Gold nanoparticles enable selective light-induced contents release from liposomes

Corticosteroids and Anti-Complement Therapy in Retinal Diseases

“…The results indicated that vectosomes were able to distribute in the various retinal layers and RPE (Normand et al 2005). Another approach for light-sensitive drug delivery is gold nanoparticle-loaded liposomes, wherein UV light-induced heating of gold nanorods melts and releases the contents of the liposomes (Paasonen et al 2007). In a recent study, a light-activated in situ gelling system has been designed for suprachoroidal application of bevacizumab, using polycaprolactone dimethacrylate and HEMA.…”

Supramolecular nanoscale assemblies for cancer diagnosis and therapy

“…Nativo et al showed controlled intracellular uptake of AuNPs by liposomes [200] Furthermore, Chithrani et al demonstrated a thousand-fold enhancement in cellular uptake of small (1.4 nm) Au NPs by liposomes [201]. Paasonen et al suggested a principle of controlled drug release from liposomes by photothermal effect of AuNPs exposed to ultraviolet (UV) irradiation [202]. Due to unique optical properties of surface plasmon resonance of AuNPs drug delivery by this nanosystem can be combined with non-invasive non-ionizing therapeutic approaches such as radiofrequency ablation (RFA), photothermal therapy (PTT) or photodynamic therapy (PDT).…”

Localized fields, global impact: Industrial applications of resonant plasmonic materials

“…44 Beyond cancer therapeutics, photothermal heating can be used for controlled, local dosing, as illustrated in Figure 3b . Plasmonic nanoparticles have been used to trigger the release of drugs from various materials, including liposomes 45 and hydrogels, 46 as well as to transport and release DNA for targeted gene therapy. 47 Combined diagnostics and therapeutics is made possible by using nanoparticles as contrast agents in imaging, including magnetic resonance imaging, 48 optical coherence tomography, 49 and photoacoustic tomographic imaging.…”