Gold nanoparticles and vaccine development

Salazar-González, Jorge A.; González‐Ortega, Omar; Rosales‐Mendoza, Sergio

doi:10.1586/14760584.2015.1064772

Cited by 71 publications

(47 citation statements)

References 115 publications

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“…A wide range of molecules, including adjuvants and antigens can be conjugated on AuNPs at high density, resulting in improved immunogenicity and antigen presentation (157,158). AuNPs can be formulated for intranasal administration and can diffuse into the lymph nodes, triggering robust antigenspecific cytotoxic T-cell immune responses (159,160). Tao and coworkers have demonstrated that the peptide consensus M2e of influenza A viruses with a non-native cysteine residue at the C-terminal end could be attached on the AuNPs via thiolate-Au chemistry.…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Nanoparticle-Based Vaccines Against Respiratory Viruses

et al. 2019

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The respiratory mucosa is the primary portal of entry for numerous viruses such as the respiratory syncytial virus, the influenza virus and the parainfluenza virus. These pathogens initially infect the upper respiratory tract and then reach the lower respiratory tract, leading to diseases. Vaccination is an affordable way to control the pathogenicity of viruses and constitutes the strategy of choice to fight against infections, including those leading to pulmonary diseases. Conventional vaccines based on live-attenuated pathogens present a risk of reversion to pathogenic virulence while inactivated pathogen vaccines often lead to a weak immune response. Subunit vaccines were developed to overcome these issues. However, these vaccines may suffer from a limited immunogenicity and, in most cases, the protection induced is only partial. A new generation of vaccines based on nanoparticles has shown great potential to address most of the limitations of conventional and subunit vaccines. This is due to recent advances in chemical and biological engineering, which allow the design of nanoparticles with a precise control over the size, shape, functionality and surface properties, leading to enhanced antigen presentation and strong immunogenicity. This short review provides an overview of the advantages associated with the use of nanoparticles as vaccine delivery platforms to immunize against respiratory viruses and highlights relevant examples demonstrating their potential as safe, effective and affordable vaccines.

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Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Nanoparticle-Based Vaccines Against Respiratory Viruses

et al. 2019

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“…An antigen, once adsorbed or encapsulated by nanoparticles, may be used as an adjuvant for optimization of the immune response aer vaccination. [97][98][99][100][101][102] In 1986, Japanese researchers 103 rst reported success in generating antibodies against glutamate by using colloidal gold particles as a carrier. Subsequently, a number of papers were published whose authors applied and further developed this technique to obtain antibodies to the following haptens and complete antigens: amino acids; 104 142 In all these studies, the haptens or complete antigens were directly conjugated to colloidal gold particles, mixed with complete Freund's adjuvant or alum, and used for animal immunization.…”

Section: Production Of Antibodies By Using Gold Nanoparticlesmentioning

confidence: 99%

Immunological Properties of Gold Nanoparticles

Дыкман¹,

Khlebtsov²

2017

Gold Nanoparticles in Biomedical Applications

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In the past decade, gold nanoparticles have attracted strong interest from the nanobiotechnological community owing to the significant progress made in robust and easy-to-make synthesis technologies, in surface functionalization, and in promising biomedical applications. These include bioimaging, gene diagnostics, analytical sensing, photothermal treatment of tumors, and targeted delivery of various biomolecular and chemical cargos. For the last-named application, gold nanoparticles should be properly fabricated to deliver the cargo into the targeted cells through effective endocytosis. In this review, we discuss recent progress in understanding the selective penetration of gold nanoparticles into immune cells. The interaction of gold nanoparticles with immune cell receptors is discussed. As distinct from other published reviews, we present a summary of the immunological properties of gold nanoparticles. This review also summarizes what is known about the application of gold nanoparticles as an antigen carrier and adjuvant in immunization for the preparation of antibodies in vivo. For each of the above topics, the basic principles, recent advances, and current challenges are discussed. Thus, this review presents a detailed analysis of data on interaction of gold nanoparticles with immune cells.Emphasis is placed on the systematization of data over production of antibodies by using gold nanoparticles and adjuvant properties of gold nanoparticles. Specifically, we start our discussion with current data on interaction of various gold nanoparticles with immune cells. The next section describes existing technologies to improve production of antibodies in vivo by using gold nanoparticles conjugated with specific ligands. Finally, we describe what is known about adjuvant properties of bare gold or functionalized nanoparticles. In the Conclusion section, we present a short summary of reported data and some challenges and perspectives.

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“…18 Antigen-AuNP conjugates, as alternative display vectors to produce highly effective and safe vaccines, show advanced perspectives of greater synthetic control and higher density than on current vector materials such as proteins, peptides/lipopeptides and dendrimers. 19,20 Besides, these materials other than gold may cause immune responses and produce undesired antibodies which decreases the efficiency of vaccinations. 21,22 Owing to the straightforward surface functionalization and excellent biocompatibility, AuNPs do not cause undesired immune response (AuNPs do not elicit the production of antibodies).…”

Section: Introductionmentioning

confidence: 99%