Gold nanoparticle/ZnO nanorod hybrids for enhanced reactive oxygen species generation and photodynamic therapy

Kang, Zhuo; Yan, Xiaoqin; Zhao, Li; Liao, Qingliang; Zhao, Kun; Du, Hongwu; Zhang, Mengjie; Zhang, Xueji; Zhang, Yue

doi:10.1007/s12274-015-0712-3

Cited by 87 publications

(54 citation statements)

References 54 publications

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“…Green ZnO NPs synthesized from the plant extracts containing no harmful surfactant and harsh solvent residuals are particularly useful for PDT treatment. (Figure 31a) [167]. In comparison to pure ZnO NR, the amount of photoexcited electrons increased markedly on AuNPs-doped ZnO NR, leading to the generation of high ROS yield (Figure 31b).…”

Section: Photocatalytic Toxicitymentioning

confidence: 95%

“…In this respect, ZnO:AuNPs hybrids show a great potential for cancer treatment in PDT due to the creation of ROS under visible light (Figure 7a). (Figure 31a) [167]. In comparison to pure ZnO NR, the amount of photoexcited electrons increased markedly on AuNPs-doped ZnO NR, leading to the generation of high ROS yield (Figure 31b).…”

Section: Photocatalytic Toxicitymentioning

confidence: 95%

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Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity

Liao

Jin

et al. 2020

IJMS

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This article presents a state-of-the-art review and analysis of literature studies on the morphological structure, fabrication, cytotoxicity, and photocatalytic toxicity of zinc oxide nanostructures (nZnO) of mammalian cells. nZnO with different morphologies, e.g., quantum dots, nanoparticles, nanorods, and nanotetrapods are toxic to a wide variety of mammalian cell lines due to in vitro cell–material interactions. Several mechanisms responsible for in vitro cytotoxicity have been proposed. These include the penetration of nZnO into the cytoplasm, generating reactive oxygen species (ROS) that degrade mitochondrial function, induce endoplasmic reticulum stress, and damage deoxyribonucleic acid (DNA), lipid, and protein molecules. Otherwise, nZnO dissolve extracellularly into zinc ions and the subsequent diffusion of ions into the cytoplasm can create ROS. Furthermore, internalization of nZnO and localization in acidic lysosomes result in their dissolution into zinc ions, producing ROS too in cytoplasm. These ROS-mediated responses induce caspase-dependent apoptosis via the activation of B-cell lymphoma 2 (Bcl2), Bcl2-associated X protein (Bax), CCAAT/enhancer-binding protein homologous protein (chop), and phosphoprotein p53 gene expressions. In vivo studies on a mouse model reveal the adverse impacts of nZnO on internal organs through different administration routes. The administration of ZnO nanoparticles into mice via intraperitoneal instillation and intravenous injection facilitates their accumulation in target organs, such as the liver, spleen, and lung. ZnO is a semiconductor with a large bandgap showing photocatalytic behavior under ultraviolet (UV) light irradiation. As such, photogenerated electron–hole pairs react with adsorbed oxygen and water molecules to produce ROS. So, the ROS-mediated selective killing for human tumor cells is beneficial for cancer treatment in photodynamic therapy. The photoinduced effects of noble metal doped nZnO for creating ROS under UV and visible light for killing cancer cells are also addressed.

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Section: Photocatalytic Toxicitymentioning

confidence: 95%

Section: Photocatalytic Toxicitymentioning

confidence: 95%

Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity

Liao

Jin

et al. 2020

IJMS

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“…Only 40% of E. coli cells remained alive after the treatment with Te-Au 0.2 NW-based carbon fiber fabrics for 10 min, and around 20% were alive after the treatment for 30 min. This is because the presence of Au NPs on semiconductor NMs would help to generate ROS [ 13 , 16 , 25 , 26 ]. The antibacterial activity of the as-prepared carbon fiber fabrics continued to increase as more Au content deposited on the Te NWs.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Te and Te-Au Nanowires-Based Carbon Fiber Fabrics for Antibacterial Applications

Chou

Tsao

et al. 2016

IJERPH

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Pathogenic bacteria that give rise to diseases every year remain a major health concern. In recent years, tellurium-based nanomaterials have been approved as new and efficient antibacterial agents. In this paper, we developed the approach to directly grow tellurium nanowires (Te NWs) onto commercial carbon fiber fabrics and demonstrated their antibacterial activity. Those Te NWs can serve as templates and reducing agents for gold nanoparticles (Au NPs) to deposit. Three different Te-Au NWs with varied concentration of Au NPs were synthesized and showed superior antibacterial activity and biocompability. These results indicate that the as-prepared carbon fiber fabrics with Te and Te-Au NWs can become antimicrobial clothing products in the near future.

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“…有机金属光敏剂有更长的三线态寿命, 能增加其与氧物种的反应以及ROS的生成 [67] , 如玫瑰红(RB)在银岛膜(silver island films, SiFs)存在的条件下, 比单纯的玫瑰红增加了3倍的单线态氧产率. 随后一系列的研究使用Ag, Au, Zn和Ni纳米粒子也得到了增高的单线态氧产率 [68,69] Au纳米粒与ZnO纳米棒组成的混合金属光敏剂, 当 ZnO:Au的摩尔比为20 : 1时 , 单线态氧产率最佳, 此时ZnO和Au有最大的表面接触面积 [70] . 钌复合物 Ru(II)(N3)具有多种三线态, 金属与配体或配体与配体之间存在多种电子转移, 目前有多种含有金属钌的光敏剂处于研究之中 [71~75] .…”

Section: 金属纳米簇、金属纳米结晶或金属纳米颗粒能增unclassified

Reactive oxygen species in photodynamic therapy

Jiang¹,

Dai²

2018

Chin. Sci. Bull.

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Gold nanoparticle/ZnO nanorod hybrids for enhanced reactive oxygen species generation and photodynamic therapy

Cited by 87 publications

References 54 publications

Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity

Interactions of Zinc Oxide Nanostructures with Mammalian Cells: Cytotoxicity and Photocatalytic Toxicity

Fabrication of Te and Te-Au Nanowires-Based Carbon Fiber Fabrics for Antibacterial Applications

Reactive oxygen species in photodynamic therapy

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