Gold nanoparticles for designing of smart colorimetric logic gates operations and scavengers for mercury ions in water

Kumar, Anshu; Paul, Parimal

doi:10.1039/c4ay00914b

Cited by 11 publications

(8 citation statements)

References 49 publications

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“…27,28 Interaction of these nanoparticles with analytes causes aggregation and/or change in size, shape, interparticle networking pattern, etc., resulting in changes in SPR absorption band and color of the solution, which is easily detectable by the naked eye even at low concentration. 29−31 Because of this unique property and also due to their simple and rapid action with high selectivity and sensitivity, the use of nanoparticles as colorimetric sensing material has become an emerging area of research. Among metal-based nanoparticles, both gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) are of particular interest because of their high sensitivity and distinct color change, which can be noted even if a minor change occurs in the nanoparticles’ environment.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Calixarene-Capped Silver Nanoparticles for Colorimetric and Amperometric Detection of Mercury (Hg^II, Hg⁰)

2019

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Calixarene-functionalized water dispersible silver nanoparticles have been synthesized and characterized on the basis of UV–vis, IR, X-ray diffraction, and high-resolution transmission electron microscopy analysis, and their sensing properties toward metal ions have been investigated. They selectively detect Hg 2+ and Hg 0 in solution and vapor phases, respectively, with distinct color change. Interference study with mixture of metal ions revealed no interference from any other metal ions used in this study. Their mechanism of detection involved Hg 2+ -aided displacement of calixarene moiety from the surface of the functionalized nanoparticles, followed by the formation of Ag–Hg amalgam due to interaction of Hg 2+ with Ag 0 and also the formation of assembly of Ag 0 nanoparticles by dipole–dipole interaction of the bare-surfaced nanoparticles. Electrochemical study revealed that with the aid of functionalized nanoparticles, Hg 2+ can be detected amperometrically with high sensitivity. The detection limits obtained for Hg 2+ by UV–vis study and amperometry are 0.5 nM (0.1 ppb) and 10 nM (2 ppb), respectively. The new material has been used to detect Hg 2+ in aqueous real sample and Hg 0 in soil sample.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Calixarene-Capped Silver Nanoparticles for Colorimetric and Amperometric Detection of Mercury (Hg^II, Hg⁰)

2019

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“…Figure 4b shows 96-well UV plates in which the antigen had been gradually and equally added to mAb and pAb solutions. For the pAb experiment, the resulting colour change was observable by the naked eye whereas no colour change was observed for the other Ab [34][35][36][37].…”

Section: The Pab-based Immunonanosensormentioning

confidence: 78%

“…As depicted in Figure 5b, the ligand caused the AuNPs to aggregate, which led to interaction between their individual SPR bands and consequently, to plasmonic coupling. As a result, unlike the reddish mFcL/AuNPs, the mFcL/AuNPs containing the bipodal ligand were purple, exhibiting a 10-nm redshift in their UV-Vis spectrum relative to that of the former (Figure 5c) [34][35][36][37]. Moreover, when 1 mL of a conc.…”

Section: Provoking Nanoparticle Aggregation To Induce An Increase In mentioning

confidence: 87%

Control of Electron‐transfer in Immunonanosensors by Using Polyclonal and Monoclonal Antibodies

et al. 2016

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The design and operation of biosensors is not trivial. For instance, variation in the output signal during monitoring of analytes can not usually be controlled. Hence, if such control were possible, and could be triggered on demand, it would greatly facilitate system design and operation. Herein, we report the design of two types of voltamperometric immunosensors, in which the magnitude of the current output signal (differential pulse voltammetry [DPV]) can be increased or decreased as needed. The designed systems use monoclonal and polyclonal anti‐human IgG antibodies, conjugated to monopodal ferrocene‐modified gold nanoparticles that are casted onto screen‐printed carbon electrodes (Ab/mFcL/AuNPs/SPCEs). Upon addition of human IgG as antigen, the systems exhibit opposite responses according to the Ab: the current decreases when monoclonal Ab is used, whereas it increases when polyclonal Ab is used. We attributed the former response to inhibition of electron‐transfer (due to the formation of a protein layer), and the latter response, to a global increase in electron transfer (induced by the aggregation of gold nanoparticles). These effects were confirmed by studying a custom‐made lipoic acid‐based bipodal ligand, which confirmed that the increase in current is effectively induced by the aggregation of the modified nanoparticles (pAb/mFcL/AuNPs). Both sensors have large dynamic ranges, although the pAb‐based one was found to be 3.3‐times more sensitive. Tests of selectivity and specificity for ovalbumin, α‐lactalbumin and serum bovine albumin showed that the immunosensors are highly selective and specific, even in the presence of up to 1000‐fold levels of potentially competitive proteins. The limit of detection for human IgG using the pAb/mFcL/AuNP bioconjugate was estimated to be 0.85 ng/mL. The pAb/mFcL/AuNPs‐based biosensor has used to determine amounts of human IgG in real sample.

