Gold nanoparticles coated with gadolinium-DTPA-bisamide conjugate of penicillamine (Au@GdL) as a T1-weighted blood pool contrast agent

Kim, Hee Kyung; Jung, Hee-Young; Park, Ji Ae; Huh, Man-Il; Jung, Jin Hyang; Chang, Yongmin; Kim, Tae‐Jeong

doi:10.1039/c0jm00163e

Cited by 33 publications

(24 citation statements)

References 45 publications

(51 reference statements)

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“…(64) Nevertheless, the citrate capping ligands can be easily displaced with the desired coating material to make stable, biocompatible nanoparticles (Figure 2A). (46) Gold nanoparticles synthesized using variants of this method can be used to grow a variety of shapes such as nanorods or stars. (67,68)…”

Section: Nanocrystal Synthesismentioning

confidence: 99%

“…The two routes available to synthesize MRI-inactive nanocrystals with an MRI-active coating are: A) synthesis of a nanocrystal core by a known method, followed by substitution of the coating with an MRI-active one(46) or B) synthesizing the nanocrystal in the presence of MRI active coating materials resulting in the product in one step (Figure 2A/B). (44) The use of either route may depend on the stability of the coating material to the reaction conditions – nanocrystal syntheses often require high temperatures or strongly reducing conditions.…”

Section: Aqueous Phase Synthesis Of Mri-inactive Nanocrystals Coatementioning

confidence: 99%

“…(12) Therefore aqueous phase synthesis may go through an intermediate step, where the nanocrystal is synthesized using an established methodology and the biocompatible coating is subsequently applied via ligand substitution. (46) However, in many cases, the most precise and controllable methods for synthesizing nanocrystals result in structures that are not water soluble, let alone biocompatible, hence there is a need to develop procedures to alter their coating and thereby make them suitable for use in biological systems. (47) The two main strategies adopted are to either perform ligand substitution(47) or to apply an additional, amphiphilic coating.…”

Section: Introductionmentioning

confidence: 99%

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Inorganic nanocrystals as contrast agents in MRI: synthesis, coating and introduction of multifunctionality

et al. 2013

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Inorganic nanocrystals have myriad applications in medicine, which includes their use as drug or gene delivery complexes, therapeutic hyperthermia agents, in diagnostic systems and as contrast agents in a wide range of medical imaging techniques. For MRI, nanocrystals can produce contrast themselves, of which iron oxides have been most extensively explored, or be given a coating that generates MR contrast, for example gold nanoparticles coated with gadolinium chelates. These MR-active nanocrystals can be used in imaging of the vasculature, liver and other organs, as well as molecular imaging, cell tracking and theranostics. Due to these exciting applications, synthesizing and rendering these nanocrystals water-soluble and biocompatible is therefore highly desirable. We will discuss aqueous phase and organic phase methods for synthesizing inorganic nanocrystals such as gold, iron oxides and quantum dots. The pros and cons of the various methods will be highlighted. We explore various methods for making nanocrystals biocompatible, i.e. directly synthesizing nanocrystals coated with biocompatible coatings, ligand substitution, amphiphile coating and embedding in carrier matrices that can be made biocompatible. Various examples will be highlighted and their applications explained. These examples signify that synthesizing biocompatible nanocrystals with controlled properties has been achieved by numerous research groups and can be applied for a wide range of applications. Therefore we expect to see reports of preclinical applications of ever more complex MRI-active nanoparticles and their wider exploitation, as well as in novel clinical settings.

