Gold Nanoparticles for Multimodal High-Resolution Imaging of Transplanted Cells for Retinal Replacement Therapy

Chemla, Yoav; Betzer, Oshra; Markus, Amos; Motiei, Menachem; Popovtzer, Rachela; Mandel, Yossi

doi:10.2217/nnm-2018-0299

Cited by 44 publications

(30 citation statements)

References 49 publications

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“…Betzer et al (2015) developed a protocol for labeling different types of cells with AuNP for in vivo applications (Figure 8a,b). This technology was applied in various mouse disease models for noninvasive CT monitoring of mesenchymal stem cell (MSC) in brain disorder treatment (Betzer et al, 2014; Shwartz et al, 2017), photoreceptor precursors in retinal replacement therapy (Chemla et al, 2019), and melanoma‐specific T cells in cancer immunotherapy treatment (Figure 8c–f) (Meir et al, 2015). Design principles for cell tracking were further established using CT imaging after intramuscular stem cell transplantation in a mouse model of Duchenne muscular dystrophy.…”

Section: X‐ray Contrast Agentsmentioning

confidence: 99%

Nanoparticle contrast agents for X‐ray imaging applications

Hsu

Nieves

Betzer

et al. 2020

WIREs Nanomed Nanobiotechnol

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X-ray imaging is the most widely used diagnostic imaging method in modern medicine and several advanced forms of this technology have recently emerged. Iodinated molecules and barium sulfate suspensions are clinically approved X-ray contrast agents and are widely used. However, these existing contrast agents provide limited information, are suboptimal for new X-ray imaging techniques and are developing safety concerns. Thus, over the past 15 years, there has been a rapid growth in the development of nanoparticles as X-ray contrast agents. Nanoparticles have several desirable features such as high contrast payloads, the potential for long circulation times, and tunable physicochemical properties. Nanoparticles have also been used in a range of biomedical applications such as disease treatment, targeted imaging, and cell tracking. In this review, we discuss the principles behind X-ray contrast generation and introduce new types of X-ray imaging modalities, as well as potential elements and chemical compositions that are suitable for novel contrast agent development. We focus on the progress in nanoparticle X-ray contrast agents developed to be renally clearable, long circulating, theranostic, targeted, or for cell tracking. We feature agents that are used in conjunction with the newly developed multi-energy computed tomography and mammographic imaging technologies. Finally, we offer perspectives on current limitations and emerging research topics as well as expectations for the future development of the field.

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Section: X‐ray Contrast Agentsmentioning

confidence: 99%

Nanoparticle contrast agents for X‐ray imaging applications

Hsu

Nieves

Betzer

et al. 2020

WIREs Nanomed Nanobiotechnol

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“…The application of nanomaterials is emerging in ocular research especially in the treatment and therapies of DR. Nanoparticles such as silver, gold, titanium dioxide have their intrinsic therapeutic properties and potentials [155]. Early literature also shows that these metal based nanoparticles are being used in the treatment of DR [156][157][158].…”

Section: Nanomedicinementioning

confidence: 99%

Non-invasive multimodal imaging of Diabetic Retinopathy: A survey on treatment methods and Nanotheranostics

Sadasivam¹,

Gopinath²,

Shakya³

et al. 2021

Nanotheranostics

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Diabetes Retinopathy (DR) is one of the most prominent microvascular complications of diabetes. It is one of the pre-eminent causes for vision impairment followed by blindness among the working-age population worldwide. The de facto cause for DR remains challenging, despite several efforts made to unveil the mechanism underlying the pathology of DR. There is quite less availability of the low cost pre-emptive theranostic imaging tools in terms of in-depth resolution, due to the multiple factors involved in the etiology of DR. This review work comprehensively explores the various reports and research works on all perspectives of diabetic retinopathy (DR), and its mechanism. It also discusses various advanced non-destructive imaging modalities, current, and future treatment approaches. Further, the application of various nanoparticle-based drug delivery strategies used for the treatment of DR are also discussed. In a nutshell, the present review work bolsters the pursuit of the development of an advanced non-invasive optical imaging modal with a nano-theranostic approach for the future diagnosis and treatment of DR and its associated ocular complications.

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“…[ 34 ] Gold nanomaterials provide distinctive reflective signals beyond the native tissues, and their highly tunable SPR effects can further improve the intensity of backscattered light and thereafter result in strong OCT signals. [ 35–37 ]…”

Section: Gold Nanomaterials For Optical Detection and Single‐mode Imagingmentioning

confidence: 99%

The Golden Age: Shining the Light on Theragnostics

Yang

Wang

2021

Advanced NanoBiomed Research

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Gold nanoparticles have attracted unprecedented attention as one of the leading nanomaterials in the field of biomedicine. Of particular interest are their inherent and geometrically tunable optical properties upon the interaction with light, facilitating breakthroughs in light‐mediated diagnosis and therapeutics. Herein, an up‐to‐date overview of the current research in utilizing versatile gold‐based nanosystems with distinctive optical features for optical imaging and phototherapy is provided. The recent advances in optical biosensing, surface‐enhanced Raman scattering‐based detection, photoacoustic imaging, optical coherence tomography, photothermal therapy, light‐triggered drug release, photodynamic therapy, and optomodulation of neural functions using the novel and elegant gold nanostructures of unique design are summarized. In recognition of the burgeoning popularity of integrating multiple diagnostic and therapeutic functions in one system, recent developments of various multifunctional gold nanoplatforms for the light‐enabled concomitant diagnosis and therapy are also highlighted. In the end, the current limitations and perspectives in clinical translation of gold nanomaterial‐assisted photodiagnosis and phototherapy are discussed along with the concluding remarks.

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Gold Nanoparticles for Multimodal High-Resolution Imaging of Transplanted Cells for Retinal Replacement Therapy

Cited by 44 publications

References 49 publications

Nanoparticle contrast agents for X‐ray imaging applications

Nanoparticle contrast agents for X‐ray imaging applications

Non-invasive multimodal imaging of Diabetic Retinopathy: A survey on treatment methods and Nanotheranostics

The Golden Age: Shining the Light on Theragnostics

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