Gold nanoparticle should understand protein corona for being a clinical nanomaterial

Charbgoo, Fahimeh; Nejabat, Mojgan; Abnous, Khalil; Soltani, Fatemeh; Taghdisi, Seyed Mohammad; Alibolandi, Mona; Shier, W. Thomas; Steele, Terry W. J.; Ramezani, Mohammad

doi:10.1016/j.jconrel.2018.01.002

Cited by 117 publications

(91 citation statements)

References 126 publications

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“…Adsorbed proteins confer a different biological identity to NPs, which may completely alter the subsequent cellular responses. 50 Biomolecules can be bound through irreversible interactions, forming the so-called hard corona, or through weak interactions, yielding a soft corona. The NPs-protein complex is a complicated and dynamic entity, and its composition may change with time and environmental alterations, through continuous protein association and dissociation.…”

Section: Protein Corona Modulationmentioning

confidence: 99%

Cellular Uptake of Nanoparticles versus Small Molecules: A Matter of Size

2018

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The primary function of the cell membrane is to protect cells from their surroundings. This entails a strict regulation on controlling the exchange of matter between the cell and its environment. A key factor when considering potential biological applications of a particular chemical structure has to do with its ability to internalize into cells. Molecules that can readily cross cell membranes are frequently needed in biological research and medicine, since most therapeutic entities are designed to modulate intracellular components. However, the design of molecules that do not penetrate cells is also relevant toward, for example, extracellular contrast agents, which are most widely used in clinical diagnosis. Small molecules have occupied the forefront of biomedical research until recently, but the past few decades have seen an increasing use of larger chemical structures, such as proteins or nanoparticles, leading to unprecedented and often unexpectedly novel research. Great achievements have been made toward understanding the rules that govern cellular uptake, which show that cell internalization of molecules is largely affected by their size. For example, macromolecules such as proteins and nucleic acids are usually unable to internalize cells. Intriguingly, in the case of nanoparticles, larger sizes seem to facilitate internalization via endocytic pathways, through which the particles remain trapped in lysosomes and endosomes. In this Account, we aimed at presenting our personal view of how different chemical structures behave in terms of cell internalization due to their size, ranging from small drugs to large nanoparticles. We first introduce the properties of cell membranes and the main mechanisms involved in cellular uptake. We then discuss the cellular internalization of molecules, distinguishing between those with molecular weights below 1 kDa and biological macromolecules such as proteins and nucleic acids. In the last section, we review the biological behavior of nanoparticles, with a special emphasis on plasmonic nanoparticles, which feature a high potential in the biomedical field. For each group of chemical structures, we discuss the parameters affecting their cellular internalization but also strategies that can be applied to achieve the desired intracellular delivery. Particular attention is paid to approaches that allow conditional regulation of the cell internalization process using external triggers, such as activable cell penetrating peptides, due to the impact that these systems may have in drug delivery and sensing applications. The Account ends with a "Conclusions and Outlook" section, where general lessons and future directions toward further advancements are briefly presented.

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Section: Protein Corona Modulationmentioning

confidence: 99%

Cellular Uptake of Nanoparticles versus Small Molecules: A Matter of Size

2018

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“…[70] For instance, gold nanoparticles (AuNPs) can interact with serum proteins through multiple interactions, such as Van der Waals forces, hydrophobic effects, electrostatic interactions, hydrogen bonds, and sulfide bands. [71] In order to minimize the side effects of the uncontrollable formation of the protein corona in blood, self-assembly of proteins and nanoparticles in solutions has been investigated as a strategy to construct nanodrugs with improved therapeutic efficiencies. Nanoparticle-induced self-assembly of proteins is versatile for the formation of various nanostructures, including nanoparticles with an inorganic core and a protein shell, protein nanoparticles with embedded inorganic nanoparticles, and protein fibrils.…”

Section: Nanoparticle-induced Self-assembly Of Proteinsmentioning

confidence: 99%

Self‐Assembling Proteins for Design of Anticancer Nanodrugs

Zou

Chang

Yan

2020

Chemistry An Asian Journal

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Inspired by the diverse protein-based structures and materials in organisms, proteins have been expected as promising biological components for constructing nanomaterials toward various applications. In numerous studies protein-based nanomaterials have been constructed with the merits of abundant bioactivity and good biocompatibility. However, self-assembly of proteins as a dominant approach in constructing anticancer nanodrugs has not been reviewed.Here, we provide a comprehensive account of the role of protein self-assembly in fabrication, regulation, and application of anticancer nanodrugs. The supramolecular strategies, building blocks, and molecular interactions of protein selfassembly as well as the properties, functions, and applica-tions of the resulting nanodrugs are discussed. The applications in chemotherapy, radiotherapy, photodynamic therapy, photothermal therapy, gene therapy, and combination therapy are included. Especially, manipulation of molecular interactions for realizing cancer-specific response and cancer theranostics are emphasized. By expounding the impact of molecular interactions on therapeutic activity, rational design of highly efficient protein-based nanodrugs for precision anticancer therapy can be envisioned. Also, the challenges and perspectives in constructing nanodrugs based on protein self-assembly are presented to advance clinical translation of protein-based nanodrugs and next-generation nanomedicine. 2 3 4 5 6 7 8

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“…[ 15 ] Therefore, numerous studies have been performed to determine the nature of the PC and its roles in changing the biological effects of PC‐decorated GNPs in vitro and in vivo. [ 6,16 ] In most studies, the production of PC is not conducive to the in vivo application of NPs, such as leading to an increase in particle size, a higher clearance of the reticuloendothelial system, and a decrease in cellular uptake. However, there are still some clues that the performance of GNP can be improved by rewriting the original surface chemistry of GNPs using the PC.…”

Section: Introductionmentioning

confidence: 99%

Biological Behavior Regulation of Gold Nanoparticles via the Protein Corona

Hong

Ding

2020

Adv Healthcare Materials

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One of the difficulties in the translation of gold nanoparticles (GNPs) into clinical practice is the formation of the protein corona (PC) that causes the discrepancy between the in vitro and in vivo performance of GNPs. The PC formed on the surface of GNPs gives them a biological identity instead of an initial synthetic one. In most instances, this biological identity increases the particle size, leads to more clearance by the reticuloendothelial system, and causes less uptake by target cells. However, the performance of GNPs can still be improved by rewriting their original surface chemistry via the PC. This review specifically focuses on discussing the main influence factors, including the biological environment and physicochemical properties of GNPs, which affect the production and status of the PC. The status of the PC such as the amount, thickness, and composition subsequently influence the biological behavior of GNPs, especially their cellular uptake, cytotoxicity, biodistribution, and tumor targeting. Further understanding and revealing the impacts of the PC on the biological behavior of GNPs can be a promising and important strategy to regulate and improve the performance of GNP‐based biosystems in the future.

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Gold nanoparticle should understand protein corona for being a clinical nanomaterial

Cited by 117 publications

References 126 publications

Cellular Uptake of Nanoparticles versus Small Molecules: A Matter of Size

Cellular Uptake of Nanoparticles versus Small Molecules: A Matter of Size

Self‐Assembling Proteins for Design of Anticancer Nanodrugs

Biological Behavior Regulation of Gold Nanoparticles via the Protein Corona

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