Gold nanoparticles and gold nanoparticle-conjugates for delivery of therapeutic molecules. Progress and challenges

Fratoddi, Ilaria; Venditti, Iole; Cametti, C.; Russo, Maria Vittoria

doi:10.1039/c4tb00383g

Cited by 102 publications

(65 citation statements)

References 156 publications

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“…The synthesis, characterization, and functionalization of differently shaped AuNPs have been extensively reviewed by Dreaden et al [43] and by us [44]. A number of facets of these techniques have been presented and discussed over the past years in a series of papers from our group [45][46][47][48][49][50][51][52][53][54][55][56].…”

Section: Gold Nanospheresmentioning

confidence: 98%

How toxic are gold nanoparticles? The state-of-the-art

et al. 2015

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With the growing interest in the applications of gold nanoparticles in biotechnology and their physiological effects, possible toxicity of gold nanoparticles is becoming an increasingly important issue. A large number of studies carried out over the past few years under a variety of experimental conditions and following different protocols have produced conflicting results, leading to divergent views about the actual safety of gold nanoparticles in human applications.This work is intended to provide an overview of the most recent experimental results and thereby summarize current state-of-the-art. Rather than presenting a comprehensive review of the available literature in this field, which would be impractically broad, we have selected representative examples of both in vivo and in vitro studies, which clearly demonstrate the need for urgent and rigorous standardization of experimental protocols. Despite their significant potential, the safety of gold nanoparticles is highly controversial at this time, and important concerns have been raised that need to be properly addressed. Factors such as shape, size, surface charge, coating, and surface functionalization are expected to influence the interactions of particles with biological systems to a different extent, resulting in different outcomes and influencing the potential of gold nanoparticles for biomedical applications.Moreover, despite continuous attempts to establish a correlation between structure of the particles and their interactions with biological systems, we are still far from elucidating the toxicological profile of gold nanoparticles in an indisputable manner. This review is intended to contribute towards this goal, offering a number of suggestions on how to achieve the systematization of data on the most relevant physico-chemical parameters, which govern and control the toxicity of gold nanoparticles at cellular and whole-organism levels.

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Section: Gold Nanospheresmentioning

confidence: 98%

How toxic are gold nanoparticles? The state-of-the-art

et al. 2015

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“…Noble metal nanoparticles and, in particular, gold nanoparticles [AuNPs] have elicited a lot of interest, due to their size and shape dependent unique optoelectronic properties [2,3,4] and, more recently, for biomedical applications and therapeutics [5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Bioconjugation of gold-polymer core–shell nanoparticles with bovine serum amine oxidase for biomedical applications

Venditti

Hassanein

Fratoddi

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…For this purpose, the development of a proper model of GNPs was mandatory in order to investigate the GNPs fate during the uptake process. Currently, GNPs synthesis is a growing research theme [2, 25, 26]. A recent work reports on the synthesis of GNPs capped with 3mercapto-1-propansulfonate and 1-thioglucose, which show enhanced cell internalization, short term cytotoxicity and long term cell killing, when tested “in vitro” for HSG cells [16].…”

Section: Resultsmentioning

confidence: 99%

Fluctuation Spectroscopy Analysis of Glucose Capped Gold Nanoparticles

Porcaro

Miao²,

Kota³

et al. 2016

Langmuir

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In this work, we report the synthesis and biophysical studies carried out on a new kind of biocompatible and very stable gold nanoparticles (GNPs) stabilized with Glucose through a PEG linker (AuNP-PEG-Glu). The synthetic path was optimized to obtain nanoparticles of controlled sizes. Z-Potential and Dynamic Light Scattering measurements allowed assessing the nanodimension, dispersity, surface charge and stability of our GNPs. Confocal Microscopy demonstrated qualitatively that Glucose molecules are successfully bonded to GNPs surface. For our study, we selected nanoparticles with diameter in a range that maximizes the internalization efficiency in cells (40 nm). A detailed investigation about the biophysical proprieties of AuNP-PEG-Glu was carried out by means of Fluorescence Correlation Spectroscopy (FCS) and Orbital Tracking techniques. This work gives new insights about the uptake mechanism of Gold nanoparticles capped with glucose molecules.

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Gold nanoparticles and gold nanoparticle-conjugates for delivery of therapeutic molecules. Progress and challenges

Cited by 102 publications

References 156 publications

How toxic are gold nanoparticles? The state-of-the-art

How toxic are gold nanoparticles? The state-of-the-art

Bioconjugation of gold-polymer core–shell nanoparticles with bovine serum amine oxidase for biomedical applications

Fluctuation Spectroscopy Analysis of Glucose Capped Gold Nanoparticles

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