Gold Nanoparticles Crossing Blood-Brain Barrier Prevent HSV-1 Infection and Reduce Herpes Associated Amyloid-βsecretion

Ri, Iusupova; S, Mj; M, Fj; B, Mj; Mf, Ma

doi:10.3390/jcm9010155

Cited by 24 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three different gold nanoparticles, namely, NPAuG1-S2, NPAuG2-S4, and NPAuG3-S8, were evaluated for antiviral activity against HSV-1. The results suggested that these nanoparticles prevented viral entry and thus reduced HSV-1 infection [ 180 ]. In one study, nonfunctionalized AuNPs were used for the evaluation of antiviral efficacy.…”

Section: Therapeutic Strategies Available For Herpes Infectionsmentioning

confidence: 99%

An Insight into Current Treatment Strategies, Their Limitations, and Ongoing Developments in Vaccine Technologies against Herpes Simplex Infections

Sharma

Akojwar

et al. 2023

Vaccines

View full text Add to dashboard Cite

Herpes simplex virus (HSV) infection, the most prevalent viral infection that typically lasts for a lifetime, is associated with frequent outbreaks of oral and genital lesions. Oral herpes infection is mainly associated with HSV-1 through oral contact, while genital herpes originates due to HSV-2 and is categorized under sexually transmitted diseases. Immunocompromised patients and children are more prone to HSV infection. Over the years, various attempts have been made to find potential targets for the prevention of HSV infection. Despite the global distress caused by HSV infections, there are no licensed prophylactic and therapeutic vaccines available on the market against HSV. Nevertheless, there are numerous promising candidates in the pre-clinical and clinical stages of study. The present review gives an overview of two herpes viruses, their history, and life cycle, and different treatments adopted presently against HSV infections and their associated limitations. Majorly, the review covers the recent investigations being carried out globally regarding various vaccine strategies against oral and genital herpes virus infections, together with the recent and advanced nanotechnological approaches for vaccine development. Consequently, it gives an insight to researchers as well as people from the health sector about the challenges and upcoming solutions associated with treatment and vaccine development against HSV infections.

show abstract

Section: Therapeutic Strategies Available For Herpes Infectionsmentioning

confidence: 99%

An Insight into Current Treatment Strategies, Their Limitations, and Ongoing Developments in Vaccine Technologies against Herpes Simplex Infections

Sharma

Akojwar

et al. 2023

Vaccines

View full text Add to dashboard Cite

show abstract

“…HSV‐1 infection can potentially disrupt the integrity of the BBB, permitting the virus to infiltrate the brain and give rise to encephalitis. Moreover, HSV‐1 infection can disturb the equilibrium between the amyloidogenic and non‐amyloidogenic pathways, leading to an increased buildup of amyloid‐β peptides, recognised as hallmark features in various neurodegenerative diseases 95 …”

Section: Neuroinflammation and Its Role In Hsv Infectionmentioning

confidence: 99%

Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries

Hussain,

Gupta,

Samuel

et al. 2023

Reviews in Medical Virology

View full text Add to dashboard Cite

The immunopathology of herpes simplex virus (HSV)‐associated neuroinflammation is a captivating and intricate field of study within the scientific community. HSV, renowned for its latent infection capability, gives rise to a spectrum of neurological expressions, ranging from mild symptoms to severe encephalitis. The enigmatic interplay between the virus and the host's immune responses profoundly shapes the outcome of these infections. This review delves into the multifaceted immune reactions triggered by HSV within neural tissues, intricately encompassing the interplay between innate and adaptive immunity. Furthermore, this analysis delves into the delicate equilibrium between immune defence and the potential for immunopathology‐induced neural damage. It meticulously dissects the roles of diverse immune cells, cytokines, and chemokines, unravelling the intricacies of neuroinflammation modulation and its subsequent effects. By exploring HSV's immune manipulation and exploitation mechanisms, this review endeavours to unveil the enigmas surrounding the immunopathology of HSV‐associated neuroinflammation. This comprehensive understanding enhances our grasp of viral pathogenesis and holds promise for pioneering therapeutic strategies designed to mitigate the neurological ramifications of HSV infections.

show abstract

“…Further studies indicate that the treatment with Au and zinc oxide (ZnO) NPs can effectively improve oxidant/antioxidant status and neuronal impairment by regulating different genes altered following Schistosoma mansoni infection in mice ( Dkhil et al, 2015 ; Bauomy, 2020 ). Similarly, Au NPs have been shown to reduce herpes simplex virus-1 infection–associated neurological defects by attenuating Aβ peptides aggregation and β-secretase activities ( I et al, 2020 ). Otherwise, drug delivery with NPs has also shown enormous potential in treating cerebral tuberculosis, encephalitis virus infection, and amoebic meningoencephalitis infections in mouse models ( Marcianes et al, 2017 ; Rajendran et al, 2017 ; LaBauve et al, 2018 ).…”

Section: Nanotechnology In Brain Diseases and Disordersmentioning

confidence: 99%

The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders

Ngowi

Wang

Qian

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Brain is by far the most complex organ in the body. It is involved in the regulation of cognitive, behavioral, and emotional activities. The organ is also a target for many diseases and disorders ranging from injuries to cancers and neurodegenerative diseases. Brain diseases are the main causes of disability and one of the leading causes of deaths. Several drugs that have shown potential in improving brain structure and functioning in animal models face many challenges including the delivery, specificity, and toxicity. For many years, researchers have been facing challenge of developing drugs that can cross the physical (blood–brain barrier), electrical, and chemical barriers of the brain and target the desired region with few adverse events. In recent years, nanotechnology emerged as an important technique for modifying and manipulating different objects at the molecular level to obtain desired features. The technique has proven to be useful in diagnosis as well as treatments of brain diseases and disorders by facilitating the delivery of drugs and improving their efficacy. As the subject is still hot, and new research findings are emerging, it is clear that nanotechnology could upgrade health care systems by providing easy and highly efficient diagnostic and treatment methods. In this review, we will focus on the application of nanotechnology in the diagnosis and treatment of brain diseases and disorders by illuminating the potential of nanoparticles.

show abstract

Gold Nanoparticles Crossing Blood-Brain Barrier Prevent HSV-1 Infection and Reduce Herpes Associated Amyloid-βsecretion

Cited by 24 publications

References 45 publications

An Insight into Current Treatment Strategies, Their Limitations, and Ongoing Developments in Vaccine Technologies against Herpes Simplex Infections

An Insight into Current Treatment Strategies, Their Limitations, and Ongoing Developments in Vaccine Technologies against Herpes Simplex Infections

Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries

The Application of Nanotechnology for the Diagnosis and Treatment of Brain Diseases and Disorders

Contact Info

Product

Resources

About