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“…The coralyne-mediated aggregation of AuNPs could be reversed by adding negatively charged targets having high affinity to coralyne, and this system behavior corresponded to an INHIBIT logic gate. Paul and Kumar demonstrated sensing Hg 2+ ions using dopamine/H 2 PO 4 – -mediated cross-linking of AuNPs as an indicator . Dopamine molecules, due to the presence of catechol groups able to displace citrate ions, could be readily adsorbed onto AuNPs.…”

Section: Logic-gated Nanoagents For Specific Biomedical Applicationsmentioning

confidence: 99%

“…Paul and Kumar demonstrated sensing Hg 2+ ions using dopamine/H 2 PO 4 − -mediated cross-linking of AuNPs as an indicator. 158 surface of AuNRs. 159 The positively charged AuNRs were prepared using a seed-mediated approach.…”

Section: Chemical Reviewsmentioning

confidence: 99%

Advanced Smart Nanomaterials with Integrated Logic-Gating and Biocomputing: Dawn of Theranostic Nanorobots

2018

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Accurate and precise drug delivery is the key to successful therapy. Monoclonal antibodies, which can transport therapeutic payload to cells expressing specific markers, have paved the way for targeted drug delivery and currently show tremendous clinical success. However, in those abundant cases, when a disease cannot be characterized by a single specific marker, more sophisticated drug delivery systems are required. To enhance targeting accuracy, diverse smart materials have been proposed that can also react to stimuli like variations of pH, temperature, magnetic field, etc. Furthermore, over the past few years a new category of smart materials has emerged, which can not only respond to virtually any biochemical or physical stimulus but also simultaneously analyze several cues and, moreover, can be programmed to use Boolean logic for such analysis. These advanced biocomputing agents have the potential to become a basis for future nanorobotic devices that could overcome some of the grand challenges of modern biomedicine. Here, with a brief introduction to the multidisciplinary field of biomolecular computing, we will review the concepts of nanomaterials with built-in biocomputing capabilities, which can be potentially used for drug delivery and other theranostic applications.

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Gold nanoparticles for designing of smart colorimetric logic gates operations and scavengers for mercury ions in water

Cited by 11 publications

References 49 publications

Synthesis of Calixarene-Capped Silver Nanoparticles for Colorimetric and Amperometric Detection of Mercury (Hg^II, Hg⁰)

Synthesis of Calixarene-Capped Silver Nanoparticles for Colorimetric and Amperometric Detection of Mercury (Hg^II, Hg⁰)

Control of Electron‐transfer in Immunonanosensors by Using Polyclonal and Monoclonal Antibodies

Advanced Smart Nanomaterials with Integrated Logic-Gating and Biocomputing: Dawn of Theranostic Nanorobots

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Gold nanoparticles for designing of smart colorimetric logic gates operations and scavengers for mercury ions in water

Cited by 11 publications

References 49 publications

Synthesis of Calixarene-Capped Silver Nanoparticles for Colorimetric and Amperometric Detection of Mercury (HgII, Hg0)

Synthesis of Calixarene-Capped Silver Nanoparticles for Colorimetric and Amperometric Detection of Mercury (HgII, Hg0)

Control of Electron‐transfer in Immunonanosensors by Using Polyclonal and Monoclonal Antibodies

Advanced Smart Nanomaterials with Integrated Logic-Gating and Biocomputing: Dawn of Theranostic Nanorobots

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Synthesis of Calixarene-Capped Silver Nanoparticles for Colorimetric and Amperometric Detection of Mercury (Hg^II, Hg⁰)

Synthesis of Calixarene-Capped Silver Nanoparticles for Colorimetric and Amperometric Detection of Mercury (Hg^II, Hg⁰)