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Section: Nanocrystal Synthesismentioning

confidence: 99%

Section: Aqueous Phase Synthesis Of Mri-inactive Nanocrystals Coatementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inorganic nanocrystals as contrast agents in MRI: synthesis, coating and introduction of multifunctionality

et al. 2013

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“…However, amplification strategies are needed to overcome the inherently low sensitivity of MRI. [2][3][4] One of conventional strategies uses gadolinium (Gd) (III) chelates 5,6 but has been shown to have potential toxicity including nephrogenic systemic fibrosis. 7 In this regard, it is thus crucial to develop efficient nanoparticles (NPs) lacking or having minimal toxicity in vitro and in vivo, including absorption, distribution, metabolism, excretion, and immunotoxiciy.…”

Section: Introductionmentioning

confidence: 99%

Toxicity evaluation of Gd2O3@SiO2 nanoparticles prepared by laser ablation in liquid as MRI contrast agents in vivo

Tian¹,

Yang²,

Yang³

et al. 2014

IJN

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Poor toxicity characterization is one obstacle to the clinical deployment of Gd 2 O 3 @ SiO 2 core-shell nanoparticles (Gd-NPs) for use as magnetic resonance (MR) imaging contrast agents. To date, there is no systematic toxicity data available for Gd-NPs prepared by laser ablation in liquid. In this article, we systematically studied the Gd-NPs’ cytotoxicity, apoptosis in vitro, immunotoxicity, blood circulation half-life, biodistribution and excretion in vivo, as well as pharmacodynamics. The results show the toxicity, and in vivo MR data show that these NPs are a good contrast agent for preclinical applications. No significant differences were found in cell viability, apoptosis , and immunotoxicity between our Gd-NPs and Gd in a DTPA (diethylenetriaminepentaacetic acid) chelator. Biodistribution data reveal a greater accumulation of the Gd-NPs in the liver, spleen, lung, and tumor than in the kidney, heart, and brain. Approximately 50% of the Gd is excreted via the hepatobiliary system within 4 weeks. Furthermore, dynamic contrast-enhanced T1-weighted MR images of xenografted murine tumors were obtained after intravenous administration of the Gd-NPs. Collectively, the single step preparation of Gd-NPs by laser ablation in liquid produces particles with satisfactory cytotoxicity, minimal immunotoxicity, and efficient MR contrast. This may lead to their utility as molecular imaging contrast agents in MR imaging for cancer diagnosis.

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“…[200][201][202] Hybrid NPs, incorporating several components into a single nanostructure system, integrate the strengths of individual components. The hybrid NPs are usually constructed by combining the components of various NPs or by modifying the singlecomponent NPs with some other materials, which is an ideal multimodal contrast agent.…”

Section: Multimodal Imagingmentioning

confidence: 99%

Multifunctional Magnetoplasmonic Nanomaterials and Their Biomedical Applications

Zhou¹,

Zou²,

Koh³

et al. 2014

j biomed nanotechnol

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Multifunctional magnetoplasmonic (Au-Fe x O y ) nanomaterials are characterized by some features of iron oxide and gold, such as surface chemistry, special optical properties, and superparamagnetic properties, which have helped to draw much attention to their biomedical applications. In this review, the state of the art of this rapidly developing field is described. We review the developments in different approaches to integrating the magnetic and plasmonic properties in a single nanoparticle with different morphological traits. Specific plasmonic and magneto-optical properties of magnetoplasmonic nanoparticles are explained; this information should shed light on the future development of multifunctional magnetoplasmonic nanomaterials. We also review cytotoxicity of magnetoplasmonic nanoparticles by in vitro and in vivo studies. With the multifunctional properties of magnetoplasmonic nanomaterials, a variety of applications such as biosensor, bioseparation, multimodal imaging, and therapeutics is possible and is highlighted here, in addition to outlining the future trends and perspectives of these sophisticated nanocomposites.

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Gold nanoparticles coated with gadolinium-DTPA-bisamide conjugate of penicillamine (Au@GdL) as a T1-weighted blood pool contrast agent

Cited by 33 publications

References 45 publications

Inorganic nanocrystals as contrast agents in MRI: synthesis, coating and introduction of multifunctionality

Inorganic nanocrystals as contrast agents in MRI: synthesis, coating and introduction of multifunctionality

Toxicity evaluation of Gd2O3@SiO2 nanoparticles prepared by laser ablation in liquid as MRI contrast agents in vivo

Multifunctional Magnetoplasmonic Nanomaterials and Their Biomedical Applications

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