combination therapy mode, which can greatly increase therapeutic efficacy and minimize the damage to normal tissues, has been extensively studied. [1][2][3] The integration of the thermo-chemo therapeutic system consisting of gold nanocomposites, 4 carbon nanotubes, 5 and magnetic mesoporous microspheres 6 is an effective therapeutic system in vitro and vivo. Despite achievements that have been made, the integrated therapeutic systems usually loading an exogenous drug (doxorubicin, paclitaxel, and macromolecular protein), which commonly bring undesirable side effects, ineffective delivery to the tumor sites, and tumor cell resistance, [7][8][9] are still facing difficult problems.…”

Section: Introductionmentioning

confidence: 99%

Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy

Zhang

Zhou

et al. 2021

IJN

Self Cite

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Introduction:Aim to obtain a NO donor that can control released NO in vivo with the high efficacy of tumor suppression and targeting, a nanoplatform consisting of FA-Fe 3 O 4 @mSiO 2 -Au/DOX was constructed. Methods: In vitro, the nanoplatform catalyzed NO's release with the maximum value of 4.91 μM within 60 min at 43°C pH=5.0, which was increased by 1.14 times when the temperature was 37°C. In vivo, 11.7 μg Au in the tumor tissue was found to catalyze S-nitrosoglutathione continuously, and 54 μM NO was checked out in the urine. Results and Discussion: The high concentration of NO was found to increase the apoptotic rate and to reduce tumor proliferation. In the chemo-photothermal combination therapy, the tumor inhibition rate was increased up to 94.3%, and Au's contribution from catalyzing NO release NO was 8.17%.

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Gold nanoparticles modified hollow carbon system for dual-responsive release and chemo-photothermal synergistic therapy of tumor

Cited by 49 publications

References 33 publications

Plasmon-Enhanced Antibacterial Activity of Chiral Gold Nanoparticles and In Vivo Therapeutic Effect

Plasmon-Enhanced Antibacterial Activity of Chiral Gold Nanoparticles and In Vivo Therapeutic Effect

A cationic polymeric prodrug with chemotherapeutic self-sensibilization co-delivering MMP-9 shRNA plasmid for a combined therapy to nasopharyngeal carcinoma

Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy

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