Gold Nanoparticles for Tracking Bacteria Clearance by Regulated Irrigation and Negative Pressure-Assisted Wound Therapy

Motiei, Menachem; Sadan, Tamar; Zilony, Neta; Topaz, Guy; Popovtzer, Rachela; Topaz, Moris

doi:10.2217/nnm-2018-0053

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…Treatments started 5 min after the removal of the NaOH‐saturated filter paper square. The rats underwent water irrigation or iNPWT 14 at an equivalent flow rate of 30 mL/min for 30 min. Thereafter, the wound conditions were monitored, and the rats were sacrificed on day 3 post‐wounding for histological analysis.…”

Section: Methodsmentioning

confidence: 99%

The early association of water irrigation with negative pressure wound therapy does not more efficiently reduce the depth of the alkali infiltration progress into the burn

Wang

et al. 2022

International Wound Journal

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Water irrigation is an efficacious decontaminating method for dermis exposures to corrosive agents and hence has been widely applied to treat especially alkali burns. Nevertheless, once alkali has infiltrated the deep subcutaneous tissue, washing the tissue surface with water irrigation does not attenuate the damage progress. Therefore, significant efforts have been devoted to promising strategies aimed at removing the deeply infiltrated lye. According to a recent report, the negative pressure wound therapy (NPWT) reduces the pH value of the exudate from alkali-provoked burns thus accelerating wound healing. However, it remains to be ascertained whether or not NPWT coupled with water irrigation, that is, iNPWT, more effectively hinders the alkali injury deepening. In this study, we compared the effectiveness of an early application of water irrigation with or without NPWT in preventing the progressive deepening of the alkali burn in an animal model. Our histological examination results showed no appreciable difference in tissue injury depth, dermal retention, inflammatory cell infiltration, re-epithelization, and cellular function between iNPWT and water irrigation alone treatments. Thus, our results prove that the more expensive NPWT coupled with water irrigation does not more effectively hinder the alkali's injury deepening.Hence, iNPWT use should be more cautious in clinical practice.alkali burn, NPWT, water irrigation, wound healing Key Messages• the present investigation is for the first time to explore the effectiveness of iNPWT in preventing the progressive deepening of the alkali burn in an animal model

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Section: Methodsmentioning

confidence: 99%

The early association of water irrigation with negative pressure wound therapy does not more efficiently reduce the depth of the alkali infiltration progress into the burn

Wang

et al. 2022

International Wound Journal

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“…Supplemental oxygen reverses the reduced oxygen partial pressure in the wound and may inhibit anaerobic bacterial growth [ 9 , 10 ]. Concurrent hydrodynamic irrigation accelerates the evacuation of infectious material from the wound [ 11 ]. Irrigation also may provide a means for regulated antibiotic administration directly into the wound.…”

Section: Introductionmentioning

confidence: 99%

Minimizing treatment complexity of combat-related soft tissue injuries using a dedicated tension relief system and negative pressure therapy augmented by high-dose in situ antibiotic therapy and oxygen delivery: a retrospective study

et al. 2021

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Background Following combat-related, extensive soft tissue injury from gunshot wounds or blasts, prolonged duration from injury to full wound closure is associated with infection, increased morbidity and mortality, failure to mobilize, poor functional outcome and increased cost. The purpose of this study was to evaluate a novel treatment enabling early primary closure of combat wounds. Methods This was a retrospective study of 10 soldiers and civilians with extensive combat-related soft tissue limb injuries (5 gunshot wounds, 5 blasts) treated using the TopClosure® Tension Relief System (TRS) with simultaneous administration of regulated oxygen-enriched and irrigation negative pressure-assisted wound therapy (ROINPT) via the Vcare α® device. Results Nine patients were treated during the acute phase of injury and one was treated following removal of a flap due to deep infection 20 years after injury and flap reconstruction. Two patients had upper limb injury and the rest lower limb injury. With the aid of the TRS and/or ROINPT, immediate primary closure during reconstruction was achieved in 6 patients and delayed primary closure in three. Only one patient required a skin graft to close a small area of the wound after most of the wound had been closed by delayed primary closure. Wound closure was achieved within 0–37 days (median: 12.5 days, interquartile range: 2.75–19.75) from injury. Conclusions The TRS is a novel device for effective, early skin stretching and secure wound closure through the application of stress relaxation and mechanical creep, achieving primary closure of large defects using a simplified surgical technique and reducing the need for closure using skin grafts and flaps and the use of tissue expanders. Delivering supplemental oxygen to the wound by ROINPT reverses the reduced oxygen levels inherent in conventional negative pressure-assisted wound therapy, mitigating anaerobic contamination and reducing infection. Irrigation may accelerate the evacuation of infectious material from the wound and provide a novel method for antibiotic administration. The combination of TRS and ROINPT devices allow for early primary closure with improved functionality of combat-related limb injuries.

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“…This feature is augmented by the use of a semi-transparent (off-white) sponge that permits easy visualization of bleeding (and infection). Supplemental oxygen reverses the reduced partial pressure of oxygen in the wound induced by conventional vacuum systems, and may inhibit anaerobic bacterial growth (4,5). Concurrent antibiotic irrigation of the wound hydrodynamically accelerates the evacuation of infectious material from the wound (6) and may effectively decontaminate the wound (7).…”

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confidence: 99%

Case Report: Delayed Primary Wound Closure After Extensive Abdominal Wall Resection for Infection and Malignancy Using TopClosure®

et al. 2021

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The closure of a massive abdominal wall defect is illustrated using a novel dynamic closure technique - the TopClosure® tension relief system. This system attaches to the abdominal wall immediately after laparotomy and allows for early approximation of the skin, avoiding an open abdomen and the complications associated with this. The technique in this case was employed after extensive resection of the abdominal wall for infected skin metastases of colonic adenocarcinoma and circumvented post-operative ventilation and open abdomen. Early recovery after such extensive surgery is important in terms of patient morbidity and mortality. In this case, primary surgery may not have been an acceptable risk to undertake without the option of Top Closure of the abdomen. We illustrate the technique of abdominal wall closure through a series of images of the procedure.

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Gold Nanoparticles for Tracking Bacteria Clearance by Regulated Irrigation and Negative Pressure-Assisted Wound Therapy

Abstract: This nanotechnology-based approach demonstrates that RI-NPT is essential for reducing bacterial load and, thus, for promoting wound healing.

Cited by 4 publications

References 37 publications

The early association of water irrigation with negative pressure wound therapy does not more efficiently reduce the depth of the alkali infiltration progress into the burn

The early association of water irrigation with negative pressure wound therapy does not more efficiently reduce the depth of the alkali infiltration progress into the burn

Minimizing treatment complexity of combat-related soft tissue injuries using a dedicated tension relief system and negative pressure therapy augmented by high-dose in situ antibiotic therapy and oxygen delivery: a retrospective study

Case Report: Delayed Primary Wound Closure After Extensive Abdominal Wall Resection for Infection and Malignancy Using TopClosure®

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